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Reilly, Philip R. Is it in Your Genes?: The Influence of Genes on Common Disorders and Diseases that Affect You and Your Family. New York: Cold Spring Harbor Laboratory Press. 2004. Print.

In pages 162-168 of his book, Reilly explains how testing positive for BRCA1/2 increases a person’s risk for breast cancer. He begins by explaining the different types of breast cancer and the various risk factors such as age, ethnicity, pregnancy and menopause. Reilly continues by detailing the process by which researchers discovered breast cancer genetic mutations and the risk involved with having one. Women who test positive for BRCA1/2 have a much higher risk in their lifetime for developing both breast and ovarian cancer. Reilly does note that there has been some controversy on whether or not women should be tested for these genes. Some people feel that women should not participate in such an expensive test (at the time it cost $2500) because all women should see themselves at some risk for developing cancer and should have regular checkups and screenings regardless of an increased genetic risk. However, Reilly points out that for those women who are already at a heightened risk due to a family history of breast or ovarian cancer the test can prove that they may not have the genetic mutation for an even higher risk. If a woman has already tested positive for BRCA1/2 then the test is even more helpful for her family members who have a 50-50% chance of inheriting it. Reilly continues by discussing the various preventative measures for a woman who tests positive such as prophylactic surgeries. One interesting note Reilly examines is the fact that Ashkenazi Jews have about three times more risk of having this genetic mutation than Caucasians do. This has been attributed to differences in food and geographical location. Researchers have not yet been able to figure out what constitutes high enough risk factors to condone such an expensive medical test. It is for this reason that Reilly encourages women to always seek out genetic counseling prior to having the test. If a woman’s family history does not indicate very high risk, then she should most likely avoid genetic testing. He also includes a detailed table that gives specific examples of what family history would constitute good reasons to seek out genetic testing.

This source related quite well to my topic as it discussed in detail what family history and risk factors should motivate a woman to seek genetic testing. This book was written to the average person, and is easily understandable with helpful insights for women. It was published in 2004, and while the medical and social aspects have not changed much, one significant change has been in the cost of genetic testing. The book states that the genetic test for both breast cancer genes costs about $2500, whereas in 2013 this cost has decreased to around $800-$1000. Although insurance will usually cover the cost of the test, the decrease in cost is quite a significant factor that would affect a woman’s decision to be tested. This in turn decreases the quality of the source for my topic because important financial information has updated since then. The author, Philip Reilly is a doctor who attended the American College of Medical Genetics and has written five books about genetics, making him well qualified as an authority on this subject. Although breast cancer genetics is only covered in seven pages, the information provided is beneficial to all women, and because it was written to the common man it is easy to comprehend. (LN) this is the evaluation