· One thousand people are enrolled in a 10-year cohort study. At the start of the study,

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· One thousand people are enrolled in a 10-year cohort study. At the start of the study, 100 have diagnosed CVD. Over the course of the study, 80 people who were free of CVD at baseline develop CVD.

1. What is the cumulative incidence of CVD over 10 years?

Cumulative Incidence 10 Years =

2. What is prevalence of CVD at baseline?

Prevalence Baseline =

3. What is the prevalence of CVD at 10 years?

Prevalence 10 Years =

· A study is deigned to investigate whether there is a difference in response to various treatments in patients with rheumatoid arthritis. The outcome is a patients self-reported effect of treatment. The data are shown above. Are symptoms independent of treatment? Conduct a Chi Square test at a 5% level of significance.

	Symptoms worsened	No effect	Symptoms improved	total
Treament1	22	14	14	50
Treatment 2	14	15	21	50
Treatment 3	9	12	29	50

1. df=

2. Critical value

3. Computed statistic

Based on comparing the computed statistics to the critical value which of the following are true?

a. There is significant evidence , alpha 0=0.05, to show that treatment and response are not independent

b. There is not significant evidence, alph=0.05, to show that treatment and response are not independent

c. There is significant evidence, alpha =0.05, to show that treatment and response are independent

d. B and c