Table-3-Asthma-and-COVID-19-2.docx
Table 3. Multivariable analyses of association between asthma and SAR-CoV-2 infection among children aged < 15 year
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Variables
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Model 1:
Unadjusted model
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Model 2:
Adjusted for age and sex
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Model 3:
Adjusted for nationality
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Model 4:
Adjusted for cardiovascular disease and immunocompromised host
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Model 5:
Adjusted for age and sex, cardiovascular disease, immunocompromised host
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Model 6:
Adjusted for all covariates
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RR (95% CI)
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P-value
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RR (95% CI)
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P-value
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RR (95% CI)
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P-value
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RR (95% CI)
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P-value
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RR (95% CI)
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P-value
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RR (95% CI)
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P-value
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Main exposure
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Asthma
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No
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Reference
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Reference
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Reference
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Reference
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Reference
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Reference
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Yes
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1.09 (0.86, 1.39)
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0.460
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1.04 (0.82, 1.32)
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0.755
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1.07 (0.85, 1.37)
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0.556
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1.09 (0.86, 1.38)
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0.485
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1.03 (0.81, 1.31)
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0.783
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1.03 (0.81, 1.31)
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0.801
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Covariates
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Sex
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Female
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Reference
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Reference
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Reference
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Male
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0.98 (0.93, 1.04)
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0.583
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0.98 (0.93, 1.04)
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0.581
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0.98 (0.93, 1.04)
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0.597
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Age (years)
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< 2
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Reference
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Reference
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Reference
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2 - < 6
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1.35 (1.22, 1.51)
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< 0.001
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1.35 (1.22, 1.51)
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< 0.001
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1.31 (1.17, 1.47)
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< 0.001
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6 - < 12
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1.47 (1.33, 1.62)
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< 0.001
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1.46 (1.33, 1.62)
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< 0.001
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1.41 (1.27, 1.56)
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< 0.001
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12 - < 15
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1.47 (1.32, 1.63)
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< 0.001
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1.46 (1.31, 1.63)
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< 0.001
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1.40 (1.25, 1.57)
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< 0.001
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Nationality
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Thai
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Reference
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Reference
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Non-Thai
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0.74 (0.65, 0.83)
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< 0.001
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0.86 (0.76, 0.98)
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0.027
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Cardiovascular diseases
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No
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Reference
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Reference
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Reference
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Yes
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0.68 (0.46, 1.02)
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0.059
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0.72 (0.48, 1.06)
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0.097
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0.72 (0.49, 1.07)
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0.104
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Immunocompromised host*
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No
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Reference
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Reference
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Reference
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Yes
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0.49 (0.18, 1.36)
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0.171
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0.47 (0.17, 1.31)
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0.151
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0.48 (0.18, 1.33)
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0.157
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RR, risk ratio; CI, confidence interval
Multivariable models were estimated by Poisson regression with robust standard error.
* Immunocompromised hosts include people who have at least one of the following malignancies (solid tumor or hematologic malignancy), diseases that are treated by corticosteroid immune suppressants and chemotherapy.