Need corrections and improvements for final research- Composition
Franco 1
Attention Deficit Hyperactivity Disorder (ADHD) is considered one of the most
recognized, and commonly treated psychiatric disorders in the world. Individuals with ADHD
frequently possess unfortunate damage in learning, communicating, and personal relationship
behavior. Polanczyc explains that Attention-Deficit/Hyperactivity Disorder (ADHD) is a
common, long-lasting, treatable childhood psychiatric disorder, characterized by a pattern of
developmentally inappropriate inattention, motor restlessness and impulsivity that affects
approximately 3 – 7% of school-aged children (qtd. in Curatolo et al. 79). ADHD is also
connected with many unhealthy illnesses and impairments similar to bipolar disorder,
depression, and learning disabilities. Many ADHD studies have discovered potentially helpful
treatments for patients; yet, no studies have ever accurately established what causes ADHD in
patients. According to Still, “ADHD was first recognized 100 years ago as a childhood disorder
found mainly in boys, and was initially described as ‘hyperactivity’ or ‘hyperkinetic’ disorder of
childhood” (qtd. in Curatolo et al. 79). However, the medical definition for ADHD has
encountered a few beneficial adjustments throughout the years. These changes have allowed
adolescents, and adults with ADHD to be treated as well; consequently, the amount people being
diagnosed with ADHD every year has increased tremendously. Rawson and Condon share that
the steep increase in the diagnosis of ADHD during the 1990s in the United States led to a
parallel increase in production and societal exposure to legally distributed amphetamine (qtd. in
Berman 123). Generally, patients who are diagnosed with ADHD begin with stimulant treatment
for a more efficacious outcome. Solento states, “ADHD stimulant medications are believed to
exert their therapeutic effects by increasing the amount of dopamine and noradrenaline
(norepinephrine) available in the neuronal system (qtd. in Froehlich et al. 99). Some of these
stimulants include; amphetamine, dextroamphetamine (Adderall), methylphenidate (Ritalin), and
Franco 2
methamphetamine (Desoxyn). Stimulants used in ADHD treatment are surely capable of
providing patients with positive results; still, the detrimental effects caused by stimulants
definitely outweigh any benefits they may offer.
Stimulant treatment for Attention Deficit Hyperactivity Disorder has become extremely
controversial due to its adverse side effects; however, its positive effects have caused patients to
continuously favor this form of treatment. Stimulants could potentially be the most beneficial
form of treatment if, of course, patients are diagnosed adequately. Jensen states, “In the United
States and increasingly in Europe, phsychostimulants are first-line treatments for this disorder”
(qtd. in Singh 957). Psychostimulants have gradually become the most commonly preferred
drugs in the treatment of ADHD because they have shown to be helpful, and productive in the
lives of patients with ADHD. Kahbazi et al. make known that research has shown that stimulant
medication is an effective treatment for many of the symptoms associated with ADHD (qtd. in
Antshel 72). Stimulant treatments provide many positive benefits, such as; controlled
hyperactivity, improved concentration, increased motivation and socializing skills. Patients on
stimulants become fairly calmer; they are able to stay focused on one task at a time, and are not
easily distracted. Solanto says that it has been shown in previous studies that MPH
(methylphenidate) significantly reduces activity level in children with ADHD and enhances
sustained attention, as well as the speed and organization of motor response processes and motor
inhibitory control (qtd. in Ellertsen et al. 21). Stimulant medications manifest alertness in
patients; therefore, allowing them to become more successful, and productive in their daily
routines. Oftentimes the hyper-focused behavior stimulants exude will push ADHD patients to
become more active, this commonly influences them to take on new hobbies or join school clubs.
The concentration stimulants transmit to patients also motivates them to complete the tasks in
Franco 3
their everyday life that they couldn’t complete before. Patients on stimulant treatment usually
feel self-sufficient, and it is easier for them socialize with others, along with, improving their
family relationships. Miller et al. share that, “In many cases, the medications have also led to
improved relationships with peers and parents, and better control over conduct and aggression”
(qtd. in Doffing et al. 17). Most importantly, stimulants reduce the main symptoms of ADHD
that hold patients back from being triumphant in their life.
In addition, Faraone et al. state, “For most patients with ADHD, stimulants remain the
first choice for medication management, as meta-analyses of existing research have shown that
they are more efficacious than non-stimulant medications” (qtd. in Antshel 72). In the long run,
being on stimulants for treatment of ADHD is a great advantage for those patients who are
accurately diagnosed. If stimulant medications are not abused and are taken as directed by the
psychiatrist then, any improvements patients have made initially can become long term benefits
in their life. Some long term benefits include; improvement in school grades, improvement in
work quality, and an overall organized life. Due to ADHD symptoms, patients are at a
disadvantage compared to their peers because they work at a lower level than the average person,
therefore, patients have trouble exceeding at school or at times even keeping jobs. Patients can
honestly benefit from stimulant medications immensely; they offer assistance to those ADHD
patients who truly need help with concentrating and controlling their impulsivity in places that
are essential parts in their lives. Also, Wilens et al. explain that studies suggest that treatment
with stimulants can help to lessen the likelihood of other psychiatric comorbidities during
adolescence, including cigarette use and substance abuse (qtd. in Antshel 72). Overall,
stimulants can be extraordinarily beneficial in the lives of patients who are suffering from
Attention Deficit Hyperactivity Disorder.
Franco 4
Although stimulant treatments for patients who suffer from ADHD have been somewhat
beneficial, the negative effects it has had on a large portion of patients overshadow any minor
benefit. Schachter et al. express that common adverse effects include; decreases in growth,
headaches/stomachaches, changes in blood pressure and pulse, changes in sleep, increases in tics,
cognitive effects, rebound phenomenon and psychotic behaviors (qtd. in Doffing et al. 17).
Insomnia and loss of appetite are two very well-known side effects stimulants have on patients;
however, they are far more severe than what many people perceive them as. Loss of appetite is
an extremely serious side effect stimulants have; when patients on stimulants forget to eat it can
cause them intolerable migraines and stomach pains that oftentimes sends patients to the
hospital. Likewise, numerous patients have reported that after just two restlessness nights they
began feeling extremely painful muscle cramps all over their body, along with, hallucinating and
becoming paranoid. In the article Atomoxetine/SLI 381 studies discovered, “A restless boy and a
girl developed psychiatric disorders during treatment with SLI 381 [Adderall XR] and
atomoxetine [Strattera] for attention-deficit hyperactivity disorder (“Atomoxetine/SLI 381” 8).
According to Efron, Jarmon, and Barker a comparison study of both medications [amphetamines
and methylphenidate] found that dextroamphetamine caused more severe insomnia, irritability,
proneness to crying, anxiousness, sadness and nightmares, but caused less severe appetite
suppression (qtd. in Doffing et al. 17). Indeed, amphetamines have a similar profile of adverse
effects to methylphenidate, but even when taking dextroamphetamine or methamphetamine the
negative effects of any these stimulants will generally be just as detrimental. Moreover, it is very
common for patients to become extremely anxious when their stimulant dosage is increased; they
begin feeling on edge, jittery and develop tics. Castellanos states that tics may occur or be
increased in some of the patients treated with methylphenidate (qtd. in Doffing et al. 17).
Franco 5
Countless studies have shown that stimulants cause mood swings and many times even trigger
bipolar disorder in ADHD patients. Customarily patients feel extremely joyous when they are
first put on stimulant treatment because it helps them achieve many things, but soon after they
begin feeling a false sense of superiority and acting arrogant towards everyone around them. In
consequence, patients become notably fickle; only feeling content when they are on stimulants,
and once the stimulants begin wearing off patients become terribly emotional. For example,
Schachter et al. say, “Irritability and proneness to crying or whining are reported when the
medication is wearing off” (qtd. in Doffing et al. 17). Stimulants are no different from any other
street drug; it gives patients a false sense of contentment, meanwhile, it is causing severe damage
in their life.
Additionally, stimulants being prescribed to ADHD patients also have extremely harmful
long term effects. Many studies suggest that amphetamines, dextroamphetamine,
methylphenidates, and methamphetamines are the main cause of serious health issues in ADHD
patients. Breggin wrote that Ritalin predisposes effects, such as growth retardation and
irreversible brain damage (qtd. in Mayes et al. 142). Stimulants suppress appetite in patients, as
well as, disrupting their growth in hormones; this causes a stunt of growth in children. Faraone et
al. discuss that a recent review article has shown that treatment with stimulants in childhood
modestly reduced expected height and weight (qtd. in Antshel 72). Since the immediate effects
of stimulants do not usually last too long, eating disorders typically arise in the majority of
patients. When stimulants cause loss of appetite and the patients who are being treated for
ADHD won’t eat, the metabolism gradually slows down. There comes a point when most
patients begin having unhealthy eating habits; while some will gain weight, others will lose
weight. Breggin states that stimulants also cause skin rashes that can become very serious and
Franco 6
even life-threatening allergic reactions can occur (33). Heart and liver problems, along with,
sudden unexplained death are also considered a rare result of long-term stimulant treatment.
According to Joyce et al., significant increases in plasma catecholamines accompanying BP and
heart rate elevations have been reported in adults receiving an intravenous methylphenidate
infusion, and 24-hour ambulatory monitoring in children show higher increases in BP and heart
rate during waking hours, which correlate with stimulant dose (qtd. in Elia and Vetter 165).
Physicians at Thomson Healthcare explain that methylphenidate products now carry warnings
about sudden death in patients with structural cardiac anomalies, long-term growth suppression,
psychosis, mania, aggression, use in severe depression and normal fatigue, patients with
hypertension, other cardiac disorders, visual disturbance and, as noted previously, in individuals
with seizure disorders (Doffing et al. 17).
Lastly, the worse side effect of stimulant treatment is how undeniably addicting it is.
Breggin states that the abuse of methylphenidate can lead to tolerance and severe psychological
dependence; psychotic episodes, violent and bizarre behaviors have been reported. Stimulant
treatment is causing serious addiction problems in many of the patients being treated, since
tolerance for stimulants builds up quickly patients start taking more because their body no longer
feels the stimulant’s effects. Hill and Sofuoglu state that abuse of amphetamine is associated
with tolerance and psychological dependence and is difficult to treat; withdrawal generally
produces fatigue, depression and social disability (qtd. in Berman 123). ADHD patients taking
stimulants are more frequently becoming dependent of stimulant drugs because they feel as if
they can only function adequately while they are on stimulants. Not to mention, there is
significantly large amount of female patients abusing stimulants in order to lose weight.
According to Hill and Sofuoglu, since amphetamines were first used medically, there have been
Franco 7
reports of prescription abuse by individuals seeking weight loss, enhanced energy, sleep
postponement (student 'cramming,' long-distance driving), improved athletic performance or
simply enhancement of recreational social activities (qtd. in Berman 123). These stimulants are
opening doors to other drugs, and causing damage to the patients inflicted. Karch describes the
typical acute behavioral effects of stimulants include feelings of alertness, wakefulness, energy,
well-being, euphoria (at high doses) and suppression of appetite (qtd. in Kish 1679). The
behavioral effects stimulants give patients are quite similar to those of street drugs like cocaine
and crystal meth. Medications are meant to help people; meanwhile, stimulants used for ADHD
are doing the complete opposite.
Apart from stimulants, many other non-stimulant treatments have proven to be just as
effective and contain a significantly smaller amount of negative side effects. Zimmerman
expresses, “Despite use of stimulant medication in childhood, many adolescents continue to have
major attention deficit symptoms such as academic, emotional, or social problems without
additional treatment methods (87). Still, stimulant treatment continues to be used as the sole
treatment for patients with ADHD. For instance, two perfect alternatives for stimulant treatment
are the following; atomoxetine (Strattera), a selective norepinephrine reuptake inhibitor (NRI),
and bupropion (Wellbutrin), a selective serotonin re-uptake inhibitor (SSRI). Strattera and
Wellbutrin are known for running considerably smooth and keeping patients emotionally,
mentally and physically stable. Studies have shown that both Wellbutrin and Strattera cannot be
abused and their side effects are close-to-none. Garnock-Jones and Keating believe that
atomoxetine is effective and generally well tolerated (85). Another successful form of treatment
for ADHD is a nutritional diet. Zimmerman explains that it only takes a few days for there to be
observable improvement in children’s behavior when the most likely provoking foods and
Franco 8
additives are removed from their diet; this makes diet the best place to start in overcoming
AD/HD (91). Furthermore, non-stimulant treatment for ADHD should be taken up for
consideration more often because stimulants can be highly dangerous if given to the wrong
patient.
In brief, people are casually being diagnosed with ADHD and given stimulant treatment
regardless of how damaging it can be. Swanson et al. express, “Drug treatment should be based
on a thorough assessment and should always be part of a comprehensive treatment plan that
includes psychosocial, behavioral, and educational advice and interventions” (qtd. in Curatolo et
al. 79). Though, it is true that ADHD patients honestly deserve to have effective treatment
because they are at a high disadvantage compared to other people who don’t have ADHD, there
are several ways to treat ADHD patients and stimulants are not the only option. Johnston et al.
believe, “The goal of all of ADHD therapies is to help patients focus more, and therefore
improve their symptoms” (qtd. in McCarthy 66). Stimulants used in ADHD treatment are surely
capable of providing patients with positive results; still, the detrimental effects caused by
stimulants definitely outweigh any benefits they may offer.
Franco 9
Works Cited
Antshel, Kevin M., Stephen V. Faraone, Teresa M. Hargrave, Kaitlin Hendricks, Prashant Kaul,
and Mihai Simonescu. "Advances in understanding and treating ADHD." BMC Medicine
9 (2011): 72. Academic OneFile. Miami Dade College. Web. 9 Nov. 2011.
"Atomoxetine/SLI 381: hallucinations, paranoid disorders and mania in children: 2 case reports."
Reactions Weekly 7 Feb. 2009: 8. Academic OneFile. Miami Dade College. Web. 10 Oct.
2011.
Berman, S.M., et al. "Potential adverse effects of amphetamine treatment on brain and behavior:
a review." Molecular Psychiatry 14.2 (2009): 123+. Academic OneFile. Miami Dade
College. Web. 15 Nov. 2011.
Breggin, Peter R. Talking Back To Ritalin: What Doctors Aren’t Telling You About Stimulants
And ADHD. Cambridge, Mass: Perseus, 2001. Print.
Curatolo, Paolo, Elisa D’Agati, and Romina Moavero. "The neurobiological basis of ADHD."
Italian Journal of Pediatrics 36 (2010): 79. Academic OneFile. Miami Dade College.
Web. 8 Nov. 2011.
Doffing, Melissa, Laura McGuinn, and Mark L. Wolraich. "Treatment of attention deficit
hyperactivity disorder in children and adolescents: safety considerations." Drug Safety
30.1 (2007): 17+. Academic OneFile. Miami Dade College. Web. 9 Nov. 2011.
Elia, Josephine, and Victoria L. Vetter. "Cardiovascular effects of medications for the treatment
of attention-deficit hyperactivity disorder: what is known and how should it influence
Franco 10
prescribing in children?" Pediatric Drugs 12.3 (2010): 165+. Academic OneFile. Miami
Dade College. Web. 9 Nov. 2011.
Ellertsen, Bjorn, et al. "Methylphenidate improves motor functions in children diagnosed with
Hyperkinetic Disorder." Behavioral and Brain Functions 5.21 (2009): 21. Academic
OneFile. Miami Dade College. Web. 9 Nov. 2011.
Froehlich, Tanya E., James J. McGough, and Mark A. Stein. "Progress and promise of attention-
deficit hyperactivity disorder pharmacogenetics." CNS Drugs 24.2 (2010): 99+.
Academic OneFile. Miami Dade College. Web. 8 Nov. 2011.
Garnock-Jones, Karly P., and Gillian M. Keating. "Spotlight on atomoxetine in attention-deficit
hyperactivity disorder in children and adolescents." CNS Drugs 24.1 (2010): 85+.
Academic OneFile. Miami Dade College. Web. 9 Nov. 2011.
Kish, Stephen J. "Pharmacologic mechanisms of crystal meth." CMAJ: Canadian Medical
Association Journal 17 June 2008: 1679+. Academic OneFile. Miami Dade College.
Web. 10 Oct. 2011.
Mayes, Rick, Catherine Bagwell, and Jennifer L. Erkulwater. Medicating Children: Adhd and
Pediatric Mental Health. Cambridge, Mass: Harvard University Press, 2009. Print.
McCarthy, Alice A. "Misuse and abuse of ADHD medication: when used as prescribed, these
drugs are not addictive. However; abuse is on the rise, and clinicians need to be able to
identify the signs." Clinical Advisor Nov. 2010: 66+. Academic OneFile. Miami Dade
College. Web. 10 Oct. 2011.
Franco 11
Singh, Ilina. "Beyond polemics: science and ethics of ADHD." Nature Reviews Neuroscience
9.12 (2008): 957+. Academic OneFile. Miami Dade College. Web. 8 Nov. 2011.
Zimmerman, Marcia. The ADD nutrition solution: a drug-free thirty day plan. New York: Holt,
1999. Print.