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PEDIATRICPHARMACOLOGYWORKBOOKMODULE2-3.docx

Pediatric Pharmacology Workbook:

Module 2

Objectives:

· Describe the pharmacological differences in the pediatric patient.

· Describe the pharmacodynamics and pharmacokinetics of the pediatric patient.

· Formulate an anesthesia plan of care for the pediatric patient based on the pharmacological changes which occur throughout the lifespan.

· Describe the physiological changes in the neonate, infant and child and its effects on pediatric pharmacology.

Describe why neonates and children have significant differences in their dynamic response to drugs as compared to adults:

Describe the variables for pharmacokinetics:

Absorption:

Distribution:

Metabolism:

Elimination:

Describe the immature blood brain barrier in the pediatric patient:

Describe the neuromuscular junction of the neonatal patient:

Describe the adverse effects of succinylcholine in the pediatric patient:

Describe the antagonism of neuromuscular blocking drugs:

Describe the pharmacokinetics of inhalation agents for the pediatric patient:

Wash in:

Factors affecting delivery of anesthetics to the lungs:

Describe uptake and distribution:

MAC doses:

Anesthetic management of oxygen: Hyperoxemia and retinopathy of prematurity

Adverse effects of Nitrous oxide:

Describe benzodiazepines in the pediatric patient:

Describe the effect of intravenous anesthetics on the pediatric patient:

Propofol:

Ketamine:

Etomidate:

Opioids:

Acetaminophen:

Ketorolac:

Dexmedetomedine:

Anticholinergics: