Module 05 Discussion - Viral Treatment Options
Angeila
MicrobiologyDiscussion.docxDirections:
While established vaccines are generally safe for the vast majority of the population, it is a fact that for a minority of people, certain vaccines are contraindicated. In particular, it is well known that people with immunodeficiency are advised against receiving live attenuated vaccines.
Less-often discussed is the possibility of (for some people) of autoimmune reaction. This is not only an issue with regard to vaccines, but synthetic chemicals as well (as well as potential allergy development from cross reactivity / bystander effect some individuals' immune systems may be predisposed to engage).
For Part 1 of your initial post, examine at least one of the three paper attachments and summarize at least one point / comment regarding your chosen document(s) in your initial post. You don't need to read the entire document(s), but please do at least read the Abstracts, and be sure to include a comment on one point or simply a summary of the abstract in your own words.
The " bystander effect" or as some texts call it, " cross-reactivity" ( microbiology definition) is: When immune cells detect a legitimate threat in the body, sometimes "innocent bystander" molecules or body cells "get in the way of its attack" and become unfortunate targets themselves. This could include otherwise perfectly harmless food molecules, or even parts of the body such as neurons' myelin sheaths, or pancreas cells.
Such challenges are admittedly rare, yet not nonexistent.
This first paper on autoimmunity discusses how sometimes such mechanisms can occur in response to antigens (including antigens in vaccines), and was published in 2015:
Autoimmunity paper.pdf
The following paper is more relevant to specific results of autoimmunity in response to antigens as varied as viruses or particles in certain vaccines (i.e. myocarditis and pericarditis) - this is an extremely recent paper (published June 2022):
Risks of myocarditis and pericarditis following Covid-19 mRNA vaccines.pdf
The third paragraph of the discussion section of this below paper (published recently, February 2022) discusses autoimmune mechanisms regarding the Covid spike protein getting potentially expressed in the liver in particular:
[Side note: As of the start of 2023, many, many more scientific papers documenting autoimmune adverse reactions of many more body systems have been published. I've cataloged 7+ such papers on vasculitis alone, as well as a very thorough report of other types of ADRs for example, if you want to see more data than I can reasonably fit into this discussion post for options.
Evidence (and further questions) regarding how Covid vaccine mRNA interacts with our genome.pdf
There are however many viral diseases for which vaccines are not even available (or viral variants for which vaccines are possibly less than 15-50% effective), which brings us to "antiviral chemicals" as a good adjunct treatment (or, in some cases, the sole treatment) option for certain diseases.
Thus, for Part 2 of your initial post, we will focus on "after-the-fact" antiviral treatment options:
Examine at least one of the below papers (or a similar one, any result of your typing in a "antiviral" of choice along with the keyword "antiviral"), and make at least one comment about it as well, as part of your initial post.
The first two papers below have been added as attachments (actually the second attachment is a list of links to a BUNCH of papers!); the rest of the papers below are in "link" form.
Remember if you want to download the "attachment", click on the three dots to the right of the title:
Eugenol, a Component of Holy Basil (Tulsi) and Common Spice Clove, Inhibits the Interaction Between SARS-CoV-2 Spike S1 and ACE2 to Induce Therapeutic Responses - 11481_2021_Article_10028.pdf
Evidence of elderberry antiviral and immunomodulatory properties.docx
In silico allicin induced S-thioallylation of SARS-CoV-2 main protease
Allicin inhibits SARS-CoV-2 replic
Antiviral agents for rhinovirus (a type of common cold)
How curcumin (in turmeric) interacts with Covid proteins
How piperine (in black pepper) interacts with Covid proteins
Zinc inhibits SARS-CoV RNA polymerase, and thus its replication capacity
How 9 of 48 compounds in cinnamon interact with Covid proteins
Antiviral activity of licorice extract against respiratory syncytial virus
