I need help here please

Therapeutic Drug Monitoring (TDM) Competency Review

1. What is the purpose of TDM? ……………………………………………………………………………………………………… ……………………………………………………………………………………………………… ……………………………………………………………………………………………………… ……………………………………………………………………………………………………… ……………………………………………………………………………………………………… ……………………………………………………………………………………………………… ……………………………………………………………………………………………………… ………………………………………………………….…………………………………………..

2. For therapeutic drug monitoring to be performed for a drug, what criteria should be met?

……………………………………………………………………………………………………… ……………………………………………………………………………………………………… ……………………………………………………………………………………………………… ……………………………………………………………………………………………………… ……………………………………………………………………………………………………… ………………………………………………………………………………………………………

3. What is the definition of pharmacokinetics? ……………………………………………………………………………………………………… ………………………………………………………… ……………………………………………………………………………………………………… ………………………………………………………… ……………………………………………………………………………………………………… …………………………………………………………

4. In pharmacokinetics, what do the following stand for?

(A) - ………………………………………………………………………………………………

A - ……………………………………………………………………………………………

D - ……………………………………………………………………………………………

M - ………………………………………………………………………………………………

E -…………………………………………………………………………………………………

5. Complete the labels on the following diagram:

6. What do the following stand for?

MEC - …………………………………………………………………………………………

MTC - ……………………………………………………………………………………………

MIC - ………………………………………………………………………………………………

7. What is the definition of pharmacogenomics? ……………………………………………………………………………………………………… ……………………………………………………………………………………………………… ……………………………………………………………………………………………………… ……………………………………………………………………………………………………… ……………………………………………………………………………………………………… ……………………………………………………………………………………………………… ………………………………………………………………………………………………………

8. When should most samples be taken for TDM? ……………………………………………………………………………………………………… ……………………………………………………………………………………………………… ………………………………………………………………………………………………………

9. What sample types can be used for TDM? ……………………………………………………………………………………………………… ……………………………………………………………………………………………………… ……………………………………………………………………………………………………… ……………………………………………………………………………………………………… ……………………………………………………………………………………………………… ……………………………………………………………………………………………………… ……………………………………………………………………………………………………… ………………………………………………………………………………………………………

10.Give two advantages of immunoassay as an analytical technique for TDM?

1. …………………………………………………………………………………………………..

2. …………………………………………………………………………………………………..

11.Give two disadvantages of immunoassay as an analytical technique for TDM?

1. …………………………………………………………………………………………………..

2. ………………………………………………………………………………………………….

12.Give two advantages of chromatography as an analytical technique for TDM?

1. ………………………………………………………………………………………………….

2. ……………………………………………………………………………………………

13.Give two disadvantages of chromatography as an analytical technique for TDM?

1. …………………………………………………………………………………………………..

2. …………………………………………………………………………………………………