Genetics of Inherited Traits Presentation

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Genetics of Inherited Traits Learning Team Presentation

Topic: Each person will be assigned a unique topic related to the genetic inheritance of traits and diseases. The topics include:

1. Autosomal dominant inheritance

2. Autosomal recessive inheritance

3. Genomic imprinting and dynamic mutations

4. X-linked inheritance

5. Autosomal aneuploidy

6. Sex chromosome aneuploidy

7. Congenital abnormalities arising at the fetal stage

8. Common disorders of adults (ex. breast cancer-BRCA I/II, hyperuricemia and gout, familial hyperlipidemia/dyslipidemia, Li Fraumeni syndrome, Lynch syndrome)

9. Environment related polymorphisms (ex. Malaria and sickle cell disease – if you select this topic, you need to focus on more than the mutation, the presentation needs to include a discussion of selective pressures promoting maintenance of certain genetic mutations)

INVESTIGATE the National Human Genome Research Institute

http://www.genome.gov/10001204

Access the Human Genome Project Archive: http://genomics.energy.gov

Investigate further through other credible sources (UOPx Library, professional organizations related to your topic, government sites) for additional information on your assigned topic.

· Helpful website:

· Issues in genetics: http://www.genome.gov/Issues/

· Genetic testing: http://www.genome.gov/10002335

· Online genetics education resources: http://www.genome.gov/10000464

· Health issues in genetics: http://www.genome.gov/10001872

For this assignment, you will investigate one genetic pattern of inheritance. Each type of inheritance can be passed through a family that may increase a person’s risk of developing disease at some point in life. You will prepare a PowerPoint presentation to be delivered during week two.

This activity is as follows:

1. Describe the inheritance pattern that you were assigned.

2. Research and describe the genetic process responsible for transmission between generations, and identify one disease or condition that can results when defective (mutant) genes are transmitted between generations. You might find it helpful to include a graphic explaining how a deleterious gene is transmitted between generations. This is known as a pedigree. Consider where the gene is located (autosome or sex chromosome, whether the mutation is dominant or recessive, what happens in the carrier state).

3. Describe how this type of inheritance of a mutant gene might affect a person’s anatomy and physiology (what is the disease, what organs does it affect, what complications can it cause, and why?).

4. Discuss the probability of inheriting the disease (disease development can be dependent on whether the mutation is dominant, recessive or sex-linked). Are there any credible genetic tests available to determine carriers of the condition? If so, how accurate are they and what does the data indicate about the number of people in the US affected by this condition?

5. Personal perspective:

a. What did you learn from this assignment?

6. References (you should include the links from above and your textbook, at a minimum)

7. Format the information as a Microsoft PowerPoint presentation with 8-12 slides (approximately – more is always better than less) and speaker notes.

8. In-class overview: Students will present their findings to the class as part of their score on the assignment.

This assignment is due in Week Two

Content 80 Percent	Points Available 8	Points Earned X/8	Additional Comments:
· Each of the following concepts is addressed thoroughly, including the basics of the concepts followed by how the source helped you better understand the issue. Introduction · Background on your inheritance pattern Genetics of transmitting genes to offspring – pattern of inheritance · How are mutations transmitted from parents to offspring for this condition Potential Consequences of deleterious mutations arising from this mode of genetic transmission · Discuss a potential disease or condition resulting from this type of genetic transmission of mutant genes Probability of inheritance · If a parent has a mutation (or both parents), what is the likelihood of offspring developing the same problems Personal perspective · What did you learn by this assignment? Conclusions · Key Points/Recommendations fully researched and documented on the slides References · Sources properly cited within presentations (on slides) · Must include at least 2 sources other than the text that are peer reviewed; you should include information from the human genome project Speaker Notes · Added substantial content to presentation · Included appropriate citations
Style, Mechanics and Organization 20 Percent	Points Available 2	Points Earned 2	Additional Comments:
Speaker skills · Avoided reading from notes · Spoke in a clear voice · Transitioned well between speakers Organization of the Presentation · Stimulated the interest of the audience · Presentation thesis, or main point of the discussion, was clearly evident · Structure and flow was clear, logical, and transitioned from opening body to conclusions · Conclusions and recommendations summarized key points of the discussion Visual Aids · Presentation was evenly distributed among speakers · Visual aids and handouts were appropriate for the content. Visual aids (including PowerPoints) were clear, concise and uncluttered Overall · Presentation included speaker notes · Audience was engaged and appeared interested in the presentation · Speaker appeared genuinely interested in the subject matter
	Total Available	Total Earned
Overall Comments	10

Version 2.0

June 2014