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SafeAssign Originality Report • Submitted on Sun, Jan 28, 2024, 5:19 PM
Week 3 Medication Paper Psychopharmacology for Advanced Practice Nursing-HFX-DL01 Tashara R Jean
Total Score: 43 % High riskDeysi Rill Aguirre Submission UUID: 58a60cb5-51d5-6dfc-c272-d654e819279b
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43 % ComprehensiveOverviewofSertraline.…
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Comprehensive Overview of Sertraline
Deysi Rill Aguirre
Florida National University
Psychopharmacology for Advanced Practice Nursing-DFX-DL01
Dr. Tashara R Jean
January 20, 2024
Comprehensive Overview of Sertraline
Sertraline is one of the most important drugs used in treating a number of psychological disorders. This paper will delve into the many details of Sertraline. We will discuss what the FDA claims is beneficial, other uses for it, when to avoid using it, how the medication works and also how a mental health nurse practitioner (PMHNP) can assist patients in its use. Evidence-Based Therapy Option
The FDA approves Sertraline for the treatment of major depressive disorder, PTSD, panic attacks and also social anxiety (Lewis et al., 2019; Hantsoo et al., 2021;
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Kassis, 2020). It was revealed in one study that Sertraline is more effective and tolerable than a placebo for the major depression management (Lewis et al., 2020). Off-Label Uses
Sertraline is an off-label treatment that incorporates a variety of the psychiatric disorders. In this sense it is particularly very effective in the management of GAD, and producing significant symptom reduction and improvement of functioning. The use of sertraline has been found to be very effective in managing the eating disorder such as bulimia nervosa and also binge eating disorder because it decreases the incidence of binge-eating episodes and purging behaviors (Fornaro et al., 2023). One of the other interesting non-directed uses is in the premature ejaculation therapy where sertraline has shown a considerable improvement (Yi et al., 2019). Other off-label uses are based on the clinical experience and also research that provide much evidence of polymorphism as a psychotropic drug for sertraline. Contraindications
Since sertraline is very well-tolerated, it also has some contraindications. It is not recommended for those who are allergic to the sertraline or its components. One of the primary factors is the possibility of serotonin syndrome, a life-threatening condition, when sertraline is combined with other serotonergic agents, such as the MAOIs. Therefore, when transitioning from MAOIs to the sertraline, a washout period is really necessary (Scotton et al., 2019). Sertraline is also prescribed with caution in the patients with a history of seizures because it may lower the seizure threshold. Moreover, sertraline may cause mania or rapid cycling in the bipolar disorder patients and the close monitoring is necessary in this group of patients. Mechanism of Action
Sertraline works by blocking the reabsorption of the serotonin in the brain. Sertraline inhibits the reuptake transporter and thus increases the amount of serotonin in the synaptic cleft, making the serotonergic neurotransmission much stronger. The increase in serotonin is connected to the better mood and the decreased anxiety, which is the basis of sertraline’s ability to treat depression and anxiety-related conditions. Its selectivity for the serotonin transporter over the other neurotransmitter transporters is very critical to its side effect profile, which is typically more favorable than that of the older antidepressants (Huddart et al., 2020). Potential Side Effects
The adverse effect profile of sertraline consists of the gastrointestinal disturbances like nausea and also diarrhea, insomnia, sexual dysfunction, and dry mouth. Most of these side effects are very mild to moderate and also temporary, but they may still affect the medication adherence. One major issue is the possibility of increased suicidal thoughts, especially among the children, teenagers, and also young adults. Thus, close monitoring during the first stage of the treatment is very crucial. Serotonin syndrome, however, although very rare, is a very serious side effect requiring immediate medical treatment (Anagha et al., 2021). Lab
Monitoring/Follow Up
The monitoring of the sertraline patients is very essential to ensure the safety and also the efficacy of the treatment. Primary follow-up is usually done in 2-4 weeks after the start of the treatment to evaluate the efficacy and tolerability. After the initial follow-up, the subsequent follow-ups should take place at regular intervals to check for any late side effects. For those with underlying conditions, such as liver damage or also cardiac problems, closer monitoring may be necessary. One of the most important aspects of the follow-up care is the regular assessment of mental status, especially when it comes to the suicidal ideation. In addition, liver enzyme monitoring, electrolyte levels and also cardiac function (in those with pre-existing cardiac conditions) are recommended (Anagha et al., 2021). Role of the Psychiatric Mental Health Nurse Practitioner
The PMHNP has a very important role in managing the sertraline treatment. The role of the PMHNP starts with a complete assessment of the patient which includes psychiatric, medical and also the drug history. This broad assessment is particularly critical in establishing whether the sertraline is appropriate for all the patients. When sertraline is prescribed, the PMHNP becomes the hub of the patient education. It is extremely important to tell the patient how the medication should work, what it can do and also why taking the medication as directed is so critical. This educational component is an extremely very valuable element that promotes the realistic attitudes and also increases the degree of medication compliance. The other crucial element in the role of the PMHNP is the monitoring and follow-up. They are also in charge of monitoring the patient’s response to the administered drug, as well as they dealing with any side effects and dosage changes when required. This also includes the tracking of any indication of developing a suicidal tendency, particularly among the young population, as well as a reaction to the treatment. The PMHNP also organizes the care with many other health providers to ensure that the patient gets comprehensive mental treatment. This can include working with numerous psychotherapists, primary care doctors and also other professionals to ensure an efficient treatment. Conclusion
The evolution of antidepressant therapy is personified by the Sertraline which has a broad field of application in the psychiatric disorders. Its effectiveness, together with a moderately acceptable side effect profile makes it a very attractive choice in the management of the affective and also anxiety disorders. PMHNPs play a crucial role in this process as they combine not only prescription but also patient education, close monitoring and coordinated whole-person care. The research and clinical practice will continue to build up our knowledge on the capacities of the sertraline including the off- label uses.
References
Anagha, K., Shihabudheen, P., & Uvais, N. A. (2021). Side effect profiles of selective serotonin reuptake inhibitors: a cross-sectional study in a naturalistic
setting. The Primary Care Companion for CNS Disorders, 23(4), 35561. Fornaro, M., Mondin, A. M., Billeci, M., Fusco, A., De Prisco, M., Caizza, C.,... & de Bartolomeis, A. (2023). Psychopharmacology of eating disorders: Systematic review and meta-analysis of randomized controlled trials. Journal of
Affective Disorders. Hantsoo, L., Grillon, C., Sammel, M., Johnson, R., Marks, J., & Epperson, C. N. (2021). Response to sertraline is associated with
reduction in anxiety-potentiated startle in premenstrual dysphoric disorder. Psychopharmacology, 238, 2985-2997. Huddart, R., Hicks, J. K., Ramsey, L. B.,
Strawn, J. R., Smith, D. M., Babilonia, M. B.,... & Klein, T. E. (2020). PharmGKB summary: sertraline pathway, pharmacokinetics. Pharmacogenetics and
genomics, 30(2), 26. Kassis, K. N. (2020). Is Sertraline Effective At Reducing The Symptoms Of Anxiety In Those Diagnosed With Generalized Anxiety Disorder
(GAD)?. Lewis, G., Duffy, L., Ades, A., Amos, R., Araya, R., Brabyn, S.,... & Lewis, G. (2019). The clinical effectiveness of sertraline in primary care and the
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Scotton, W. J., Hill, L. J., Williams, A. C., & Barnes, N. M. (2019). Serotonin syndrome: pathophysiology, clinical features, management, and potential
future directions. International Journal of Tryptophan Research, 12, 1178646919873925. Yi, Z. M., Chen, S. D., Tang, Q. Y., Tang, H. L., & Zhai, S. D. (2019).
Efficacy and safety of sertraline for the treatment of premature ejaculation: systematic review and meta-analysis. Medicine, 98(23).
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Submitted paper
Florida National University Psychopharmacology for Advanced Practice Nursing-DFX-DL01
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Florida National University Psychopharmacology for Advanced Practice Nursing-DFX-DL01
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Off-Label Uses
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Off-Label Uses
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Mechanism of Action
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Mechanism of Action
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Potential Side Effects
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Potential Side Effects
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Lab Monitoring/Follow Up
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Lab Monitoring/ Follow up
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Role of the Psychiatric Mental Health Nurse Practitioner
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Role of the Psychiatric Mental Health Nurse Practitioner
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Side effect profiles of selective serotonin reuptake inhibitors:
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Selective serotonin reuptake inhibitors
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Systematic review and meta-analysis of randomized controlled trials.
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systematic review and meta-analysis of randomized controlled trials
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https://www.statpearls.com/sp/md/487/28926/ 100 %
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https://scitechdaily.com/ssri-antidepressants-zoloft-sertraline-may-reduce-anxiety-more-than-depressive-symptoms/ 100 %
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Journal of Affective Disorders.
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Journal of affective disorders
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Hantsoo, L., Grillon, C., Sammel, M., Johnson, R., Marks, J., & Epperson, C.
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Hantsoo, L., Grillon, C., Sammel, M., Johnson, R., Marks, J., & Epperson, C
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Response to sertraline is associated with reduction in anxiety-potentiated startle in premenstrual dysphoric disorder. Psychopharmacology, 238, 2985-2997.
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Response to sertraline is associated with reduction in anxiety-potentiated startle in premenstrual dysphoric disorder Psychopharmacology, 238(10), 2985–2997
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Huddart, R., Hicks, J. K., Ramsey, L. B., Strawn, J. R., Smith, D.
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Huddart, R., Hicks, J K., Ramsey, L B., Strawn, J R., Smith, D
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M., Babilonia, M.
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M., Babilonia, M
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sertraline pathway, pharmacokinetics. Pharmacogenetics and genomics, 30(2), 26.
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sertraline pathway, pharmacokinetics Pharmacogenetics and genomics, 30(2), 26
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Is Sertraline Effective At Reducing The Symptoms Of Anxiety In Those Diagnosed With Generalized Anxiety Disorder (GAD)?.
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Is Sertraline Effective At Reducing The Symptoms Of Anxiety In Those Diagnosed With Generalized Anxiety Disorder (GAD)
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Lewis, G., Duffy, L., Ades, A., Amos, R., Araya, R., Brabyn, S.,...
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Lewis, G., Duffy, L., Ades, A., Amos, R., Araya, R., Brabyn, S.,
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The clinical effectiveness of sertraline in primary care and the role of depression severity and duration (PANDA):
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“The clinical effectiveness of sertraline in primary care and the role of depression severity and duration (PANDA)
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https://www.pdr.net/drug-summary/Zoloft-sertraline-hydrochloride-474.3608 66 %
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a pragmatic, double-blind, placebo-controlled randomised trial. The Lancet Psychiatry, 6(11), 903-914.
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a pragmatic, double-blind, placebo-controlled randomised trial The Lancet Psychiatry, 6(11), 903-914
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J., Hill, L. J., Williams, A. C., & Barnes, N.
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J., Hill, L J., Williams, A C., & Barnes, N
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pathophysiology, clinical features, management, and potential future directions.
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Pathophysiology, clinical features, management, and potential future directions
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International Journal of Tryptophan Research, 12, 1178646919873925.
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International Journal of Tryptophan Research, 12, 1178646919873925
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Efficacy and safety of sertraline for the treatment of premature ejaculation:
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For the treatment of premature ejaculation†
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systematic review and meta-analysis.
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systematic review and meta-analysis
