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1.

The significance of the story The Metamorphosis is that the boy Gregor was left alone, and died alone. He was the sole provider for his family due to the debt that the family was in, so Gregor had to work , to work the debt off the family owed. The mother strayed away from her own son because of the way he turned into a monstrous cockroach.  He turned into The family would not go near him to the point the mother slid his food under the door. None of the family members would even go near him, except the sister did do for him what she could.He was basically abandoned in his own home because of what he turned into, which was not his fault. Gregor's belongings in his room was also taken, due to the family not wanting Gregor to touch anything in the house because they were scared. No one should have to be alone. Gregor needed his family support more than ever at this time no matter how he looked. He was still a member of the family. The family tried to accept his physical state but could not adjust to well. Gregor did die at the end, and he had died alone 

Franza Kafka, Metamorphosis and Other Stories, Penguin Classics Deluxe Edition, 2008

2.

Death and neglect. Death and neglect are the significance in the end of this story. The main character when through a drastic change physically in the beginning of this story and just like any other time and place the reaction is all ways the same. The people closes to you do not know how to react to the change. Throughout the writing you find that there is all ways one individual in the family that breaks down and assumes the round of the care giver and protector like the sister did. However like the story in today's world people will become tired and distance from the change and the neglect starts to play a bigger role into what ultimately becomes depression.  This really effects the minds set of the person in which the change happen. Just like today and the suicide rate that is pretty outrageous. The control that an outside person has can really be seen and with the person already beginning mentally tired death becomes easily the next step. The family in this story could not in the beginning come to understand the change, but the sister tried to relate. Although due to the look of the bug made things pretty difficult for her and everyone else. Once death came into the picture the family did the best thing that anyone  who had lose someone could do and this was move on with the rest of their live only the remember the good time and not reflect on the bad.