Graduate power point on HIV
Laura’s Cushing Syndrome
Exogenous (iatrogenic)
Endogenous
Administration of corticosteroids
Corticotropin
dependent
(Laura’s type)
Corticotropin
independent
Pituitary adenoma
(Laura’s type)
Adrenal
tumor
Macronodular adrenal hyperplasia
Primary
Pigmented
Nodular
Adrenal
Disease
Excessive levels of ACTH and cortisol
Weight gain
Glucose
Intolerance
Protein
wasting
Loss of collagen
Suppressed immune system
Increased adrenal
androgen levels
Truncal obesity
Moon face
Buffalo hump
Diabetes mellitus
Muscle wasting
Bone resorption
Osteoporosis
Fractures
Purple striae
Skin breaks
Ulcerations
Susceptibility to infections
Poor wound healing
Hair growth (facial)
Acne
Oligomenorrhea
Ectopic
ACTH-secreting tumors
Increased
Melanocyte-stimulating
hormone
Hyper-pigmentation of
mucous membranes,
hair, and skin
Auto-immune disorder
Walter’s Adenocarcinoma of the Lung
Smoking
Family History
Chronic Disease
Environmental Factors
Wife smokes
Pancreatic & uterine cancer
COPD, pulmonary fibrosis, & tuberculosis
Air pollution
Cancer is caused by repetitive insults to the bronchial mucosa that result in multiple mutations in the genome of susceptible cells
Growth of abnormal cells, multiply out of control and form tumor
Tumors usually arise from the peripheral regions of the pulmonary parenchyma
Complications
GI symptoms
Exudative effusions
Empyema
Superior vena cava syndrome
Brain metastasis
Pneumothorax
Pleural effusions
Chemical exposure