Presentation
Rocky11
Nil_ResearchJournalProject.pptxBiochemical transformation of bacterial lipopolysaccharides by acyloxyacyl hydrolase reduces host injury and promotes recovery
Nil PATEL (chem – 4427)
InTRODUCTION
Immune responses induced by Microbe-Associated molecular patterns (MAMPs) are critical for the body's defense against pathogens.
This article discussed how AOAH may increase sensitivity to pulmonary allergens.
Researchers reviewed recent progress in understanding how this enzyme, acyloxyacyl hydrolase (AOAH), transforms LPS from stimulus to inhibitor, and keeps stimulatory LPS from entering the bloodstream.
SENSING LIPOPOLYSACCHARIDES
From stimulus to inhibitor: the importance of LPS acylation
STRUCTURE & BIOSYNTHESIS OF AOAH
Cellular sources of AOAH
AOAH prevents, moderates, and terminates responses to LPS
IS AOAH An essential gene? OR HAVE ANY Disease associations?
Conclusions
