Altered Physiology

Identify the genes that may be associated with the development of the disease.

A variety of gene pairs are associated with the RA condition as significant risk factors. The causative genes to the condition are suspended in the immune system function ( citation). Change in human Leukocyte antigen genes (HLA) in the significant contributor to Rheumatoid Arthritis ( citation needed). The genes, RLA-DRB1, are highly associated with triggering the Rheumatoid Arthritis condition. It is associated with the production f body proteins. The HLA proteins assist the immune system in distinguishing immune proteins and those proteins produced by body invaders like viruses (Soo P, n.d). Variation in other genes has a little impact on the condition ( citation needed).

 Explain the process of immunosuppression and the effect it has on body systems.

Immunosuppression is a process that subdues the human immune system to individuals undergoing organ transplants or those with autoimmune conditions like Rheumatoid Arthritis(>>>>>>>>). The process involves administering drugs to ensure that the immune system does not repel the organs being transplanted (McCance & Huether, 2019). The physicians must first carry an examination of different body organs them makes a prescription to the patient. After the examination, a strict medical plan or therapy session is created, which patients should stickily follow. During the process, the doctor monitors the patients effectively on a close observation. Immunosuppression has different side effects in the body, some of which arise due to the drugs ( citation needed). The effects include; decrease in bony density, a decrease in muscle functioning, effect on the operation of muscle fiber, which reduces muscle protein production and cases of hyperglycemia and severe diabetes. The effects get controlled through regular exercise. This paragraph should lead to the 4th or next paragraph this p

Invasive Aspergillosis is a condition resulting from inhaling spores available in the environment. The spores germinate and enter blood vessels resulting in the condition. Risk factors associated with the condition include organ transplant and neutropenia. The condition is common to individuals with immunosuppression or immunocompromised patients (McCance & Huether, 2019). Invasive Aspergillus mostly infect open spaces like the pulmonary cavities. A flavus commonly results in the condition for this case as it is more pronounced to individuals severely immunosuppressed than those infected by A. fumigatus. In the lungs, focal infection results in the formation of Aspergilloma enclosed by fibrous tissues. At times the fungi invade local areas but mostly reside in the cavity. The chronic invasive Aspergillosis commonly infects patients prescribed with the long-term corticosteroid. With the case projected in this paper, the patients attracted the spores in the environment during his daily duty.

What gene are affected with this diseases? This paper focused more on the RA instead of the Invasive Aspergillosis,

How does RA and Invasive Aspergillosis relate together?

Detailed and specific analysis of the genes that may be associated with the development of the disease.

Explain why you think the patient presented the symptoms described.

References

McCance, K. L. & Huether, S. E. (2019). Pathophysiology: The biologic basis for disease in adults and children (8th ed.). St. Louis, MO: Mosby/Elsevier.