BIOL

BIOL 439

Problem Set 1

10 points

Due 7/27/15 in class (-2 pts per day late)

Given the following: You have a [hormone]plasma = 1 µM, which is 60 % bound by plasma proteins. The liver enzyme responsible for metabolizing this hormone does so at a constant rate per [hormone]; i.e., the enzyme follows first-order kinetics. The decay constant, kel, is 0.578. Calculate the t1/2 and then determine the [hormone]plasma 6 half-lives later. Fill in the following table below.

Is this hormone more likely to be H2O-soluble or lipid-soluble? ____________________

t1/2 = __________________

Number of half-lives	Time passed	[Hormone]plasma
1
2
3
4
5
6

Assume no significant further hormone synthesis and secretion is occurring at this time.