Major Achievement of Yoshinori Ohsumi

I want a page of a Nobel Prized Scientist "Yoshinori Ohsumi"'s major achievements,  (NOT a list of awards but a discussion on his/her science or what he/she has done for science); C) a description of the Nobel Prize winning research (behavior) he/she carried out and its scientific (biological/medical) background; D) the major impact of his/her work to biological sciences, particularly to modern genetics/molecular biology; and E) your personal reflection after doing research on the scientist.