PSYC 676 Developmental Neuropsychology

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 Language Development and Dysfunction 

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LiteratureReviewPaperThesisandListofReferencesExample.docx

Neurobiological Substrates of Obsessive-Compulsive Disorder

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Department of Psychology, Liberty University

( NEUROBIOLOGY OF OCD ) ( 2 )

Thesis Statement

Empirical evidence suggests that Obsessive-Compulsive Disorder (OCD) is related to neuroanatomical and neurofunctional abnormalities in specific brain pathways involved in information processing, behavioral initiation, and behavioral inhibition.

References

Baxter, L.R., Schwartz, J.M., Mazziotta, J.C., Phelps, M.E., Pahl, J.J., Guze, B.H. & Fairbanks,

L. (1998). Cerebral glucose metabolic rates in nondepressed patients with obsessive– compulsive disorder. American Journal of Psychiatry, 145, 1560–1563. https://doi.org/10.1001/archpsyc.1990.01810210048007

Baxter, L.R., Schwartz, J.M.; Bergman, K.S., & Szuba, M.P. (1992). Caudate glucose metabolic rate changes with both drug and behavior therapy for obsessive–compulsive disorder. American Journal of Psychiatry, 49(9), 1559–1563. https://doi.org/10.1016/S0925-4927(99)0051-7

Busatto, G.F., Zamignani, D.R., Buchpiguel, C.A., Garrido, G.E.J., Glabus, M.F., Rocha, E.T., Maia, A.F., Rasario-Campos, M.C., Castro, C.C., Furuie, S.S., Gutierrez, M.A., McGuire, P.K., & Miguel, E.C. (2000). A voxel-based investigation of regional cerebral blood flow abnormalities in obsessive–compulsive disorder using single photon emission computed tomography (SPECT). Psychiatry Research: Neuroimaging, 99(1), 15–27. https://doi.org/10.1016/S0925-4927(00)00050-0

Ebert, D., Speck, O., Konig, A., Berger, M., Hennig, J., & Hohagen, F. (1997). 1H-magnetic resonance spectroscopy in obsessive–compulsive disorder: Evidence for neuronal loss in the cingulate gyrus and the right striatum. Psychiatry Research: Neuroimaging, 74, 173– 176. https://doi.org/10.1016/S0925-4927(97)00016-4

Hansen, E.S., Hasselbalch, S., Law, I., & Bolwig, T.G. (2002). The caudate nucleus in obsessive–compulsive disorder. Reduced metabolism following treatment with paroxetine: a PET study. International Journal of Neuropsychopharmacology, 5, 1–10. https://doi.org/10.1017/S1461145701002681

Nordahl, T.E., Benkelfat, C., Semple, W.E., Gross, M., King, A.C., & Cohen, R.M. (1998).

Cerebral glucose metabolic rates in obsessive compulsive disorder.

Neuropsychopharmacology, 2, 23–28. https://doi.org/10.1016/S0925-4927(99)00040-2