TBI discussion post

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TBI.pdf

Traumatic Brain Injury

Traumatic Brain Injury (TBI)

Epidemiology of TBI

• 1-2 million Americans injured each year

Mechanisms of Injury

Contact forces

Inertial forces

Coup and Counter- Coup Injuries

Blast injury

Cellular Response to Injury

Focal damage vs. Diffuse injury

Acute Cellular and Neurochemical Effects of TBI

Acute Cellular and Neurochemical Effects of TBI

Acute Cellular and Neurochemical Effects of TBI

Acute Cellular and Neurochemical Effects of TBI

General Re-cap:

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Diffuse axonal injury (DAI)

Tau Pathology and Tangle Formation

Relationship of neurobiology and neurobehavior

Changes in cognition

Changes in personality

Lack of awareness of deficits

Psychiatric disorders