Organizations

Q1: Review the study titled “Epigenetics: molecular mechanisms and implications for disease” and answer in detail the following questions:

A. Is there a connection between DNA methylation and histon modification?

B. Is epigenetics relevant to medicine?

C. What is the epidemiological evidence of epigenetics?

D. Is the epigenome inherited between generations?

E. How do environmental factors influence the epigenome?

Q2: Review the study titled “Why nature prevails over nurture in the making of the elite athlete” and answer in detail the following questions:

A. Is there a significant genetic component to various parameters that ultimately determine elite performance? Explain

B. Identify the epigenetic role in elite human performance.

Q3: Review the study titled “Prior alcohol use enhances vulnerability to compulsive cocaine self-administration by promoting degradation of HDAC4 and HDAC5” and answer in detail the following questions:

A. Identify risk factors for cocaine addiction.

B. Describe the findings of this study as presented in figure 5.

A.

B.

C.

D.

E.

F.

C. Explain the mechanism by which environmental factors may alter the epigenetic landscape of the reward system to increase vulnerability to cocaine addiction.