research summary

SAMPLE Summative Table Author, Year,

Study Design,

Class, Rating

Study Purpose

Study Population

Intervention

Outcomes

Conclusions

Limitations

Uberos 2014,

Retrospective cohort study,

Class B,

Rating: + (positive)

To evaluate the effectiveness of vitamin A supplementation for the prevention of prematurity-related complications in VLBW infants

Preterm infants (n=154) born <1500g or <32 weeks’ gestational age

IM vitamin A 5000 IU, three times weekly during the first 28 days of life, compared to no supplementation

No significant difference in BPD incidence, mechanical ventilation, days of CPAP, or mortality between groups

 Risk of sepsis was up to three times higher among the vitamin A group (OR: 3.8, 95% CI: 1.6-8.7)

Universal administration of vitamin A to preterm infants is not justified (due to potential for sepsis risk with no benefit seen in this study), and supplementation should be reserved for ELBW infants with low serum vitamin A levels (<20 μg/dL)

 Sample size

Moreira 2012,

Retrospective cohort study,

Class B,

Rating: ∅ (neutral)

To determine if the continued use of vitamin A supplementation in a NICU is warranted, based on effects of supplementation on BPD incidence.

Preterm infants (n=178) born <1000g

Infants born between July 2004 and December 2005 (n=76) did not receive vitamin A supplementation.

 Infants born between January 2006 and June 2008 (n=102) received three weekly IM vitamin A doses for the first 28 days of life

 Non-significant 11% reduction in BPD incidence with vitamin A supplementation (P = 0.2)

Vitamin A supplementation resulted in a non-significant trend toward reduced BPD incidence in preterm infants, warranting continued use and further trials with larger sample sizes to confirm statistical significance.

 Sample size

 Dose not indicated

Author, Year, Design, Class, Rating*

Study Purpose

Population

Interventions

Results

Conclusions

Strengths/ Limitations

Study 1

Study 2

Study 3

Etc.