Clinical Pharma replies

POST # 2: ANTUNEZ

Pharmacodynamics and Pharmacokinetics

Selective serotonin Inhibitors drugs as an antidepressant example, are used to treat obsessive-compulsive and depression disorder. An example of these drugs is the Fluoxetine and Paroxetine, which produces inhibition of the cytochrome P450 2D6. The medicine also inhibits other cytochrome P450 enzymes like 2C19, 3A4, 2C9/10, and 2C19. The administration of these drugs can reduce the rate of clearing simultaneously administered drugs which depends on oxidative metabolism (Yuet, 2019). The pharmacodynamics of the selective serotonin inhibitors operate by increasing the level of extracellular in the neurotransmitter serotonin. This causes the reduction of its reabsorption back to the presynaptic cells which results in the increase of serotonin level in the synaptic left.

Corticosteroids are some drugs that reduce the rate of inflammation in the body (Joels, 2018). The pharmacokinetic characteristics of the corticosteroids include high protein-binding rapid and systematic clearance. For the inhaled pharmacokinetic, it has pharmacokinetic characteristics of lowering the oropharyngeal exposure, onsite activation in the lung, and the negligible oral bioavailability that the pharmacodynamics of the drugs act depending on the hypothalamic-pituitary-adrenal axis. The mechanism used by the drug is intercellular and its effect persists even after the corticosteroids. The results of the drugs are highly dependent on the age and onset of the anti-inflammatory effects (Woo & Robinson 2015). References

Joëls, M. (2018). Corticosteroids and the brain. Journal of Endocrinology, 238(3), R121-R130.

Woo, T. M., & Robinson, M. V. (2015). Pharmacotherapeutics for advanced practice nurse prescribers. FA Davis.

Yuet, W. C., Derasari, D., Sivoravong, J., Mason, D., & Jann, M. (2019). Selective Serotonin Reuptake Inhibitor Use and Risk of Gastrointestinal and Intracranial Bleeding. The Journal of the American Osteopathic Association, 119(2), 102-111.