Unit V Literature Review

Research Conducted at Colorado State University Has Updated Our Knowledge about Cancer Risk (Inherent aerobic capacity-dependent differences in breast carcinogenesis)

Obesity, Fitness & Wellness Week . (Oct. 7, 2017): p3813.

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2017 OCT 7 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators discuss new findings in Oncology - Cancer Risk. According to news reporting originating from Fort Collins, Colorado, by NewsRx correspondents, research stated, "Although regular physical activity is associated with improvement in aerobic capacity and lower breast cancer risk, there are heritable sets of traits that affect improvement in aerobic capacity in response to physical activity. Although aerobic capacity segregates risk for a number of chronic diseases, the effect of the heritable component on cancer risk has not been evaluated."

Our news editors obtained a quote from the research from Colorado State University, "Therefore, we investigated breast carcinogenesis in rodent models of heritable fitness in the absence of induced physical activity. Female offspring of N:NIH rats selectively bred for low (LIAC) or high (HIAC) inherent aerobic capacity were injected intraperitoneally with 1-methyl-1-nitrosurea (70 mg/kg body wt). At study termination 33 weeks post-carcinogen, cancer incidence (14.0 versus 47.3%; p<0.001) and multiplicity (0.18 versus 0.85 cancers per rat; p<0.0001) were significantly decreased in HIAC versus LIAC rats, respectively. HIAC had smaller visceral and subcutaneous body fat depots than LIAC and activity of two proteins that regulated the mammalian target of rapamycin, protein kinase B (Akt), and adenosine monophosphate-activated protein kinase were suppressed and activated, respectively, in HIAC."

According to the news editors, the research concluded: "Although many factors distinguish between HIAC and LIAC, it appears that the protective effect of HIAC against breast carcinogenesis is mediated, at least in part, via alterations in core metabolic signaling pathways deregulated in the majority of human breast cancers."

For more information on this research see: Inherent aerobic capacity-dependent differences in breast carcinogenesis. Carcinogenesis, 2017;38(9):920-928. (Oxford University Press - www.oup.com/; Carcinogenesis - carcin.oxfordjournals.org)

The news editors report that additional information may be obtained by contacting H.J. Thompson, Cancer Prevention Laboratory, Colorado State University, Fort Collins, CO 80523-1173, United States. Additional authors for this research include L.W. Jones, L.G. Koch, S.L. Britton, E.S. Neil and J.N McGinley.

Keywords for this news article include: Kinase, Colorado, Oncology, Cancer Risk, Fort Collins, United States, Breast Cancer, Carcinogenesis, Risk and Prevention, Enzymes and Coenzymes, Breast Ductal Carcinoma, North and Central America.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2017, NewsRx LLC

The citation for this news report is: NewsRx. Research Conducted at Colorado State University Has Updated Our Knowledge about Cancer Risk (Inherent aerobic capacity-dependent differences in breast carcinogenesis). Obesity, Fitness & Wellness Week. October 7, 2017; p 3813.

Source Citation   (MLA 8th Edition)

"Research Conducted at Colorado State University Has Updated Our Knowledge about Cancer Risk (Inherent aerobic capacity-dependent differences in breast carcinogenesis)." Obesity, Fitness & Wellness Week, 7 Oct. 2017, p. 3813. Health Reference Center Academic, http://link.galegroup.com/apps/doc/A507518723/HRCA?u=oran95108&sid=HRCA&xid=5c19cc2c. Accessed 9 Dec. 2017.