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Trauma and Stress
A. Psychological Stress and Psychopathology
When something unexpected and out of our control occurs to us, we suffer
psychological stress. It might be a fire that starts in the building we're in. We might be the
target of another armed robbery. Even trying to help someone but ending up in an
unexpected circumstance might cause stress. Individuals carrying out their duties as a
hurricane approached while still dealing with the horrors of war and making crucial
decisions. Sometimes these encounters result in intense emotional reactions, and other
times they cause psychological disorders like post-traumatic stress disorder (PTSD).
Also, as we learned in the chapter on depression, the onset of depression is frequently
associated with a psychologically stressful life event.
It is difficult to comprehend how stress and trauma link to health and
psychopathology. The functions that these elements play in psychopathology are starting
to be established through research. Stress and trauma are clearly related to some illnesses.
By definition, PTSD is unquestionably the outcome of stressful events. Conversely,
people with depression are 2.5 to 10 times more likely than non-depressive people to
have just gone through a severe, negative, stressful incident. Furthermore, melancholy,
alcohol misuse, and criminal behavior are linked to significant stress and trauma from
childhood abuse and neglect. Stress can make the symptoms of diseases like
schizophrenia and bipolar disorder worse.
In general, difficulties with mental and physical health later in life are linked to
early stress. Stressful events alter both psychological and physiological responses to
subsequent stressful events, which can lead to changes in both physical and mental
health. These alterations may be influenced by psychological variables, brain changes
brought on by brain growth, genetic and epigenetic changes, endocrine changes, and
social and economic influences, among others.
B. The Physiological Mechanisms Related to Stress and Trauma
Stress and trauma cause a number of physiological reactions in us. They include
the endocrine system, which includes the hypothalamic—pituitary—adrenal (HPA) axis,
the autonomic nervous system (ANS), and modifications to cortical processes. Chemical
tagging of the immune system's response is also among them. In a variety of feedback
loops, stress pathways engage multiple brain regions and other functions. Both conscious
and preconscious pathways send a signal to the amygdala when there is a perceived
threat. The ANS is stimulated as a result of the production of corticotrophin-releasing
hormone (CRH). In addition to producing glucocorticoids via a separate mechanism, the
adrenal glands also create epinephrine. The fight-or-flight reaction is triggered by this.
The locus coeruleus releases norepinephrine under persistent stress, and this
norepinephrine travels to the amygdala and causes the production of additional CRH.
One of the simplest theories to understand is the evolutionary logic of survival.
An organism risks harm or death if it is unable to effectively respond to a threat. Its genes
cannot be passed on if it is dead. If it gets harmed, it can become less desirable as a mate
or lose the ability to do so. Thus it stands to reason that advanced survival mechanisms
will have been developed by organisms. The ANS, a network of hypothalamic, pituitary,
and adrenal responses, the circulatory system, metabolism, and the immune system are
some of the fundamental systems. As these processes are so susceptible to environmental
alterations, recurring stressful situations can alter how they operate.
These pathways' primary purpose is to get the body ready for action. You'll need
fuel to run if you notice a bear. Actually, a bear is not required. The physiological
systems used to protect you from almost all stimuli are similar. These channels transport
physiological energy supplies to the required muscles and organs. They bring about a
general transition from energy storage to energy use. This is comparable to stepping on
your car's gas pedal quickly to escape a hazardous scenario. Temporarily, the body's
priorities shift from flexibility, which includes past and future considerations, to
concentration on the present situation. Your body no longer saves energy, thinks about
sex, or has your immune system fret about chronic illness. Threat-relevant cues and
memories become crucial as they apply to the current situation both cognitively and
emotionally. As you are aware, your brain has a significant impact on how stressful an
experience is, whether it be taking a test or reacting to a loud noise. The brain affects
peripheral physiology through two main mechanisms.
The adrenal medulla is one of the many organs that the autonomic nervous system
innervates. This release of catecholamines (norepinephrine and epinephrine) from the
sympathetic nerve terminals is the first pathway. Because norepinephrine and epinephrine
have a rapid onset of action, you can react immediately. It should be emphasized that
these molecules are referred recognized as neurotransmitters if they are released at the
synapse. They are referred to as hormones if they are released into the bloodstream. The
release of catecholamines occurs as a result of the autonomic nervous system (ANS)
innervating the adrenal medulla in reaction to stress. The HPA axis and sympathetic
system function substantially in concert throughout the body, mobilizing energy and
maintaining blood pressure under stress.
Cells from the hypothalamus are released into the bloodstream and travel to the
pituitary gland in the second pathway. As a result, the pituitary releases hormones that
affect other hormones, which in turn affect immune system cells and peripheral organs
like the adrenals. Glucocorticoids are the name given to these hormones. Simply put, this
mechanism aids in transforming the body's reserves of fats and carbs into readily usable
energy. It was critical that the immune system be active in order to defend the organism
from injuries because historically, the survival mechanisms that would have triggered this
system would have required conflict and fighting. The hypothalamic-pituitary-adrenal
(HPA) axis is the name of this defensive system. These mechanisms have been
researched in psychology and physiology under the heading of psychological stress.
Furthermore, schizophrenia, autism, and depression are only a few of the
psychopathologies where the HPA axis is either underactive or overactive. Hypothalamic
cells are released into the bloodstream and travel to the pituitary gland as part of another
stress pathway. As a result, the pituitary releases glucocorticoids, a class of hormones that
affect other hormones. This mechanism aids in transforming carbohydrate and fat
reserves into instantly usable energy sources.
Corticotrophin-releasing hormone (CRH) (also known as corticotrophin-releasing
factor [CRF]) is a chemical that is produced by the hypothalamus in the brain, and it
stimulates the pituitary to release a hormone called adrenocorticotropic hormone
(ACTH). The production of glucocorticoids by the adrenal glands is triggered by the
presence of ACTH in the blood, which raises blood sugar levels and, as a result, the
amount of energy available to our bodies under stress. The amygdala and hippocampus
have inhibitory and excitatory control over HPA, respectively. The adrenal cortex
releases cortisol after receiving the CRF that was released by the hippocampus.
In 1932, Walter Cannon first referred to the stress response as the body's reaction
to danger. Despite the fact that Cannon first focused on animals, research since his time
has revealed that the fundamental stress reaction also applies to people. The fight-or-
flight response is the name given to the general stress response. The amygdala and other
cortical systems contribute to the stress response, which is carried out by a number of
interrelated systems. As a result, the hypothalamus activates the sympathetic nervous
system and the HPA axis. In general, stress weakens our capacity for planning and
thinking while enhancing our emotional reactions. The HPA axis has been associated
with psychopathology, including depression, anxiety, and the onset of psychosis in
adolescence.
The autonomic nerve system (ANS) has three distinct functions. Upholding
homeostatic conditions within the body is the first task. This maintains equilibrium in the
processing of internal processes including heart rate and blood pressure. The second task,
which will be stressed in this chapter, is to coordinate the body's reaction to stress and
exercise. Assisting with the endocrine system's control of reproduction is the third task.
The sympathetic division and the parasympathetic division are frequently used to
describe the autonomic nervous system (ANS). Through the spinal cord's middle section,
the sympathetic division communicates with its target organs. The fight-or-flight
response is caused by the sympathetic division. For the body to be energized, this
emergency response generates resources. Because they cause the body to react with
adrenaline, stimulating it, these connections are adrenergic. The organ that the
sympathetic nervous system innervates generally experiences a constant effect. Having a
sympathetic tone is what this is. Internal organs are affected in a complementary manner
by the sympathetic and parasympathetic branches of the autonomic nervous system
(ANS).
On the other side, the parasympathetic nervous system is engaged in the
replenishment of bodily reserves and the removal of bodily waste. The spinal cord's top
and lower ends serve as its points of connection. As a result, acetylcholine and
cholinergic linkages are present. These responses typically involve a decrease in activity
and a process of returning the body to homeostasis. Whilst the sympathetic and
parasympathetic systems are frequently perceived as operating in opposition to one
another, their real interaction is far more nuanced.
To aid organisms in defending against infections, the immune system has
evolved. These defense systems that aid in immunological function seem to be some of
the oldest to have developed. Sneezing, coughing, and crying are common reactions that
act as additional barriers to keep infections from entering the body. Several levels of
immune activity are present in the body to deal with pathogens if they do enter.
Identification of foreign and native cells is a crucial function of the immune system. The
immune system recognizes foreign substances such as bacteria, viruses, and parasites that
enter our bodies.
When faced with particular pathogens like viruses or when under stress, the
immune system is activated. The immune system was formerly thought of as a distinct
system that ran on its own. Yet, numerous research conducted since the 1970s have
shown that the brain and immune system are interconnected. It has been demonstrated, in
example, that psychological stress can affect the immune system in a way that increases
the likelihood of an organism contracting an illness. It was also demonstrated by Robert
Ader in 2007 that the immune system may be classically trained. These kinds of research
contributed to the development of the discipline of psychoneuroimmunology.
The study of how psychological variables might affect the immune system is
known as psychoneuroimmunology. Loneliness, a lack of social support, depression,
marital problems, bereavement, and natural disasters are a few psychological issues that
might affect the immune system. Close connections and other factors that lower negative
emotions improve immune system performance. It has also become clear that the immune
system can affect the brain and consequently behavior, in addition to influencing how the
immune system responds to experience. It has recently been discovered that immune
system dysfunction might contribute to mental disease. The person withdraws from social
engagements and does not actively seek out new experiences when they are ill or
depressed. Moreover, these people do not react to rewards or pleasant experiences.
C. The Study of Stress
Stress in physics is the term used to describe the strain applied to a substance.
Selye used the phrase to categorize physiological reactions to various difficulties, such as
heat, cold, discomfort, noise, hard effort, and so forth. The body responds similarly too
many of these many stressors, according to one of Selye's early discoveries. The general
adaption syndrome was Selye's term for this reaction (GAS). Three phases were thought
to be involved in the GAS. The alarm stage was the first. This was a first-time stress
response that included an increase in adrenal activity as well as responses from the
sympathetic nervous system, like an accelerated heart rate. The resistance stage was the
next phase. In this phase, the body adjusts to the stress by making more energy resources
and defenses against infection and tissue damage available. Exhaustion was the third
stage, during which body resources were used up. The physiological stress reactions that
the body uses to defend itself and heal itself are paradoxical, as Selye noted.
Due of the term's imprecise definition, understanding stress can be difficult. The
name should be changed to alfostasis, he recommended. The ability of the body to
maintain stability through change is referred to as allostasis. The brain, then, detects
stressful conditions and adjusts. This causes the brain to recognize situations that are
threatening, remember them, and trigger stress responses. Social or physical stress are
both examples of this. Many techniques can be used by brain processes to become stable.
The autonomic nervous system, cortisol, our metabolic system, and our immune system
all engage in a complex set of interactions in our bodies in reaction to stress that work to
try to restore homeostasis.
Hence, allostatic systems are systems built with change adaptation in mind.
Humans typically associate change with stress, which might include risky events,
unpleasant crowds and settings, contracting an infection, and giving a performance in
front of people. According to some experts, stress may even be more severe in humans
than in other animals because we have the cognitive capacity to employ our imagination
to intensify stress. The body must do two jobs as part of the total stress response. The
allostatic response, which starts a complicated adaptive pathway, must first be activated.
The fight-or-flight reaction and the tend-and-befriend response are two examples of this.
The second task—turning off these responses—must be started as soon as the threat has
passed. Many studies indicate that persistent exposure to stress may prevent these two
processes from working properly, which in turn causes a number of physiological issues.
Allostatic load refers to the cumulative damage that the body sustains as a result of
responding to stressful situations.
McEwen (1998) examined allostatic stress in terms of four specific scenarios. The
first scenario illustrates how regular exposure to stressors has the potential to raise
allostatic load. These pressures may be psychological or physical in origin. The absence
of adaptation or habituation to the repeated recurrence of a certain stressor is the second
requirement for a rise in allostatic load. While traveling great distances by car or flying,
for instance, some people nonetheless exhibit significant physiological reactions, despite
the fact that the evidence points to little risk in these instances. The third scenario
illustrates the fact that different people have different reactions to shifting circumstances.
After the original threat has passed, some people in particular exhibit a slower return to a
physiological state that is not challenging. The final and fourth scenario is when a system
overreacts as a result of a system's failure to respond to stress. To put it another way, if
one system doesn't react to stress in a way that is appropriate, then activating another
system would be needed to provide the necessary counter-regulation and restore the
system to homeostasis.
D. Trauma and Stressor-Related Disorders in DSM-5
Adjustment disorders, acute stress disorder, and post-traumatic stress disorder are
the three most severe of these (PTSD). The severity of the stressor is greatest in PTSD
and least severe in adjustment disorder. In reality, only an event that is perceived as
distressing qualifies as an adjustment disorder rather than the experience of a traumatic
event. Initially, an acute stress disorder was thought to be a more immediate response to
stress, which could be of a non-traumatic character.
1. Adjustment Disorders
When things do not turn out as planned, such as when a job is lost, a
relationship ends, or money is lost in a business partnership, everyone reacts.
When a tree falls on your house or your basement floods due to heavy rains,
these natural calamities elicit tremendous emotions within you. Long-lasting
emotional responses may result from things like living in a challenging area or
having a physical impairment. Those instances are distressing. Nonetheless, it
can be termed an adjustment disorder when the responses to such occurrences
are not in line with how serious the event actually was. Performance at work
and in social settings may both be hampered by the response to the
occurrence. The reaction to the stressful event must occur within three months
of its occurrence and must not endure for more than six months in order to
qualify for an adjustment disorder diagnosis.
These diseases are believed to be widespread within the mental health
system, despite the fact that official epidemiological studies on adjustment
disorders are less common than on illnesses like anxiety or depression.
According to estimates by R. Jones, Yates, and colleagues, they comprise up
to 20% of those seeking mental health care and 7.1% of inpatients. The
prevalence of these illnesses is slightly (by about 60% to 40%) higher in
females than in males. Although adjustment disorders are fairly common,
there is limited research on treatments with empirical validity. The treatments
for adjustment problems are typically the same as those for PTSD and anxiety.
Both psychosocial counseling and anxiety drugs fall under this category.
2. Acute Stress Disorder
An immediate response to distressing events, acute stress disorder
lasts for three days to one month. If the clinical symptoms persist after this
time, the condition would be referred to as PTSD. The trauma, like PTSD, can
be caused by incidents like combat, physical assault, muggings, terrorist
attacks, torture, physical and sexual abuse, vehicle accidents, and natural
catastrophes like hurricanes, fires, and earthquakes. Moreover, witnessing
terrible events happen to another individual might result in acute stress
disorder.
Clinical symptoms following the trauma are described in terms of five
categories. The first category is intrusion and can include such symptoms as
involuntary distressing memories, distressing dreams, and flashbacks. The
second category is negative mood and includes the inability to experience
happiness. The third category is dissociative symptoms such as feeling in a
fog or the inability to remember important aspects of the trauma. The fourth
category is avoidance symptoms. These symptoms include avoiding
situations, people, and places that remind one of the trauma. The fifth
category is arousal symptoms. These include sleep disturbance, angry
outbursts, showing extreme vigilance, problems with concentration, and a
sensitivity to events that cause a startle. A given individual may show
symptoms in a limited number or all of these five categories.
3. Posttraumatic Stress Disorder (PTSD)
Studies on long-term health issues caused by combat have been
conducted at least since the American Civil War. What we now refer to as
PTSD appears to have a new label associated with every battle. Shell shock
was a word that was frequently used during World War |. As the name
suggests, it was believed that the shells' explosions led to a psychological and
bodily reaction, which included a sense of helplessness. Other psychiatric
words, such as neuroasthenia, psychoneurosis, and "war exhaustion," were
employed during World War II and the Korean War. Many members of
American society during the Vietnam War attributed the previously
mentioned "battle tiredness" to drug use or a stress reaction.
According to M. Friedman, Keane, and Resick (2014), Shalev,
Liberzon, and Marmar (2017), as well as Vermetten & Lanius (2012), PTSD
is caused by an actual threat that leaves the victim feeling extremely terrified,
powerless, or horrified. These events can also include rape and assault, family
and social violence, forest fires, and accidents in addition to combat (see
Table 7.3). Assaultive violence carries the highest risk for PTSD. PTSD can
also be brought on by accumulative stress. Acute stress disorder is a transient
response to trauma, but PTSD is evident when the response persists for more
than a month.
According to estimates, 60% of men and 50% of women will face a
major threat to their own lives or the life of a loved one at some point in their
lifetime. 8.7% of them will experience PTSD at some point in their lives. In
the US, the 12-month prevalence is 3.5%. (APA, 2013). Women experience
PTSD twice as frequently as males. Moreover, women have PTSD for a
longer time than men. While being present in many different cultures, PTSD
is more common in the United States than it is in Europe, Asia, Africa, and
Latin America. Although New Zealand reports a rate of 6.1%, it is believed to
be under 1% in these cultures (WHO, 2005).
E. DSM-5 Criteria for PTSD
Several traumatic experiences that are followed by negative reactions are among
the DSM-5's diagnostic criteria for PTSD. Initially, the person is exposed to unpleasant
situations that could result in harm or attack. The criteria also takes into account repeated
instances of first responders collecting corpse parts or police looking into child abuse.
The individual also encounters exposure-related intrusions after the exposure, which is
the second factor. These intrusions can take the form of flashbacks in which the person
relives the experience, dream content relating to the incident, upsetting memories of the
event, and discomfort or physiological reactions to reminders of the event.
Third, the person stays away from stimuli related to the traumatic incident. In
addition to internal thoughts or feelings, these stimuli may also involve people, places, or
things connected to the event. Fourth, the person feels alterations in their cognitive
processes, including the difficulty to recall crucial details of the event, negative self-
attributions, blaming others, unpleasant feelings, alienation, loss of interest, and the
inability to feel happy. Fifth, the person exhibits elevated arousal and reactivity, which
includes sleep disruptions, impatience, and focus issues.
F. The Physiological Aspects of Post-Traumatic Stress Disorder
Animal models of stress and trauma have demonstrated that prolonged, severe
stress can harm the establishment of the hippocampus region in the brain. This is likely to
be caused by increased corticosteroids, which are known to harm cells, inhibit neural
regeneration, and decrease dendritic branching. Many studies on humans have been
conducted as a result to look at how the hippocampus functions in PTSD sufferers. Also,
new insights into the cortical networks involved in the formation and dissolution of fear
have identified particular brain areas linked to PTSD. In addition to the default and
salience networks, these include the hippocampus, amygdala, and medial prefrontal
cortex (PFC). Due to its function in the encoding of memories, including emotional ones,
the hippocampus is significant. The amygdala is engaged in the evaluation of threat and
contributes to the conditioning of fear. When doing a task, emotional information is
inhibited by the medial PFC, which includes the ACC. The same parts of the brain are
involved in the processes of anxiety and terror.
The notion that people with PTSD have smaller hippocampus volumes than
people without PTSD is generally supported by ample evidence. The volume of the left
and right hippocampuses in people with PTSD was, on average, 6.9% and 6.6% lower,
respectively. Interesting research suggests that stress inhibits the hippocampus's normal
ability to regenerate new neurons. Together with decreased connection between the ACC
and amygdala, ACC abnormalities have also been observed in PTSD. The amygdala has
not consistently shown signs of shrinkage, despite being a crucial component of the fear
network. It is hypothesized that the amygdala's hyperresponsiveness is connected to the
heightened fear response.
The lack of inhibition from the frontal regions to the amygdala may be the cause
of this. The inability to suppress or squelch fear-related sensations would likewise be
related to this. There is also an emotional counterpart. In other words, persons who have
PTSD exhibit diminished limbic reactions to pleasant facial expressions, which may be
connected to emotional numbing. You'll find that DSM 5 defines emotional numbing as
the incapacity to feel joy or happiness.
G. Treatment for Post-Traumatic Stress Disorder
Examining the cerebral and associative networks involved can help us understand
the physiological changes brought on by trauma. Certain associations may become more
intense or "hot" than others that stay "cool" on an associative level. Repeated exposure to
trauma has been demonstrated to make it more challenging to integrate those experiences
into less sentimental or "cold" autobiographical recollections. Moving the person's hot
trauma associations to a more chilled, or nonreactive, memory process, is one of therapy's
objectives.
Depression, substance addiction, and anxiety disorders like obsessive-compulsive
disorder (OCD), panic disorder, agoraphobia, and social anxiety are all common co-
occurring illnesses with PTSD. For instance, the National Vietnam Veterans
Readjustment Study revealed that 98% of people with combat-related PTSD also had a
co-occurring mental illness in their lives. Also, they mentioned other physical health
issues. This implies that more than one approach is necessary for the treatment of PTSD.
The wide range of PTSD symptoms has led to a variety of pharmaceutical
treatments, such as antidepressants, anxiolytics, adrenergic inhibitors, mood stabilizers,
and anticonvulsants. Generally, studies have demonstrated that pharmacological therapies
are more effective than placebos at easing PTSD symptoms. Moreover, new medications
that affect traumatic event memory are currently being investigated. For instance,
research on animals has demonstrated that the dopamine D receptor is important in the
PFC's processing of emotional information. It is possible to prevent the experience of
emotional memories by manipulating these receptors.
According to Bisson and Andrew (2007), Bradley, Greene, Russ, Dutra, and
Westen (2005), M. Friedman et al. (2014), Frueh et al. (2018), and Ursano et al. (2008),
cognitive and behavioral therapy are now the most successful treatments for PTSD. In
reality, psychotherapy is the principal mode of treatment for PTSD, one of the DSM
illnesses. The most researched treatments include eye movement desensitization and
reprocessing (EMDR), cognitive behavioral therapy (CBT), and exposure therapy for
post-traumatic stress disorder (PTSD) (EMDR). A controlled re-experiencing of the
original trauma is a crucial component of the majority of therapy. This is known as
catharsis in psychodynamic therapies. The client's role is to relive the initial trauma in a
secure and controlled setting so that its detrimental emotional impact is lessened. Studies
have indicated that therapies are more successful than those that do not when they
concentrate on the trauma the patient experienced. Post-Traumatic Stress Disorder and
Suicide in the Military analyzes the relationship between stress-related illnesses and
suicide in the armed forces.
Narrative exposure therapy (NET) is another method that has been utilized to treat
trauma patients. This strategy is predicated on the notion that the brain's fear/trauma
network accumulates memories of extremely traumatic, stressful, and terrifying
experiences. Although this knowledge is frequently kept without regard to the passage of
time, when it is recalled, it can suddenly seem to be taking place right now. This network
is to be dismantled by NET. The kid, adolescent, or adult is instructed to imagine their
experiences as being along a rope that represents their life in terms of positive and bad
feelings at the beginning of the procedure. The person recounts their most exciting
moments, starting with birth, in the sessions that follow.
A five-session, trauma-focused psychotherapy called written exposure therapy
(WET) asks patients to write about their traumatic experience while following pre-written
instructions. The first session comprises a therapeutic rationale and psychoeducation
about PTSD, followed by 30 minutes of writing. Therapists give feedback to clients
regarding how closely they adhered to the writing instructions during the previous session
and make recommendations for doing so at the start of each subsequent session. After
receiving this criticism, people write uninterrupted for 30 minutes. There are no
homework requirements in written exposure treatment. Therapy with WET has been
proven to be successful.
In EMDR treatment, the patient imagines the traumatic event while moving his or
her eyes. The core tenet is that unexpressed memories in the brain are a factor in PTSD.
With direct processing, therapy aims to bring these dormant memories to the surface. The
patient is instructed to maintain eye contact with the therapist while picturing the event,
and to keep his head steady. The process is repeated until the person is no longer in pain.
Although the method has been demonstrated to be successful in treating PTSD,
neuroscience viewpoints are only now starting to be expressed.
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