biology

Yerisinia enterocolitica hear bored by pigs

Under cooked pork

During slaughter

Improper food handling

Healthy adults --- gastro

Interaction between bacteria and host cell (intestine )

Inside the cell of intestine yisin uses molecule syring to inject bacteria (called effector)

To know how to develop

Yspl interacts with mammalian protein

How to determine protein interaction

Using a mixture of yeast and human cell

FAK is targeted by those yspl : fak regulates cellular function , affects cell movement

Fak functions at focal adhesions

Focal adhesion : contains many proteins

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How yspl function at focal adhesion

Hypothesis : yspl localizes to focal adhesion

It doesn't interact with FAK

But yes yspl localizes it focal adhesion

So as a result yspl affects cell movement

Yspl reduces FAK and inhibits cell migration

Neutrophil chasing bacteria