Liberty University
Master of Public Health
HLTH
Research Paper: References and Annotated Bibliography
Strategies to Control Dengue Virus
References
1. Sim S, Ng LC, Lindsay SW, Wilson AL. A greener vision for vector control: The example
of the Singapore dengue control programme. PLoS Negl Trop Dis. 2020;14(8):e0008428.
Published 2020 Aug 27. doi:10.1371/journal.pntd.0008428
2. Rather IA, Parray HA, Lone JB, et al. Prevention and control strategies to counter dengue
virus infection. Front Cell Infect Microbiol. 2017;7:336. Published 2017 Jul 25.
doi:10.3389/fcimb.2017.00336
3. Horstick O, Boyce R, Runge-Ranzinger S. Building the evidence base for dengue vector
control: searching for certainty in an uncertain world. Pathog Glob Health.
2018;112(8):395-403. doi:10.1080/20477724.2018.1547541
4. Buhler C, Winkler V, Runge-Ranzinger S, Boyce R, Horstick O. Environmental methods
for dengue vector control - A systematic review and meta-analysis. PLoS Negl Trop Dis.
2019;13(7):e0007420. Published 2019 Jul 11. doi:10.1371/journal.pntd.0007420
5. Hladish TJ, Pearson CAB, Toh KB, et al. Designing effective control of dengue with
combined interventions. Proc Natl Acad Sci U S A. 2020;117(6):3319-3325.
doi:10.1073/pnas.1903496117
6. Jain S, Sharma SK. Challenges & options in dengue prevention & control: A perspective
from the 2015 outbreak. Indian J Med Res. 2017;145(6):718-721.
doi:10.4103/ijmr.IJMR_1325_16
7. Pang T, Mak TK, Gubler DJ. Prevention and control of dengue-the light at the end of the
tunnel. Lancet Infect Dis. 2017;17(3):e79-e87. doi:10.1016/S1473-3099(16)30471-6
8. Rawson T, Wilkins KE, Bonsall MB. Optimal control approaches for combining
medicines and mosquito control in tackling dengue. R Soc Open Sci. 2020;7(4):181843.
Published 2020 Apr 22. doi:10.1098/rsos.181843
9. Wilder-Smith A, Tissera H, AbuBakar S, et al. Novel tools for the surveillance and
control of dengue: findings by the DengueTools research consortium. Glob Health
Action. 2018;11(1):1549930. doi:10.1080/16549716.2018.1549930
10. Ouédraogo S, Benmarhnia T, Bonnet E, et al. Evaluation of effectiveness of a
community-based intervention for control of dengue virus vector, Ouagadougou, Burkina
Faso. Emerg Infect Dis. 2018;24(10):1859-1867. doi:10.3201/eid2410.180069
Annotated Bibliography
1. Sim S, Ng LC, Lindsay SW, Wilson AL. A greener vision for vector control: The example
of the Singapore dengue control programme. PLoS Negl Trop Dis. 2020;14(8):e0008428.
Published 2020 Aug 27. doi:10.1371/journal.pntd.0008428
This article highlights the national dengue control program in Singapore which
was established in line with the World Health Organization’s Global Vector Control
Response (GVCR) strategy. The program provides a great example of the GVCR
approach and is in line with the country’s vision of achieving a green and clean
environment which is sustainable for all residents. The author’s note that Singapore has
reduced the incidence of dengue 10-fold since the inception of this program sixty years
ago. Important factors that drove success in this program includes the consideration of
dengue infection as a disease of environmental significance and a focus on environmental
management methods as the main strategy for dengue vector control. The authors also
note that the program has encountered and still has several climate challenges including
manpower constraints and low levels of herd immunity. The authors conclude that lessons
learned from this program can be easily applied in other countries for a more effective
control strategy.
2. Rather IA, Parray HA, Lone JB, et al. Prevention and control strategies to counter dengue
virus infection. Front Cell Infect Microbiol. 2017;7:336. Published 2017 Jul 25.
doi:10.3389/fcimb.2017.00336
The authors of this article outline some key prevention strategies to counter
dengue virus, which tis the most rapidly spreading vector-borne viral infection in North
and South America. They also focus on some broad-spectrum techniques, that are
environmentally friendly and sustainable, efficient, cost-effective, and sustainable. One of
these strategies is the development of immunotherapies and vaccines which have resulted
in the creation of a new dimension for effective prevention and control of dengue
infection. The authors of the article also spend some time discussing the control and
preventive strategies that are currently used to counter dengue infections, including the
implementation of new biological and technological interventions, such as the novel
paratransgenesis, use of genetically modified vectors and the sterile insect technique. The
authors conclude the article by noting that the most effective method of treating dengue
infections so far, which is also a control strategy is the use of tetravalent dengue.
3. Horstick O, Boyce R, Runge-Ranzinger S. Building the evidence base for dengue vector
control: searching for certainty in an uncertain world. Pathog Glob Health.
2018;112(8):395-403. doi:10.1080/20477724.2018.1547541
The authors of this article discuss some chemical and biological methods used in
dengue vector prevention and control. They utilize systematic reviews, meta-analyses,
and recently emerging evidence on public health recommendations for Aedes aegypti
control. This is becoming increasingly relevant in the current era of widespread zika and
yellow fever outbreaks. The framework follows an a priori analysis of systematic reviews
by the authors on distinguishing vector prevention strategies into chemical,
environmental and biological methods. The authors summarize the findings of published
systematic review and compare them with those from the meta-analyses. A total of two
meta-analyses and nine systematic reviews were reviewed to provide some evidence that
chemical methods, especially the use of insecticide treated nets and indoor residual
spraying can effectively control Aedes aegypti and other vectors of dengue virus. The
authors conclude by recommending that studies like this should include metrics of human
transmission data when and where possible.
4. Buhler C, Winkler V, Runge-Ranzinger S, Boyce R, Horstick O. Environmental methods
for dengue vector control - A systematic review and meta-analysis. PLoS Negl Trop Dis.
2019;13(7):e0007420. Published 2019 Jul 11. doi:10.1371/journal.pntd.0007420
The authors of this article intended to perform a meta-analyses and systematic
review of the effectiveness of certain environmental methods for the prevention of
control of dengue vectors. They conducted a literature review using the Cochrane
Library, EMBASE, LILACS, PUBMED and Google Scholar following the PRISMA
guidelines and performed quality assessment using the CONSORT 2010 checklist. They
identified 19 studies which were eligible for the systematic review and 16 for the meta-
analysis. The authors also calculated the difference-in-differences for the meta-analyses,
the difference-of-endlines, the pupae per person index and the Breteau index. Both the
meta-analyses and systematic review showed a very weak effect of the dengue control
interventions on Aedes larval populations and did not find any differences between the
results of each method. They concluded that although each of the environmental methods
was effective in reducing papal and larval densities of Aedes mosquitoes, there is a need
for more studies that adequately compares more meta-analyses and systematic reviews to
strengthen this evidence.
5. Hladish TJ, Pearson CAB, Toh KB, et al. Designing effective control of dengue with
combined interventions. Proc Natl Acad Sci U S A. 2020;117(6):3319-3325.
doi:10.1073/pnas.1903496117
The authors of this article evaluated management options for dengue virus in a
dengue-endemic setting, particularly those combining vaccination and new vector control
methods. Their intervention models were informed by trial outcomes testing guidance for
the only currently licensed dengue vaccine and targeted indoor residual spraying. The
authors found that when combined, these methods outperforms when either is used alone
in an intervention. They also discovered that the conventional model hypothesized for in-
development vaccines, performs synergistically with targeted indoor residual spraying,
and amplifies effectiveness well beyond the independent impacts of each method in
isolation. In addition, the authors found that a large-scale campaign of routine vaccination
and aggressive new vector control resulted in short-term vector elimination with a
complete absence of cases for 10 years even with continuous dengue reintroduction. The
authors conclude by noting that less ambitious implementations of this combination still
resulted in longer-lasting and amplified effectiveness individual-approach interventions.
6. Jain S, Sharma SK. Challenges & options in dengue prevention & control: A perspective
from the 2015 outbreak. Indian J Med Res. 2017;145(6):718-721.
doi:10.4103/ijmr.IJMR_1325_16
The author here examines some challenges in dengue control and prevention as
the disease continues to involve newer geographical areas and expand in populations in
which it already exists. He notes that even though dengue is associated with low
mortality in India, huge financial resources may ultimately be needed for effective
dengue control, just like in other developing countries. The author also emphasizes that
advancements in dengue prevention will have to parallel the advancements in dengue
case management for effective control of the deadly virus. He strongly believes that
massive release of Wolbachia-infected mosquitoes, through the use of sterile insect
technology, and the use of lure-and-kill devices in India to entrap and eliminated dengue
virus vectors is a promising solution to dengue in India. He concludes by emphasizing the
importance of having a strong intersectoral coordination to improve implementation of
current preventive measures - one of the key factors to ensure success in programs like
this.
7. Pang T, Mak TK, Gubler DJ. Prevention and control of dengue-the light at the end of the
tunnel. Lancet Infect Dis. 2017;17(3):e79-e87. doi:10.1016/S1473-3099(16)30471-6
Advances in the production of novel tools for dengue prevention and control have
ushered in a new era of critically needed strategies to reduce dengue transmission and
infections. The burden of dengue infections has expanded for more than sixty years and
currently affects over 100 countries around the world. Complex, global forces will
continue to contribute to dengue virus proliferation, including rapidly expanding and
unplanned urbanization, population growth, and less than optimal control of Aedes
aegypti and other dengue vectors in urban areas. There is now new optimism since the
licensure of the first dengue vaccine and other encouraging vaccine candidates which
could also help control other expanding mosquito-borne diseases such as chikungunya
and zika virus. The authors conclude that the way forward is for governments and public
health experts to fully commit to addressing dengue with a set of solutions that integrate
vector control methods and vaccination against the virus.
8. Rawson T, Wilkins KE, Bonsall MB. Optimal control approaches for combining
medicines and mosquito control in tackling dengue. R Soc Open Sci. 2020;7(4):181843.
Published 2020 Apr 22. doi:10.1098/rsos.181843
Dengue remains a devastating and debilitating viral infection that is spread by
mosquito vectors, especially Aedes aegypti with more than 4 billion people living at high
risk of the infection. The authors used an epidemiological and integrated vector ecology
strategy to predict effective methods for preventing and controlling dengue and
investigate how vaccination strategies and vector control methods can be best combined
on small networks for dengue disease control and whether the strategies differ under a
different set of circumstances. They show that the most beneficial strategy for reducing
infected individuals is a combination of vaccination and the use of self-limiting
mosquitoes which have been genetically modified. In addition, the authors note that
depending on the impact of human mobility on dengue dynamics, the optimal way to
prevent and control dengue is to focus prevention efforts on centers with large
populations. This is easier when experts utilize mathematical frameworks like optimal
control.
9. Wilder-Smith A, Tissera H, AbuBakar S, et al. Novel tools for the surveillance and
control of dengue: findings by the DengueTools research consortium. Glob Health
Action. 2018;11(1):1549930. doi:10.1080/16549716.2018.1549930
Dengue fever is a major global disease and research shows that climate change is
contributing to its proliferation especially in warmer climates. Research actions to
improve prevention, control, and surveillance along with other measures are highly
relevant. The European Commission provided funding for the DengueTools Consortium
which was tasked to lead a major initiative synthesizing the outputs of this work
conducted between 2011 to 2016. DengueTools modelled its research into three areas,
namely: predictive models for the global spread of dengue, early warning and
surveillance systems, and strategies to prevent dengue in children. The predictive models
focused on case-studies in Sri Lanka, evaluating economic impact, and outbreak
prediction capacity. Early warning addressed preventing dengue transmission in school
children in Thailand using insecticide-treated school uniforms. The final research is
evaluated potential global spread of dengue, and the role of international travel in
transmission. DengueTools made significant advances in strategies for controlling and
preventing dengue transmission in diverse range of settings.
10. Ouédraogo S, Benmarhnia T, Bonnet E, et al. Evaluation of effectiveness of a
community-based intervention for control of dengue virus vector, Ouagadougou, Burkina
Faso. Emerg Infect Dis. 2018;24(10):1859-1867. doi:10.3201/eid2410.180069
The authors evaluated the strengthof a community-based intervention for dengue
prevention and vector in Ouagadougou, the capital of Burkina Faso in West Africa.
Houses in the intervention and control streets were randomly sampled and the outcomes
of the study was obtained before and after the intervention (approximately one year later).
The community-based intervention reduced Ouagadougou residents’ exposure to the
bites of Aedes aegypti with a vector saliva biomarker difference of 0.08. Also, the pupae
index significantly increased in the control population from 218.72 to 255.67 and
decreased in the intervention area from 162.14 to 99.03. The authors also found that
Ouagadougou residents in the intervention population were less likely to associate
malaria with dengue with a risk ratio of 0.70 and they had increased knowledge of the
symptoms of dengue fever with a risk ratio of 1.44. They show in this study that well-
planned, community-based interventions that control exposure to Aedes aegypti are
effective and feasible in large urban areas in West Africa which have limited resources.
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