10 page paper

· The need of Tissue Engineering (Tissue Engineering: current strategies and Future directions)

· Lack of organ donors

· Assist in lung tissue regeneration

· What my paper discusses (Tissue- Engineered Lungs for in Vivo Implantation)

· Lung implants in rats, shows promise but there are a few set backs

· The result of the scaffold that lung stem cells may adhere too

· What is a scaffold and why is it important?

· Important for cell adhesion, specifically stem cells

· Leaves a structure of that still has the extracellular matrix

· Gives way for branching of the lungs, critical for successful lung transplantation.

· Recipient of tissue engineered tracheal replacement (Engineering tissues for children: building grafts that grow)

· Discuss why it worked

· Also discuss how this paper can be used to discuss improvements for the primary source.

· Issues with tissue engineered: biocompatibility

· There could be negative side effects, such as chemical breakdowns that could lead to degrading interactions

· Immunological effects (biocompatibility of implants: lymphocyte/ macrophage interactions)

Summary

This article is about using in vitro techniques to regenerate lung tissue from adult rat. Because the only way to repair lung tissues is to do a lung transplants in the human body, which cost money, time and the need for a donor. This new methods has been an advance in technology and science to be able to produce a new lung that is functional (at least in experimental procedure) so far for scientist to expand it to experimentation on human lungs tissue to see what the results would be like. The experiment they did in this article shows, the removal of cellular components and leaving only the extra cellular matrix, it was able to reform its structure and airways and was involved in gas exchanged when put back into the adult rat.

Reference:

Anderson, J., McNally, A. 2011. Biocompatibility of implants: lymphocyte/ macrophage interactions. Semin Immunopathol. 33:221-223

Elliott MJ, De Coppi P, Speggiorin S., et al. 2012. Stem-cell-based, tissue engineered tracheal replacement in a child: a 2-year follow-up study. Lancet 380(9846): 15-21.

Olson, J., Atala, A., Yoo, J. 2011. Tissue Engineering: Current strategies and Future Directions. Chonnam Medical Journal 47(11): 1-13

Petersen, T., Calle, E., Zhao, L., Lee, E., et al. 2010. Tissue- Engineered Lungs For in Vivo Implantation. Science. 329: 538- 541.