CASE STUDY ANALYSIS

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week4pathocasestudy.docx

week 4

Week 4 Case Study Prompt (Student version) A 67-year-old man presents with progressive shortness of breath over 8 months. He  reports: • Increasing dyspnea with exertion • Dry, persistent cough • Fatigue • Decreased exercise tolerance • Unintentional 10-pound weight loss He denies wheezing, chest pain, fever, or recent respiratory infection. Past medical history includes hypertension and hyperlipidemia. He is a retired  construction worker with 35 years of occupational dust exposure. He smoked 1 pack per  day for 25 years but quit 10 years ago. Physical Examination • BP: 132/78 mmHg • HR: 88 bpm • RR: 20/min • SpO₂: 91% on room air Lung exam reveals: • Fine, bilateral “Velcro-like” crackles at the lung bases • No wheezing • Digital clubbing present Cardiac exam normal. No peripheral edema. Diagnostic Data Pulmonary Function Tests (PFTs): • Reduced total lung capacity (TLC) • Reduced forced vital capacity (FVC) • Normal or increased FEV1/FVC ratio • Decreased diffusion capacity (DLCO) Chest X-ray: Bilateral interstitial markings, worse at lung bases High-Resolution CT (HRCT): • Reticular opacities • Honeycombing pattern • Subpleural and basilar predominance Laboratory Findings: Test Result CBC Normal CMP Normal ANA Negative Rheumatoid factor Negative ESR Mildly  elevated Questions 1. Develop a 1- to 2-page case study analysis, examining the patient signs  and symptoms presented in the case study; discussing the primary  cellular pathophysiological processes, and the significance for  symptom development and diagnosis. 2. What role do genetic mutations play in the development of the disease? 3. What are the racial/ethnic factors that would be a risk factor? What are  the lifestyle risk factors?

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