3-2 Discussion: Respiratory Disorders
CYSTIC FIBROSIS
Concept Etiology: How does the disease affect the respiratory
system in particular?
The abnormal electrolyte transport system in CF causes the cells in
the respiratory system, especially the lungs to absorb too much
sodium and water. It causes the thin secretions in the lungs to
become very thick and hard to move. Theses thick secretions
increase the risk for frequent respiratory infections.
How does it deviate from the definition of health discussion in
module one?
This disorder really doesn’t deviate with health because it can be
involved with the born of a child before adulthood so the body is
already malfunctioning. So keeping up the health body determine
extra measures that will keep both balanced.
Classification: How is the disease classified?
The traditional classification of CF mutations based on their cellular
phenotype. Class I protein synthesis defect and Class II maturation
defect; Class III gating defect Class IV conductance defect, Class V
reduced quantity and Class VI reduced stability.
Clinical Manifestations: (Symptoms and Signs)
(Symptoms)Thick mucus that clogs certain organs, such as lungs,
pancreas and intestines. This may cause malnutrition, poor growth,
frequent respiratory infections and breathing problems and chronic
lung disease. (Sign) Diarrhea that does not go away, foul-smelling
stools, skin that tastes like salt, persistent cough and poor growth
despite having a good appetite.
Diagnostic Test: Chest X-rays, Ultrasound and CT scans, blood test,
Lung function test and Sputum cultures and stool test also, newborn
screening and a sweat chloride test
JohnHopkins (n.d). Cystic Fibrosis.
Health https://www.hopkinsmedicine.org/health/conditions-and-
diseases/cystic-fibrosis
Drubin,D.G.,(2016). From CFTR Biology toward Combinational
Pharmacotherapy: Expand Classification of Cystic Fibrosis Mutations.
Molecular Biology of the Cell. 27(3) 424-
433 https://doi.101091/mbc.E14-04-0935
