report, article

Report 1500 words

Write a report about the understanding of the experiments conducted in the article

“Protein disulfide isomerase inhibitors constitute a new class of antithrombotic agents”

Questions to address in a writing a research report

· What is missing/gap in our knowledge?

· What is the study trying to address (research question or aim)?

· What are the tools/assays/model used to address the aim?

· What did they find?

· Is there any surprise in the findings?

· How did the findings fit into our current knowledge?

· What is the deficiency of the study?

Report structure:

Introduction

−Introduce the topic (thrombosis, inflammation, thiol isomerase, etc)

−What is missing in the field

−Introduce the paper you would be discussing in the report (hypothesis, aims, etc)

Methods

−What kinds of tools, assays, models did the authors employ (talk about those that match your results)

−What were the controls included in the study

Results

−What did the authors find (you may only have space to discuss 3-4 pieces of data), pick those that make a story

−Can include the figures as long as you reference it

Discussion

−How did the findings fit into our current knowledge?

−Are the findings relevant to existing practice (such as treatment or therapuetics)?

−Is there any deficiency in the study?

References and in-text citations

For additional information for the background or discussion external article can be used as well as the following:

· Cho, J., Furie, B.C., Coughlin, S.R., and Furie, B. (2008). A critical role for extracellular protein disulfideisomerase during thrombus formation in mice. J Clin Invest 118, 1123-1131.

· Li, J., Kim, K., Jeong, S.Y., Chiu, J., Xiong, B., Petukhov, P.A., Dai, X., Li, X., Andrews, R.K., Du, X., et al. (2018). Platelet Protein DisulfideIsomerase Promotes Glycoprotein Ibalpha-Mediated Platelet-Neutrophil Interactions Under ThromboinflammatoryConditions. Circulation 139, 1300-1319.

· Passam, F., Chiu, J., Ju, L., Pijning, A., Jahan, Z., Mor-Cohen, R., Yeheskel, A., Kolsek, K., Tharichen, L., Aponte-Santamaria, C., et al. (2018). Mechano-redox control of integrin de-adhesion. Elife7, e34843.