Assigment .Apa seven . All instructions attached.

1

SafeAssign Originality Report • Submitted on Sun, Jan 28, 2024, 6:19 PM

Week 3 Medication Paper Psychopharmacology for Advanced Practice Nursing-HFX-DL01 Tashara R Jean

Total Score: 47 % High riskYoshira Chu Submission UUID: bd1c83d7-ef78-bc67-195b-a4e0b7653f0f

Total Number of Reports

1 Highest Match

47 % Medicationpaper.docx

Average Match

47 % Submitted on

01/28/24 06:19 PM EST

Average Word Count

1,338 Highest: Medicationpaper.docx

47 %Additional content Word Count: 1,338 Source: Medicationpaper.docx

18 %Institutional database (5)

Student paper Student paper Student paper

Student paper Student paper

17 %Global database (3)

Student paper Student paper Student paper

12 %Internet (2)

wikipedia cincinnatichildrens

Top sources (3)

5 1 7

2 6

9 10 4

3 8

9 Student paper 9 % 3 wikipedia 8 % 10 Student paper 6 %

SERTRALINE 1

Medication: Sertraline (Zoloft)

Yoshira Chu

Florida National University

Psychopharmacology for Advanced Practice Nursing-DFX-DL01

Dr. Tashara R Jean

January 20, 2024

Medication: Sertraline (Zoloft) A selective serotonin reuptake inhibitor (SSRI), Zoloft is a class of antidepressants (Huddart et al., 2020). One way it helps with

depression treatment is by keeping serotonin levels in the brain and nerves balanced. Sertraline, sold as Zoloft, is an SSRI antidepressant. Sertraline, an FDA-

approved medicine, helps control mood and anxiety disorders by maintaining brain and nerve serotonin levels. It examines practical uses, non-approved uses, side effects, mechanism of action, lab monitoring, and the vital role of Psychiatric Mental Health Nurse Practitioners (PMHNPs) in sertraline therapy supervision (Huddart et al., 2020). Evidence-Based Treatment Selection (FDA-Approved Uses) Sertraline is categorized as a selective serotonin reuptake inhibitor (SSRI).

The FDA has approved it for the treatment of major depressive disorder (MDD), obsessive-compulsive disorder (OCD), panic disorder, post-traumatic stress disorder (PTSD), social anxiety disorder, and premenstrual dysphoric disorder (PMDD) (Kolitsopoulos et al., 2021). All of the mental health illnesses described are psychiatric disorders, including MDD, OCD, Panic Disorder, SAD, and PTSD. These conditions involve problems controlling emotions, cognition, actions, or emotional state (Kolitsopoulos et al., 2021). These mental health disorders have different symptoms and diagnostic criteria, but they all result from the complex interaction between biology, psychology, and the environment. These illnesses can vary in severity and cause a variety of symptoms. Off-Label Uses

1

2

2

3

1

3

1

2

Alternative uses for Sertraline may be suggested from time to time by healthcare providers. This drug use is classified as off-label since the FDA has not approved it. Beyond its basic uses, Sertraline has been discovered to have additional applications. Some of these conditions include eating disorders such as bulimia nervosa, generalized anxiety disorder, premature ejaculation, and body dysmorphic disorder (Morris et al., 2021). Contraindications

If you're sensitive to Sertraline, on monoamine oxidase inhibitors (MAOIs), or worried about serotonin syndrome, don't take it. Seizure, hepatic impairment, and bipolar illness patients should be treated cautiously because manic episodes may occur (Morris et al., 2021). Do not use Sertraline if you are allergic to it or

its constituents. Taking Sertraline with thioridazine, pimozide, or MAOIs like linezolid or methylene blue is risky. Informing patients about Sertraline's negative effects with other serotonergic medications is vital. The alcohol concentration of the Sertraline solution may interact with disulfiram. Thus, they should not be used together. Sertraline should not be started within two weeks following monoamine oxidase medication discontinuation to avoid serotonin syndrome effects (Poweleit et al., 2019). This product is advised against for children and young adults in the US. When treating 18–24-year-olds, self-harm thoughts may grow.

Mechanism of Action

By decreasing brain serotonin reuptake, Sertraline raises synaptic serotonin levels. Some feel this action's neurotransmission enhancement helps mood and anxiety disorders (Poweleit et al., 2019). The antidepressant sertraline is an SSRI. An antidepressant that blocks brain serotonin reuptake is Sertraline.

Serotonin buildup develops when reuptake is blocked. Sleepiness, mood, and personality depend on serotonin. Blocking serotonin reuptake helps cure major depression. According to research, Sertraline has a stronger dopaminergic impact than other SSRIs and has less effect on norepinephrine and dopamine absorption (Huddart et al., 2020). Due to its mechanism of action, Sertraline helps cure several mental diseases. Potential Side Effects

Sertraline can cause nausea, diarrhea, insomnia, vertigo, and erectile dysfunction. Serotonin syndrome, allergies, and self-harm (particularly in younger people) are major adverse effects that require medical care. Compared to monoamine oxidase inhibitors and tricyclic antidepressants, newer SSRIs are frequently better tolerated (Kolitsopoulos et al., 2021). Sertraline often causes seizures, vertigo, nausea, vomiting, diarrhea, excessive perspiration, dry mouth, disorientation, hallucinations, shaking, lethargy, sexual dysfunction, tiredness, runny nose, and female sexual dysfunction. Because it reduces platelet aggregation, Sertraline might cause bleeding. Sertraline modifies the QT interval slightly, but the effect is dose-dependent and modest. Citalopram is riskier than sertraline and other SSRIs. Sertraline may cause serotonin syndrome when combined with other serotonin-modifying drugs. Symptoms include hyperthermia, agitated delirium, myoclonus, muscle rigidity, diaphoresis, tremor, and hyperreflexia (Morris et al., 2021). Depressed people in their 20s and 30s taking Sertraline or other antidepressants may consider or attempt suicide. Sertraline should be used cautiously in seniors. Its tendency to cause hyponatremia or an inappropriate antidiuretic hormone syndrome makes it a high-risk medicine for geriatric individuals under the Beers Criteria. Infants born to moms who take Sertraline in the first trimester are more likely to have atrial and ventricular septal abnormalities (Poweleit et al., 2019). Sertraline in the third trimester or later increases the chance of hospitalization, feeding tubes, and breathing devices for babies. Lab Monitoring/Follow-Up

Sertraline rarely requires laboratory monitoring (Poweleit et al., 2019). Regular follow-up consultations are needed to check therapy efficacy, potential side effects, and dosage adjustments. Sometimes liver and kidney function must be monitored. Watch for changes in behavior, anxiety, suicidal thoughts, or other signs of the patient's condition deteriorating. Adjusting sertraline dosage requires regular depression and suicidality assessments. While taking Sertraline, bipolar illness patients may experience mania. Sertraline users should be regularly monitored for manic episodes, especially if they have a family history of bipolar disorder or mania (Morris et al., 2021). Monitor patients on Sertraline for irregular bleeding, adverse effects, and withdrawal symptoms if the medicine is stopped abruptly. Sertraline is often taken with aspirin, NSAIDs, warfarin, or other anticoagulants to reduce bleeding risk due to its platelet aggregation effects. Since senior individuals are more prone to SIADH and hyponatremia, salt concentration and mental state must be monitored periodically (Kolitsopoulos et al., 2021). Sertraline may be unsafe for those with myocardial infarction, heart failure, or other cardiac disorders. The modest impact of QT prolongation suggests that ECG QT monitoring may benefit healthcare providers. Pregnant and breastfeeding women can safely take Sertraline. Therapeutic drug monitoring is not required, but it is recommended to protect pregnant women and their unborn children from drug dangers. In the third trimester, a woman using Sertraline should discuss the risks and benefits with her doctor (Huddart et al., 2020). They will then decide whether to adjust the dosage. Role of the Psychiatric Mental Health Nurse

Practitioner (PMHNP) Sertraline prescribing and oversight are critical to the PMHNP. Working with other healthcare experts, educating patients about Sertraline, monitoring for adverse effects, and doing a thorough mental examination to establish eligibility are all part of this job (Morris et al., 2021). The PMHNP must closely monitor the patient's reaction to treatment and adjust dosage or pharmaceutical alternatives. A PMHNP helps patients and their family understand their condition, ease their fears, and follow their drug regimen. Conclusion

The FDA has authorized Sertraline, a long-standing antidepressant. It treats significant depression, OCD, panic attacks, PTSD, social anxiety, and PMDD. Before widespread use, limits and negative effects must be examined. To maximize sertraline safety and efficacy in mental health treatment, PMHNPs must prescribe, monitor, and educate patients (Poweleit et al., 2019). Sertraline with care must be integrated into comprehensive mood and anxiety disorder treatment programs as psychopharmacology becomes more complex.

References

Huddart, R., Hicks, J. K., Ramsey, L. B., Strawn, J. R., Smith, D. M., Babilonia, M. B.,... & Klein, T. E. (2020). PharmGKB summary: sertraline pathway,

pharmacokinetics. Pharmacogenetics and genomics, 30(2), 26. Kolitsopoulos, F., Ramaker, S., Compton, S., Broderick, S., Orazem, J., Bao, W.,... &

Chappell, P. (2021). Sertraline Pediatric Registry for the Evaluation of Safety: Design and clinical characteristics of pediatric patients prescribed sertraline.

Journal of Child and Adolescent Psychopharmacology, 31(6), 411-420. Morris, M. R., Hoeflich, C. C., Nutley, S., Ellingrod, V. L., Riba, M. B., & Striley, C. W.

(2021). Use of psychiatric medication by college students: A decade of data. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy,

41(4), 350-358. Poweleit, E. A., Aldrich, S. L., Martin, L. J., Hahn, D., Strawn, J. R., & Ramsey, L. B. (2019). Pharmacogenetics of sertraline tolerability and

response in pediatric anxiety and depressive disorders. Journal of child and adolescent psychopharmacology, 29(5), 348-361.

4

1

5

1

1

6

7 8

7 9

9

10

10 10

5 8

5

3

Source Matches (25)

Student paper 100 %

Student paper 100 %

Student paper 100 %

https://en.wikipedia.org/wiki?curid=149612 64 %

Student paper 77 %

https://en.wikipedia.org/wiki?curid=149612 75 %

Student paper 100 %

Student paper 66 %

1

Submitted paper

Florida National University

Original source

FLORIDA NATIONAL UNIVERSITY

2

Submitted paper

Psychopharmacology for Advanced Practice Nursing-DFX-DL01

Original source

Psychopharmacology for Advanced Practice Nursing-DFX-DL01

2

Submitted paper

Tashara R Jean January 20, 2024

Original source

Tashara R Jean January 20, 2024

3

Submitted paper

Sertraline (Zoloft) A selective serotonin reuptake inhibitor (SSRI), Zoloft is a class of antidepressants (Huddart et al., 2020).

Original source

Sertraline is a selective serotonin reuptake inhibitor (SSRI)

1

Submitted paper

Sertraline, sold as Zoloft, is an SSRI antidepressant.

Original source

Sertraline (Zoloft) as an Antidepressant

3

Submitted paper

Evidence-Based Treatment Selection (FDA-Approved Uses) Sertraline is categorized as a selective serotonin reuptake inhibitor (SSRI). The FDA has approved it for the treatment of major depressive disorder (MDD), obsessive-compulsive disorder (OCD), panic disorder, post-traumatic stress disorder (PTSD), social anxiety disorder, and premenstrual dysphoric disorder (PMDD) (Kolitsopoulos et al., 2021).

Original source

Sertraline is a selective serotonin reuptake inhibitor (SSRI) Sertraline has been approved for major depressive disorder (MDD), obsessive–compulsive disorder (OCD), post-traumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), panic disorder, and social anxiety disorder (SAD)

1

Submitted paper

Off-Label Uses

Original source

Off-Label Uses

4

Submitted paper

Do not use Sertraline if you are allergic to it or its constituents.

Original source

Precautions of Use Do not use sertraline if you are allergic to it, or if you also take pimozide

4

Student paper 100 %

Student paper 72 %

Student paper 100 %

Student paper 100 %

Student paper 74 %

Student paper 100 %

Student paper 100 %

https://www.cincinnatichildrens.org/research/divisions/r/rips/labs/ramsey 100 %

Student paper 100 %

Student paper 100 %

1

Submitted paper

Mechanism of Action

Original source

Mechanism of action

5

Submitted paper

The antidepressant sertraline is an SSRI.

Original source

Sertraline as an Antidepressant

1

Submitted paper

Potential Side Effects

Original source

Potential Side Effects

1

Submitted paper

Lab Monitoring/Follow-Up

Original source

Lab Monitoring/Follow-Up

6

Submitted paper

Role of the Psychiatric Mental Health Nurse Practitioner (PMHNP) Sertraline prescribing and oversight are critical to the PMHNP.

Original source

The Psychiatric Mental Health Nurse Practitioner (PMHNP) role is integral in prescribing and managing Sertraline

7

Submitted paper

Huddart, R., Hicks, J. K., Ramsey, L. B., Strawn, J. R., Smith, D.

Original source

Huddart, R., Hicks, J K., Ramsey, L B., Strawn, J R., Smith, D

7

Submitted paper

M., Babilonia, M.

Original source

M., Babilonia, M

8

Submitted paper

sertraline pathway, pharmacokinetics.

Original source

Sertraline pathway, pharmacokinetics

7

Submitted paper

Pharmacogenetics and genomics, 30(2), 26.

Original source

Pharmacogenetics and genomics, 30(2), 26

9

Submitted paper

Kolitsopoulos, F., Ramaker, S., Compton, S., Broderick, S., Orazem, J., Bao, W.,...

Original source

Kolitsopoulos, F., Ramaker, S., Compton, S., Broderick, S., Orazem, J., Bao, W.,

5

Student paper 100 %

Student paper 100 %

Student paper 100 %

Student paper 100 %

Student paper 100 %

https://www.cincinnatichildrens.org/research/divisions/r/rips/labs/ramsey 100 %

Student paper 100 %

9

Submitted paper

Sertraline Pediatric Registry for the Evaluation of Safety: Design and clinical characteristics of pediatric patients prescribed sertraline. Journal of Child and Adolescent Psychopharmacology, 31(6), 411-420.

Original source

Sertraline Pediatric Registry for the Evaluation of Safety Design and Clinical Characteristics of Pediatric Patients Prescribed Sertraline Journal of Child and Adolescent Psychopharmacology, 31(6), 411-420

10

Submitted paper

R., Hoeflich, C. C., Nutley, S., Ellingrod, V. L., Riba, M. B., & Striley, C.

Original source

R., Hoeflich, C C., Nutley, S., Ellingrod, V L., Riba, M B., & Striley, C

10

Submitted paper

Use of psychiatric medication by college students: A decade of data.

Original source

Use of psychiatric medication by college students A decade of data

10

Submitted paper

The Journal of Human Pharmacology and Drug Therapy, 41(4), 350-358.

Original source

The Journal of Human Pharmacology and Drug Therapy, 41(4), 350-358

5

Submitted paper

A., Aldrich, S. L., Martin, L. J., Hahn, D., Strawn, J. R., & Ramsey, L.

Original source

A., Aldrich, S L., Martin, L J., Hahn, D., Strawn, J R., & Ramsey, L

8

Submitted paper

Pharmacogenetics of sertraline tolerability and response in pediatric anxiety and depressive disorders.

Original source

Pharmacogenetics of Sertraline Tolerability and Response in Pediatric Anxiety and Depressive Disorders

5

Submitted paper

Journal of child and adolescent psychopharmacology, 29(5), 348-361.

Original source

Journal of child and adolescent psychopharmacology, 29(5), 348-361