TBI discussion post

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TBI.pdf

Traumatic Brain Injury

Traumatic Brain Injury (TBI)

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Epidemiology of TBI

• 1-2 million Americans injured each year

Mechanisms of Injury

Contact forces

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Inertial forces

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Coup and Counter- Coup Injuries

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Blast injury

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Cellular Response to Injury

Focal damage vs. Diffuse injury

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Acute Cellular and Neurochemical Effects of TBI

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Acute Cellular and Neurochemical Effects of TBI

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Acute Cellular and Neurochemical Effects of TBI

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Acute Cellular and Neurochemical Effects of TBI

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General Re-cap:

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Diffuse axonal injury (DAI)

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Tau Pathology and Tangle Formation

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Relationship of neurobiology and neurobehavior

Changes in cognition

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Changes in personality

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Lack of awareness of deficits

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Psychiatric disorders

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