Pathophysiology of Alzheimer Disease
k.a.
Wk8Assgn2.docxAssignment 2: The Pathophysiology of Disorders
To Complete
Develop a 10- to 15-slide PowerPoint presentation that addresses the following:
Cover Page: Alzheimer’s Disease
· Describe your selected disorder
Slide One: Alzheimer’s Disease
Irreversible, Slowly progressive brain disorder
Destroys memory and thinking skills
Progresses over a course of 5-10 years.
Most Common Cause of Dementia
Accounts for 50% of cases
Ranked Sixth leading cause of death
Notes:
Alzheimer’s disease is an irreversible and slowly progressive brain disorder that destroys memory and thinking skills (Huether & McCance, 2017). The course of the disease progresses over a timeframe of about 5-10 years. Alzheimer’s disease is the most common cause of dementia which accounts for 50% of cases in the United States (Huether & McCance, 2017), and is ranked the sixth leading cause of death (National Institute on Aging, 2019).
· Describe Associated Alterations in Alzheimer’s Disease
Slide Two: Pathophysiology and Associated Alterations in Alzheimer’s Disease
Slide Notes: BELOW IS DIRECTLY FROM HUETHER & McCance textbook.
“Pathologic alterations in the brain include the accumulation of extracellular neuritic plaques containing a core of amyloid beta protein, intraneuronal neurofibrillary tangles, and degeneration of basal forebrain cholinergic neurons with loss of acetylcholine. Failure to process and clear amyloid precursor protein results in the accumulation of toxic fragments of amyloid beta protein that leads to formation of diffuse neuritic plaques, disruption of nerve impulse transmission, and death of neurons. The Tau protein, a microtubule-binding protein, in neurons detaches and forms an insoluble filament called neurofibrillary tangle, contributing to neuronal death. Neuritic plaques and neurofibrillary tangles are more concentrated in the cerebral cortex and hippocampus. The loss of neurons results in brain atrophy with widening of sulci and shrinkage of gyri. Loss of synapses, acetylcholine and other neurotransmitters contributes to the decline of memory and attention and the loss of other cognitive functions associated with alzheimer’s disease (AD).” (Huether & McCance, 2017, p. 371).
Slide Three: Progression of Alzheimer Disease
· Explain changes that occur in at least two body systems
· Explain how genetics, gender, ethnicity, age, and behavior might impact the pathophysiology of the alterations you identified
· Explain how genetics, gender, ethnicity, age, and behavior impact the diagnosis and treatment of Alzheimer’s disease.
· Mind Map- epidemiology, pathophysiology of alterations, risk factors, and clinical presentation, diagnosis, and treatment
REFERENCES TO USE FOR POWERPOINT
Huether, S. E., & McCance, K. L. (2017). Understanding pathophysiology (6th ed.). St. Louis,
MO: Mosby.
Curran, S., & Wattis, J. (2012). Practical management of dementia: A multi-professional approach. Abingdon: Radcliffe Medical.
Murray, F. (2012). Minimizing the risk of Alzheimer's disease.
https://www.alz.org/alzheimers-dementia/what-is-alzheimers
https://www.nia.nih.gov/health/alzheimers-disease-fact-sheet
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