Graduate power point on HIV

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Laura’s Cushing Syndrome

Exogenous (iatrogenic)

Endogenous

Administration of corticosteroids

Corticotropin

dependent

(Laura’s type)

Corticotropin

independent

Pituitary adenoma

(Laura’s type)

Adrenal

tumor

Macronodular adrenal hyperplasia

Primary

Pigmented

Nodular

Adrenal

Disease

Excessive levels of ACTH and cortisol

Weight gain

Glucose

Intolerance

Protein

wasting

Loss of collagen

Suppressed immune system

Increased adrenal

androgen levels

Truncal obesity

Moon face

Buffalo hump

Diabetes mellitus

Muscle wasting

Bone resorption

Osteoporosis

Fractures

Purple striae

Skin breaks

Ulcerations

Susceptibility to infections

Poor wound healing

Hair growth (facial)

Acne

Oligomenorrhea

Ectopic

ACTH-secreting tumors

Increased

Melanocyte-stimulating

hormone

Hyper-pigmentation of

mucous membranes,

hair, and skin

Auto-immune disorder

Walter’s Adenocarcinoma of the Lung

Smoking

Family History

Chronic Disease

Environmental Factors

Wife smokes

Pancreatic & uterine cancer

COPD, pulmonary fibrosis, & tuberculosis

Air pollution

Cancer is caused by repetitive insults to the bronchial mucosa that result in multiple mutations in the genome of susceptible cells

Growth of abnormal cells, multiply out of control and form tumor

Tumors usually arise from the peripheral regions of the pulmonary parenchyma

Complications

GI symptoms

Exudative effusions

Empyema

Superior vena cava syndrome

Brain metastasis

Pneumothorax

Pleural effusions

Chemical exposure