Module 4-WEEKLY NOTE – CHAPTER 4
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Module4WeeklyNote.docxChapter 4 Outline
Psychosis, Schizophrenia, and the Neurotransmitter Networks Dopamine, Serotonin, and Glutamate
Module 4 Weekly Note. Address each heading in the yellow outline note.
Read Chapter 4. pages 77- 158. No reference needed.
Symptoms of Psychosis 77
The Three Major Hypotheses of Psychosis and Their Neurotransmitter Networks 78
The Classic Dopamine Hypothesis of Psychosis and Schizophrenia 79
The Dopamine Neurotransmitter Network 79
The Classic Dopamine Hypothesis of the Positive Symptoms of Psychosis: Mesolimbic HyperDopaminergia 90
Corollary to the Classic Dopamine Hypothesis of Schizophrenia: Mesocortical HypoDopaminergia and the Cognitive, Negative, and Affective Symptoms of Schizophrenia 95
The Glutamate Hypothesis of Psychosis and Schizophrenia 95
The Glutamate Neurotransmitter Network 96
The NMDA Glutamate Hypofunction Hypothesis of Psychosis: Faulty NMDA Neurotransmission at Glutamate Synapses on GABA Interneurons in Prefrontal Cortex 105
The Serotonin Hypothesis of Psychosis and Schizophrenia 111
The Serotonin Neurotransmitter Network 113
The Serotonin Hyperfunction Hypothesis of Psychosis 131
Summary and Conclusions Regarding Dopamine, NMDA, and Serotonin Neurotransmission in Psychosis 141
Schizophrenia as the Prototypical Psychotic Disorder 141
Beyond the Positive and Negative Symptoms of Schizophrenia 143
What Is the Cause of Schizophrenia? 148
Other Psychotic Illnesses 156
Mood-Related Psychosis, Psychotic Depression, Psychotic Mania 157
Parkinson’s Disease Psychosis 157
Dementia-Related Psychosis 157
Summary 158
