Research Paper

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Burdened No Longer: How Continuous Glucose Monitoring is Revolutionary in Diabetes Care

and Why British Columbia Should Fund It

Abstract

This paper discusses what Continuous Glucose Monitoring (CGM) technology is, and

draws on recent scientific research to explain why it is more effective for managing blood

glucose levels and preventing adverse health outcomes in patients with type 1 diabetes than other

methods. It further examines how, despite the health benefits associated with CGM use, the

technology has not yet seen widespread use in Canada due to the high out-of-pocket costs for

patients. Thus, this paper asserts that the British Columbia Ministry of Health should begin

providing public funding for CGM devices to ensure that all type 1 diabetics are able to access

this revolutionary technology and manage their health more effectively.

Figure 1 (left): ​Woman wearing a CGM sensor (Juvenile Diabetes Research Foundation, 2019) Figure 2 (right): ​CGM sensor, insulin pump and smartphone with glucose data (Diabetes Canada, 2018)

Context

Type 1 diabetes is a chronic, autoimmune condition characterized by the body’s inability

to produce insulin. Without insulin, a person’s cells cannot perform the metabolic processes

necessary for life, and so people living with diabetes follow intensive treatment regimens of

injecting insulin and monitoring blood glucose in order to maintain their health. Though the

management of this condition places a significant burden on the patient, recent developments in

technology have begun to provide more effective and less laborious methods of regulating blood

glucose. One of these technologies, Continuous Glucose Monitoring (CGM) has demonstrated

promising benefits for alleviating the medical burdens of type 1 diabetes by reducing the

incidence of extreme hyperglycemia and hypoglycemia (Diabetes Canada, 2018). CGM involves

the insertion of a disposable electrochemical sensor into the skin, which continuously measures

the glucose levels in subcutaneous tissue, and then wirelessly transmits this data to the user’s

insulin pump or smartphone (Vettoretti & Facchinetti, 2019). However, for many people living

with type 1 diabetes in Canada, CGM is a potentially life-saving technology that remains out of

reach due to high costs (Juvenile Diabetes Research Foundation, 2019).

The inaccessibility of CGM technology represents a significant problem, since studies

show that regulation of blood glucose levels using the conventional method of self-monitoring

blood glucose (SMBG), which requires collecting small blood samples from the fingers six to

eight times daily, is demonstrably less effective (Diabetes Canada, 2018). Indeed, as shown in

figure 3, CGM use is associated with lower hemoglobin A1c (HbA1c) levels, which is the

standard metric used to assess a patient’s blood glucose regulation over a three month period

(Senn, Fischli, Slahor, Schelbert, & Henzen, 2019). This is due in part to the fact that the blood

glucose data attained through SMBG only offers information from individual points in time,

whereas CGM allows the patient to make more effective treatment decisions based on 24-hour

data on their blood glucose and its trends. Considering how long-term elevated HbA1c levels can

lead to diabetes-related complications such as kidney failure, neuropathy and amputation, the

importance of utilizing technologies such as CGM to avoid such outcomes becomes evident.

Figure 3​: The impact of CGM use on blood glucose control through trends in HbA1c during a 6-month study (Giani, Snelgrove, Volkening, & Laffel, 2016).

Furthermore, CGM plays a crucial role in the safety of people with type 1 diabetes, as it

provides alerts when blood glucose is too high or too low. This technology can prevent

life-threatening emergencies due to high or low blood glucose by informing the user when there

is a problem and giving them the opportunity to act before serious health problems, such as

seizures, diabetic coma, or ketoacidosis, arise. According to Diabetes Canada, CGM use is

especially effective for type 1 diabetics who experience frequent episodes of hypoglycemia, and

is associated with a decrease in hospitalizations for those who use it (2018).

Finally, a 2019 study seeking to understand the benefits and limitations of CGM use

found that while CGM is generally seen as favourable by type 1 diabetics, one of the primary

reasons for discontinuing the treatment method was the high associated cost (Sørgård, Iversen, &

Mårtensson, 2019). As there is no national funding for CGM in Canada (Graham, 2017), type 1

diabetics without specific private health insurance must pay out-of-pocket for the cost of the

sensors, which ranges from $3000 to $6000 annually (Diabetes Canada, 2018). However, the

study by Sørgård, Iversen, and Mårtensson ascertained through interviews that many of the

diabetics who discontinued their use of CGM would resume using the technology if the cost

barrier were to be eliminated (2019). Thus, it can be concluded that the key to implementing

more widespread use of CGM among type 1 diabetics, and reaping the health benefits it

provides, could be achieved by removing the barrier of cost.

Recommendation

In light of the evidence for how CGM use improves health outcomes, and in accordance

with the recommendations of Diabetes Canada (2018), it is imperative that the British Columbia

Ministry of Health begins providing public funding for the use of CGM by people with type 1

diabetes. All costs associated with CGM should be covered under the province’s health insurance

in order to ensure that every type 1 diabetic in British Columbia can access this potentially

life-saving technology.

Though some may argue that providing this coverage would constitute an increase in

healthcare spending that the province cannot afford, there is evidence to indicate that this policy

would instead be cost-effective. One study tracking the public costs of pregnancy and delivery

for 1441 diabetic women found that the overall costs for the women regulating their glucose

using CGM was lower than for those using SMBG ​(Murphy, Feig, Sanchez, de Portu, & Sale,

2019). As illustrated in Figure 4, although the immediate costs of CGM are higher than SMBG,

this cost is offset by the reduction in length and frequency of neonatal intensive care unit

admissions. Though this data pertains specifically to pregnant women using CGM, the same

principle may be extrapolated to infer that the cost of providing public funding for CGM would

be offset by the consequently reduced medical complications associated with poor blood glucose

regulation.

Figure 4​: Healthcare costs of pregnant women with type 1 diabetes when using CGM compared to SMBG (Murphy, Feig, Sanchez, de Portu, & Sale, 2019).

Another benefit of instituting public funding of CGM would be the opportunity to use it

in conjunction with an insulin pump. CGM sensors now have the ability to communicate with

some insulin pumps in such a way that allows the pump to increase or decrease insulin dosage

based on blood glucose readings (Graham, 2017). While these so-called “closed-loop systems”

or “artificial pancreases” are still an emerging technology, many experts expect them to quickly

become the new standard of care as they are demonstrating even more positive effects on blood

glucose regulation than CGM or insulin pumps alone (Graham, 2017). Thus, if British Columbia

Ministry of Health was to provide CGM funding, it would simultaneously be paving the way for

even more advanced and effective diabetes management technology.

In conclusion, in order to improve care for type 1 diabetics across the province and

reduce healthcare costs associated with poor blood glucose regulation, the British Columbia

Ministry of Health must make CGM accessible through the provision of public funding.

According to an article in the BC Medical Journal, diabetes places a significant burden on the

province’s healthcare system, accounting for over 70% of non-traumatic limb amputations, and

prevalence of both type 1 and type 2 diabetes is expected to continue increasing (Ur, 2018). In

order to ensure that taxpayer money is being spent effectively and that our limited healthcare

resources are not being wasted on preventable hospitalization, it is essential that the province

ensures all diabetics can access the care they need – not just those wealthy enough to afford it.

As long as there remains no cure for type 1 diabetes, those living with the condition rely on the

regulation of blood glucose for their health and survival, and the investment in technologies like

CGM are what allow diabetics to live long, fulfilling lives.

List of Works Cited

Diabetes Canada. (2018). Continuous glucose monitoring [PDF file]. Retrieved from

https://www.diabetes.ca/DiabetesCanadaWebsite/media/Managing-My-Diabetes/Tools

and Resources/Continuous_Glucose_Monitoring_Advocacy_Pkg_4.pdf?ext=.pdf.

Giani, E., Snelgrove, R., Volkening, L. K., & Laffel, L. M. (2016). Continuous glucose

monitoring (CGM) adherence in youth with type 1 diabetes: Associations with

biomedical and psychosocial variables. Journal of Diabetes Science and Technology,

11(3), 476–483. doi: 10.1177/1932296816676280

Graham, C. (2017). Continuous glucose monitoring and global reimbursement: An update.

Diabetes Technology & Therapeutics​, ​19​(S3). doi: 10.1089/dia.2017.0096

Juvenile Diabetes Research Foundation. (2019). Making continuous glucose monitoring

accessible to all. Retrieved from

https://www.jdrf.ca/blog/making-continuous-glucose-monitoring-accessible-to-all/.

Murphy, H. R., Feig, D. S., Sanchez, J. J., de Portu, S., & Sale, A. (2019). Modelling potential

cost savings from use of real-time continuous glucose monitoring in pregnant women

with Type 1 diabetes. ​Diabetic Medicine​, ​36​(12), 1652–1658. Retrieved from

https://www.ncbi.nlm.nih.gov/pubmed/31162713

Nicolucci, A., Rossi, M., Dostilio, D., Delbaere, A., Portu, S. D., & Roze, S. (2018).

Cost-effectiveness of sensor-augmented pump therapy in two different patient

populations with type 1 diabetes in Italy. ​Nutrition, Metabolism and Cardiovascular

Diseases​, ​28​(7), 707–715. doi: 10.1016/j.numecd.2018.03.011

Senn, J.-D., Fischli, S., Slahor, L., Schelbert, S., & Henzen, C. (2019). Long-term effects of

initiating continuous subcutaneous insulin infusion (CSII) and continuous glucose

monitoring (CGM) in people with type 1 diabetes and unsatisfactory diabetes control.

Journal of Clinical Medicine​, ​8​(3), 394. doi: 10.3390/jcm8030394

Sørgård, B., Iversen, M., & Mårtensson, J. (2019). Continuous glucose monitoring in adults with

type 1 diabetes: A balance between benefits and barriers: A critical incident study.

Journal of Clinical Nursing​. Retrieved from

https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocn.14911?referrer_access_token=q1k

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Ur, E. (2018). Diabetes in British Columbia: Starvation in the midst of plenty. ​BC Medical

Journal​, ​60​(9), 436–438. Retrieved from

https://www.bcmj.org/editorials/guest-editorial-diabetes-british-columbia-starvation-mids

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Vettoretti, M., & Facchinetti, A. (2019). Combining continuous glucose monitoring and insulin

pumps to automatically tune the basal insulin infusion in diabetes therapy: a review.

BioMedical Engineering OnLine​, ​18​(1). doi: 10.1186/s12938-019-0658-x