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Write a grant proposal requesting funding to conduct research for the research question of “Is there a significant difference in the clinical outcomes, including mortality rates, reinfarction rates, and long-term quality of life, between patients treated with fibrinolytic therapy and those treated with percutaneous coronary intervention for acute myocardial infarction?”

Please use the template below to organize the grant proposal

· Executive Summary

· Statement of Need

· Project Description

· Conclusion 

· References  (6 references, I have provided some below)

Armstrong, P. W., Gershlick, A. H., Goldstein, P., Wilcox, R., Danays, T., Lambert, Y., Sulimov, V., Rosell Ortiz, F., Ostojic, M., Welsh, R. C., Carvalho, A. C., Nanas, J., Arntz, H. R., Halvorsen, S., Huber, K., Grajek, S., Fresco, C., Bluhmki, E., Regelin, A., Vandenberghe, K., … STREAM Investigative Team (2013). Fibrinolysis or primary PCI in ST-segment elevation myocardial infarction. The New England journal of medicine, 368(15), 1379–1387. https://doi.org/10.1056/NEJMoa1301092

Joy, E. R., Kurian, J., & Gale, C. P. (2016). Comparative effectiveness of primary PCI versus fibrinolytic therapy for ST-elevation myocardial infarction: a review of the literature. Journal of comparative effectiveness research, 5(2), 217–226. https://doi.org/10.2217/cer-2015-0011

Karha, J., & Topol, E. J. (2006). Primary percutaneous coronary intervention vs. fibrinolytic therapy for acute ST-elevation myocardial infarction in the elderly. The American journal of geriatric cardiology, 15(1), 19–21. https://doi.org/10.1111/j.1076-7460.2006.05290.x

Krittanawong, C., Hahn, J., Kayani, W., & Jneid, H. (2021). Fibrinolytic Therapy in Patients with Acute ST-elevation Myocardial Infarction. Interventional cardiology clinics, 10(3), 381–390. https://doi.org/10.1016/j.iccl.2021.03.011

McClelland, A. J., Owens, C. G., Walsh, S. J., McCarty, D., Mathew, T., Stevenson, M., Gracey, H., Khan, M. M., & Adgey, A. A. (2005). Percutaneous coronary intervention and 1 year survival in patients treated with fibrinolytic therapy for acute ST-elevation myocardial infarction. European heart journal, 26(6), 544–548. https://doi.org/10.1093/eurheartj/ehi149

Note: You do not need to provide research budgets/financials and organizational information which is covered in the tutorial.

GrantProposalExampleTemplate.pdf

Running Head: GRANT PROPOSAL EXAMPLE 1

Grant Proposal Example

Joe S. Awesome

University of West Florida

College of Arts and Sciences

School of Allied Health and Life Sciences

HSC 4050 – Health Science Research Seminar

Section 1234

Dr. B. Instructor

September 24, 2013

GRANT PROPOSAL EXAMPLE 2

Executive Summary

The executive summary is the first section read by the individuals or committee members

screening hundreds or thousands of grant requests. The executive summary is the first screening

you must pass through for further consideration. If the executive summary does not provide

sufficient information in a concise manner and isn’t relevant for the decision maker, your

proposal will likely be tossed out of the competition for funding. Executive summaries are

directed toward the busy chief executive of the funding organization. The length should not be

more than one page

Your executive summary should include the following: (1) topic sentence, (2) clearly and

concisely stated purpose of your proposal, and (3) stated thesis. You should include at least three

supporting sentences which should answer who wants to do what, where, when, how (research

method you will use) and why (importance of your research). Make a convincing

argument/proposal as to why this funder should fund your research over other applicants. You

should write your executive summary last because it should sensibly be connected to other

sections of your proposal. Your executive summary should be similar to your last section

(conclusion/summary section).

GRANT PROPOSAL EXAMPLE 3

Statement of Need

State the need in the community or health care setting that your research will fulfill. Provide

background information to your specific project (Hint: Use your literature review). Include

evidenced based decisions for why your research will (re)solve an existing or potential problem

or gap you identified during your review of the literature on this topic. Use correct APA citations

to mention the most relevant items or facts you found and how they led you to propose your

hypothetical research project.

Background

The statement of need section should be at least one page long in order to provide

sufficient history of other research conducted on this topic, or the lack of research, which led

you to want to conduct research to add to the existing body of knowledge. You will find writing

this section somewhat familiar, it is very similar to a short form of the literature review you just

finished. While you should not cut and paste your entire literature review here, you may certainly

use parts of it. If there is a dearth of literature, your project can propose a novel remedy/solution

to solve a health science problem. Executive really like to make their mark by having their name

attached to a great solution, treatment, or therapy.

This section sets up the specifics of your proposal, especially how you’ll conduct your

research which is discussed in the project description. As you assess and analyze the review of

literature, or previously conducted research, you should evaluate the original source’s:

 Topic

 Goal

 Study purpose

 Study objectives

 Operational definitions if necessary to define variables or health outcomes under

investigation

 Research method utilized

 Measured outcomes

 Study strengths and limitations

 Report main points/arguments

 Assessment of source’s reliability and biases

 Usefulness to your research compared to others sources included in the reference section

Students should evaluate how the article/source fits within your topic of interest, how the

research has shaped your argument, and how you think about the topic (importance,

challenges, etc.)

GRANT PROPOSAL EXAMPLE 4

Project Description

In this section you will provide specific information regarding your proposal including:

 Who is conducting the research

 Where is the research being conducted

 Study duration or time period

 How the study is being conducted (describe which study design is being used)

 Why is the proposed research design being used?

The project description should be at least one page but less than three pages in length.

Your proposed research design type (cohort, case-control, etc) should be clearly stated. We’ve

listed some useful guides for you in designing your design type. Please choose one design from

the following examples.

 Here are considerations you should be aware of when setting up a Cohort Study Design.

 Here are considerations you should be aware of when setting up a Case-control Study

Design.

 Here are considerations you should be aware of when setting up a Randomized

Controlled Trial.

 Here are considerations you should be aware of when setting up a Practice Guideline. A

good example of practice guidelines are recommendations put forth by the United States

Preventive Services Task Force (USPSTF), such as Breast Cancer Screening Guidelines

(mammograms) .

 Here are considerations you should be aware of when setting up a Systematic Review.

 Here are considerations you should be aware of when setting up a Meta-Analysis.

Include epidemiological terms you learned during this course, particularly descriptive

epidemiology describing person, place, and time specifics of your proposed study. You will need

to be persuasive in presenting your proposal, remember, you are arguing in favor of your

research proposal over a plethora of other submissions. Grant funding is extremely competitive!

Use of Descriptive Epidemiology in your proposal

Researchers

You want to describe the use of minimal research personnel in your organization (you),

as well as existing secondary data sources. There are plenty of secondary data sources (data

gathered by federal and state organizations and agencies), which you can download and use,

however, remember there are benefits and limitations. Using clinicians in your study increases

their work burden as well as drains on your financial resources.

Population

GRANT PROPOSAL EXAMPLE 5

Describe the population, including population characteristics, under study in your

research project.

Place

State the geographical location your population resides and where they access their health

care (hospital, outpatient facility, nursing home, etc). State where the intervention program will

be conducted and the duration of the intervention (6 months, 1 year, etc.).

Supplies/Equipment

State the supplies or medical equipment needed for your research, as well as software you

may need to access sources of data. Examples of equipment and supplies include medications,

transport vehicles, needles, computer software, etc.

Financials

Although financial budgets were discussed in the tutorials you do not need to include

financial information or research budgets for your project. Development of budgets is beyond the

scope of this course.

GRANT PROPOSAL EXAMPLE 6

Conclusion

The summary is the final portion of your grant proposal. It is important to describe how

the findings of your study will contribute to the larger and existing body of knowledge that

currently exists in your area of study. The conclusion is a last, closing remark which should

remind the reader and evaluators of grant proposals that your research or project will increase

some benefit both to patients and the funder(s). The conclusion should be less than one page in

length.

GRANT PROPOSAL EXAMPLE 7

References

Place references in alphabetical order per APA format. You need to include at least 6 scholarly

journal articles for this project. A review of APA reference style and formatting can be found

Module 6, Lesson Topic 2