Case Study Analysis

Case Study:

A 65-year-old obese African American male patient presents to his HCP with crampy left lower quadrant pain, constipation, and fevers to 101˚ F. He has had multiple episodes like this one over the past 15 years and they always responded to bowel rest and oral antibiotics. He has refused to have the recommended colonoscopy even with his history of chronic inflammatory bowel disease (diverticulitis), sedentary lifestyle, and diet lacking in fiber. His paternal grandfather died of colon cancer back in the 1950s as well. He finally underwent colonoscopy after his acute diverticulitis resolved. Colonoscopy revealed multiple polyps that were retrieved, and the pathology was positive for adenocarcinoma of the colon.

The Assignment (1- to 2-page case study analysis)

Develop a 1- to 2-page case study analysis in which you: ● Explain why you think the patient presented the symptoms described. ● Identify the genes that may be associated with the development of

the disease. ● Explain the process of immunosuppression and the effect it has on

body systems.

Reading Resources

McCance, K. L. & Huether, S. E. (2019). Pathophysiology: The biologic basis for

disease in adults and children (8th ed.). St. Louis, MO: Mosby/Elsevier.

● Chapter 1: Cellular Biology; Summary Review

● Chapter 2: Altered Cellular and Tissue Biology: Environmental Agents(pp. 46-61;

begin again with Manifestations of Cellular Injury pp. 83-97); Summary Review

● Chapter 3: The Cellular Environment: Fluids and Electrolytes, Acids, and Bases,

● Chapter 4: Genes and Genetic Diseases (stop at Elements of formal genetics);

Summary Review

● Chapter 5: Genes, Environment-Lifestyle, and Common Diseases (stop at

Genetics of common diseases); Summary Review

● Chapter 7: Innate Immunity: Inflammation and Wound Healing

● Chapter 8: Adaptive Immunity (stop at Generation of clonal diversity); Summary

Review

● Chapter 9: Alterations in Immunity and Inflammation (stop at Deficiencies in

immunity); Summary Review

● Chapter 10: Infection (stop at Infectious parasites and protozoans); (start at HIV);

Summary Review

● Chapter 11: Stress and Disease (stop at Stress, illness & coping); Summary

Review

● Chapter 12: Cancer Biology (stop at Resistance to destruction); Summary

Review

● Chapter 13: Cancer Epidemiology (stop at Environmental-Lifestyle factors);

Summary Review

Note: You previously read these chapters in Week 1 and you are encouraged to review

once again for this week.

Justiz-Vaillant, A. A., & Zito, P. M. (2019). Immediate hypersensitivity reactions. In

StatPearls. Treasure Island, FL: StatPearls Publishing. Retrieved from

https://www.ncbi.nlm.nih.gov/books/NBK513315/