MSCI 500 LIBERTY UNIVERSITY Cancer Cell Biology Quiz_PRACTICE MATERIAL_2024.pdf

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Score for this quiz:40out of 40

Submitted Feb 18, 2023 at 6:43pm

This attempt took 31 minutes.

Question 1

2/ 2pts

Cellular senescence plays an important role in in permanently restricting the

propagation of damaged and defective cells.

True

False

Question 2

2/ 2pts

Cellular senescence is a process that is exaggerated in malignant cells and

promotes their division and metastasis.

True

False

Question 3

2/ 2pts

Senescent cells are characterized by a higher content of lysosomes than

non-senescent cells.

True

False

Question 4

2/ 2pts

You are working in a cell biology lab that investigates non-small cell lung

cancer cells, which of these cellular features will be suggestive of

senescence in the cells observed? Choose all that apply:

Large flattened morphology

Reduced incorporation of 5-bromodeoxyuridine (in DNA replication)

Increased p53 expression

Decreased expression of p15INK4B

Question 5

2/ 2pts

Senescence markers are highly exhibited by these groups of cells (Choose all

that apply);

Aged cells

Damaged cells

Malignant cells

Premalignant cells

Question 6

2/ 2pts

Senescent cells usually undergo marked changes in chromatin structure

characterized by densely staining senescence-associated secretory

phenotype.

True

False

Question 7

2/ 2pts

The concept of Hayflick limit states that normal human diploid cells

invariably stop dividing in culture after multiple passages despite optimal

growth conditions.

True

False

Question 8

2/ 2pts

Replicative senescence is a process used by malignant cells to achieve

immortalization by critically shortening the telomeric protective cap of the

DNA.

True

False

Question 9

2/ 2pts

Most normal cells express high levels of the enzyme telomerase (which is

necessary for their survival and proper function) except germ cells and

progenitor cells.

True

False

Question 10

2/ 2pts

Which of these viral proteins is capable of limiting cellular senescence and

inducing malignant transformation in infected cells?

HPV E6

Adenovirus E1A

SV40 large T antigen

All of these

Question 11

2/ 2pts

With respect to the final step of the metastatic cascade, the progression

from micrometastases to macrometastases is the ability of the cells to

withstand the metastatic stress of the new microenvironment.

True

False

Question 12

2/ 2pts

Lysyl oxidase is an enzyme involved in promoting collagen (ECM)

crosslinking and stiffness that is known to be upregulated in breast and colon

cancers to limit metastasis.

True

False

Question 13

2/ 2pts

Which of these describes the role of the ECM in malignant cell metastasis?

Serves as a base for cell anchorage

Helps to determine cell polarity

Releases bioactive molecules/ligands that promote metastasis

All of these

Question 14

2/ 2pts

Tumor-associated eosinophils are the most abundant immune infiltrates in

tumor cells and their presence is associated with increased responsiveness

to chemotherapy and radiotherapy.

True

False

Question 15

2/ 2pts

Which of these statements accurately describes the myeloid-derived

suppressor cells (MDSC) involved in malignant cells invasion and metastasis?

Granulocyte/Polymorphonuclear MDSCs are mature neutrophils that are

more highly phagocytic than the mature neutrophils

Granulocyte/Polymorphonuclear MDSCs express high levels of reactive

oxygen species and myeloperoxidase for immunosuppression

The abundance of MDSCs in tumors is associated with a good prognosis and

increased responsiveness to chemotherapy

MDSCs promote the effects of anti-VEGF drugs by promoting angiogenesis in

tumors

Question 16

2/ 2pts

The sensitivity of a tumor to radiotherapy is related to its proximity to

capillary blood supplywhile cells in the G0/G1 are less sensitive to drugs targeting DNA replication than than cells in S phase.

True

False

Question 17

2/ 2pts

Tumor invasion describes the capacity of a tumor to disrupt the basement

membrane and penetrate the underlying stroma of a tissue.

True

False

Question 18

2/ 2pts

In which of these process do you expect to see a loss of epithelial-specific E

cadherins and a switch from keratin to vimentin as the major intermediate

filament?

Wound healing

Oncogenesis

Embryonic development

All of these

Question 19

2/ 2pts

Which of these factors secreted by tumor cells is not associated with

promoting tumor cell motility during metastatsis?

Lipopolysaccharide A

Lysophospholipase D

Lysophospahtidic acid

Hepatocyte Growth Factor/Scatter Factor

Question 20

2/ 2pts

Which of these is not a common site of uterine endometrial cancer

metastasis?

Brain

Lung

Liver

Ovary

Quiz Score:40out of 40

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