CASE STUDY ANALYSIS

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Week2PATHOCaseStudyPrompt.docx

Week 2 Case Study Prompt  A 28-year-old African American woman presents with 4 months of worsening fatigue, joint  pain, and intermittent low-grade fevers. She reports: • Symmetrical pain and stiffness in hands and wrists (morning stiffness ~1 hour) • Photosensitivity • Facial rash that worsens with sun exposure • Hair thinning • Bilateral ankle swelling No recent infection. No new medications. Physical Examination • BP: 148/92 mmHg • Temp: 99.4°F • Erythematous malar rash sparing nasolabial folds • Tender MCP and PIP joints bilaterally • Mild bilateral ankle edema Laboratory Data Test Result Hgb 9.8 g/dL WBC 3,000/mm³ Platelets 110,000/mm³ Creatinine 1.6 mg/dL Urinalysis 2+ protein, RBC casts ESR 65 mm/hr ANA Positive (1:640) Anti-dsDNA Elevated Anti-Smith Positive Complement C3/C4 Decreased Questions:  1. Develop a 1- to 2-page case study analysis, examining the patient signs and  symptoms presented in the case study; discussing the primary cellular  pathophysiological processes, and the significance for symptom development and  diagnosis. 2. What role do genetic mutations play in the development of the disease? 3. What is the impact of the disease on the immune system? How do treatment  strategies target the pathophysiological mechanisms of the disease

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