Evidence-Based Interventions Used in Trauma

profileDena87
MarzilliE.CernigliaL.CiminoS.2018.AnarrativereviewofbingeeatingdisorderinadolescencePrevalenceimpactandpsychologicaltreatmentstrategies..pdf

© 2018 Marzilli et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms. php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work

you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

Adolescent Health, Medicine and Therapeutics 2018:9 17–30

Adolescent Health, Medicine and Therapeutics Dovepress

submit your manuscript | www.dovepress.com

Dovepress 17

R E V I E W

open access to scientific and medical research

Open Access Full Text Article

http://dx.doi.org/10.2147/AHMT.S148050

A narrative review of binge eating disorder in adolescence: prevalence, impact, and psychological treatment strategies

Eleonora Marzilli1

Luca Cerniglia2

Silvia Cimino1

1Department of Dynamic and Clinical Psychology, Psychology and Medicine Faculty, Sapienza – University of Rome, 2Department of Psychology, Psychology Faculty, International Telematic University Uninettuno, Rome, Italy

Abstract: Binge eating disorder (BED) represents one of the most problematic clinical condi- tions among youths. Research has shown that the developmental stage of adolescence is a critical

stage for the onset of eating disorders (EDs), with a peak prevalence of BED at the age of 16–17

years. Several studies among adults with BED have underlined that it is associated with a broad

spectrum of negative consequences, including higher concern about shape and weight, difficulties

in social functioning, and emotional-behavioral problems. This review aimed to examine studies

focused on the prevalence of BED in the adolescent population, its impact in terms of physical,

social, and psychological outcomes, and possible strategies of psychological intervention. The

review of international literature was made on paper material and electronic databases ProQuest,

PsycArticles, and PsycInfo, and the Scopus index were used to verify the scientific relevance of

the papers. Epidemiological research that examined the prevalence of BED in adolescent samples

in accordance with Diagnostic and Statistical Manual of Mental Disorders, 4th Edition showed

a prevalence ranging from 1% to 4%. More recently, only a few studies have investigated the

prevalence of BED, in accordance with the Diagnostic and Statistical Manual of Disorders, Fifth

Edition criteria, reporting a prevalence of ~1%–5%. Studies that focused on the possible impact that BED may have on physical, psychological, and social functioning showed that adolescents

with BED have an increased risk of developing various adverse consequences, including obesity,

social problems, substance use, suicidality, and other psychological difficulties, especially in the

internalizing area. Despite the evidence, to date, reviews on possible and effective psychological

treatment for BED among young population are rare and focused primarily on adolescent females.

Keywords: binge eating, adolescence, prevalence, impact, treatment

Introduction Binge eating disorder (BED) is an empirically validated eating disorder (ED),1–3 intro-

duced in May 2013 in the Diagnostic and Statistical Manual of Disorders, Fifth Edi-

tion (DSM-5).4 BED is characterized by recurrent episodes of unusually large amount

of food intake without compensatory behaviors, and it is associated with subjective

experience of feeling of loss of control (LOC) and marked distress.5–8 Originally, BED

was introduced in the appendix of the Diagnostic and Statistical Manual of Disorders,

4th Edition, Text Revision (DSM-IV-TR),9 as a subcategory of Eating Disorders Not

Otherwise Specified (EDNOS). Criteria required binge eating episodes at least twice

per week for 6 months, but the new DSM-5 changed this threshold to at least once a

week for 3 months.10 Generally, binge eating episodes are preceded by intense feeling

of craving,11 and several researchers have suggested that binge eating may serve as a

maladaptive strategy for coping with negative mood states.12–16

Correspondence: Luca Cerniglia Department of Psychology, Psychology Faculty, International Telematic University Uninettuno, Corso Vittorio Emanuele II, 39 – 00100, Rome, Italy Tel +39 06 69201 Email [email protected]

Journal name: Adolescent Health, Medicine and Therapeutics Article Designation: REVIEW Year: 2018 Volume: 9 Running head verso: Marzilli et al Running head recto: Binge eating disorder in adolescence DOI: http://dx.doi.org/10.2147/AHMT.S148050

A

d o

le sc

e n

t H

e a

lth ,

M e

d ic

in e

a n

d T

h e

ra p

e u

tic s

d o

w n

lo a

d e

d f

ro m

h tt

p s:

// w

w w

.d o

ve p

re ss

.c o

m /

b y

1 7

4 .2

2 7

.3 .7

4 o

n 2

6 -O

ct -2

0 1

8 F

o r

p e

rs o

n a

l u se

o n

ly .

Powered by TCPDF (www.tcpdf.org)

1 / 1

Adolescent Health, Medicine and Therapeutics 2018:9submit your manuscript | www.dovepress.com Dovepress

Dovepress

18

Marzilli et al

BED is the most prevalent form of ED and one of the

primary chronic illnesses among adolescents.17 Adolescence

is a transitional developmental stage characterized by rapid

and deep physical, psychological, and neural development

changes, and it represents a critical period for the onset of

EDs, including BED.18–21 During this period, youths experi-

ence fast neurobiological and body modifications, which

may be accompanied by increased concern and attention

for body size and shape,22–24 as the awareness of societal

pressures for thinness and relationships with peers becomes

increasingly important, leading to a higher concern about peer

acceptance.25–27 For these reasons, although EDs can affect

individuals of all ages, adolescence represents a peak lifetime

period of increased vulnerability for the onset of EDs.28,29 In

particular, an increased prevalence of ED symptoms among

youths aged 14–16 years has been evidenced,30 with two

peaks of onset of BED, the first immediately after puberty, at

a mean age of 14 years,31 and the second in late adolescence

(19–24 years), between 18 and 20 years.32

In the general population, international research has

reported that 26% of female and 13% of male adolescents

have experienced an episode of binge eating at least once in

the last 12 months33 and that subclinical symptoms of BED

can be associated with a higher risk of developing BED34

and/or other adverse outcomes, including lower self-esteem

and higher body dissatisfaction.35

It is noteworthy that binge eating episodes in adolescence

could be difficult to differentiate from nonclinical behaviors,

as youths could indulge in large food consumption due the

developmentally specific growth spurts.36 Consequently, it has

been suggested that the criterion of LOC eating is the most

salient marker of BED in this developmental phase, especially

for early adolescents.37 Furthermore, adolescents may also

show less frequent episodes of binge eating than it is neces-

sary to pose a diagnosis of BED according to the Diagnostic

and Statistical Manual of Mental Disorders.18,38,39 For these

reasons, it is important for clinicians to consider subthreshold

binge eating disorder (SBED) in adolescents.32,34,37,40

It has also been evidenced that female adolescents fre-

quently report less overeating than male adolescents,41 but

more severe indicators of loss of control,10,42 and distress

during binge eating episodes.10,41 Moreover, several studies

among adults with BED have shown that this ED is associated

with various adverse consequences, including higher distress

and concern about shape and weight,43 social impairment,8,44

and both clinical and subclinical forms of psychological

difficulties, especially anxiety and depressive symptoms.7

Based on these theoretical and empirical premises, the

aim of this narrative review was to examine the current

knowledge45 of the prevalence of BED in adolescent popula-

tion, outcomes associated in terms of physical, social, and

psychological consequences, and possible psychological

strategies of intervention.

Research methods The methodological approach adopted in this paper consists

of a narrative review,45,46 an interpretive-qualitative form of

research that, when include some features of a systemic meth-

odology,47 can allow synthesizing the findings of literature

about a specific theme and improve our knowledge on the

topic.48 Specifically, our methodological research (Table 1)

was inspired by the four steps provided by Egger et al49 as

follows: 1) formation of a working group, composed of three

operators expert in BEDs; one of them has acted as a meth-

odological operator and the other two as clinical operators;

2) formulation of the review questions on the basis of the

state of the art of BED in adolescent population (in terms

of its prevalence, impact, and possible psychological treat-

ment strategies), as made in the abstract; 3) identification

of relevant studies: the review of international literature was

performed through an extensive search on paper materials in

university libraries and through electronic databases such as

ProQuest, PsycArticles, and PsycInfo and indexing papers

published from January 2007 to June 2017, together with

the use of Scopus index to verify the scientific relevance

of papers. First, in order to examine the prevalence rates of

binge eating in adolescent population, we were specifically

interested in articles that reported the prevalence of both BED

and SBED, in accordance with DSM-IV and DSM-5 criteria,

and assessed diagnoses with self-report questionnaires and/

or interview instruments. Despite self-report measurements

have methodological limitations compared with interview-

based assessments, we also included studies using report

data to classify diagnoses, because epidemiological research

of BED in adolescence is still scarce, and these studies may

provide important preliminary data for future studies. This

research was performed by using relevant combined keywords

such as “binge eating disorder,” “BED,” “subthreshold BED,”

“adolescent,” “youth,” “prevalence,” and “epidemiology.”

Second, to explore the possible impact of BED on ado-

lescents’ health and mental health, we searched for studies

presenting physical, social, and psychological outcomes in

female and male adolescents with BED and SBED, using the

following combined search terms: “adolescence,” “binge eat-

ing,” “subthreshold BED,” “outcomes,” “long-term effects,”

“impact,” “correlates,” and “consequences.”

Finally, to examine the research focused on possible

psychological treatment strategies, we used the keyword

A

d o

le sc

e n

t H

e a

lth ,

M e

d ic

in e

a n

d T

h e

ra p

e u

tic s

d o

w n

lo a

d e

d f

ro m

h tt

p s:

// w

w w

.d o

ve p

re ss

.c o

m /

b y

1 7

4 .2

2 7

.3 .7

4 o

n 2

6 -O

ct -2

0 1

8 F

o r

p e

rs o

n a

l u se

o n

ly .

Powered by TCPDF (www.tcpdf.org)

1 / 1

Adolescent Health, Medicine and Therapeutics 2018:9 submit your manuscript | www.dovepress.com Dovepress

Dovepress

19

Binge eating disorder in adolescence

search function by entering the following terms: “binge eating

disorder,” “adolescence,” “youth,” “psychological treatment,”

“psychotherapy,” and “intervention.”

Given that the criterion of LOC eating has been sug-

gested to be a more appropriate indicator of binge eating in

adolescence with respect to amount of food consumed,37 we

also included treatment studies specifically focused on the

reduction of LOC.

We examined the title and screened abstracts of each

identified article using these initial search strategies. Then,

we also conducted a hand-search of the reference lists of

published articles, and papers were inspected for their rel-

evance in the review. On the basis of the evidence of two

peaks of onset for BED31,32 (the first in early adolescence

and the second in late adolescence),50 we included in this

review only articles in which sample of adolescents was

aged between 10 and 24 years. Furthermore, we selected

only papers in which sample or subsample of adolescents

was diagnosed with BED or SBED, in accordance with

either DSM-IV or DSM-5 criteria, or studies that examined

binge eating symptoms and/or episodes without compensa-

tory behaviors. Other inclusion criteria were that articles in

English language and published in peer-reviewed journals.

Thesis dissertations were excluded.

The final step is 4) the analysis and presentation of the

outcomes; we identified a total of 25 articles, 00 for preva-

lence,10,18,39,40,51–53,59–62 11 for outcomes,18,39,40,59–61,64–68 and 6 for

psychological treatment.79–84 The data extrapolated from these

revised studies were collocated in tables and carried out in

the form of a narrative review. Table 1 shows the summary

of the methodology used in the review. The flow diagram of

the narrative review is shown in Figure 1.

Results Prevalence of BED in adolescence Given that BED has only recently been introduced into the

psychiatric nomenclature, epidemiological research is very

limited, especially for adolescent populations. We found 13

prevalence studies specifically focused on youths, which have

used different types of measurements to assess diagnoses

(Table 2). Five studies18,40,51–53 have examined the prevalence

of BED in accordance with Diagnostic and Statistical Manual

of Mental Disorders, 4th Edition (DSM-IV) and overall

reported a rate of prevalence from 1% to 4%. For example, a

study by Decaluwé and Braet51 in a population of obese ado-

lescents, using interview measurements, has reported a rate of

~2%. Two other studies52,53 have examined the rate of BED in general adolescent population, but using self-report question-

naires, reporting a slightly lower prevalence of 1.2%, with

a higher rate among female adolescents. These studies51,52

have also underlined the presence of high percentage of

youth who did not meet full-threshold criterion for an ED

diagnoses, suggesting limitations of classification systems

for epidemiological research among adolescent populations.

Finally, we considered two studies18,40 that, using interview-

based assessments, have provided the prevalence rates also for

SBED, evidencing a higher prevalence of this form in this phase

of development. One study40 was focused only on adolescent

girls, finding a rate of 1% for BED and 4.6% for SBED. The

second study18 had considered both sexes of adolescent popu-

lation, reporting a prevalence of 1.6% for BED and 2.5% for

SBED and evidencing higher rates among girls for SBED also.

Changes to diagnostic criteria from DSM-IV-TR to

DSM-5 have allowed reducing the prevalence of EDNOS,54

which were ~50% in clinical samples55,56 and 70% in commu-

Table 1 Summary of methodology

Step General activities Specific activities

1 Formation of a working group Three psychologist experts in binge eating disorder: 1. One as a methodological operator 2. Two as clinical operators

2 Formulation of the review questions

Evaluation of the state of the art on the prevalence of BED in adolescence, its impact, and its possible psychological treatment strategies

3 Identification of relevant studies on ProQuest, PsycArticles, and PsycInfo

1. Identification of the keywords on the basis of the field of interest of the papers to be searched, grouped in inverted commas (“…”) and used separately or combined

2. Use of the Boolean AND operator, in order to establish a logical relationship among concepts 3. Research modalities: advanced search 4. Limits: papers published in the last 10 years; languages: English; type of paper: peer-review 5. Manual search through the reference lists of articles, using the Scopus index to verify the

scientific relevance of papers 4 Analysis and presentation of the

outcomes The data extrapolated from revised studies were collocated in tables and presented in the form of a narrative review

Note: Our methodological strategy was inspired by four steps proposed by Egger et al.49

A

d o

le sc

e n

t H

e a

lth ,

M e

d ic

in e

a n

d T

h e

ra p

e u

tic s

d o

w n

lo a

d e

d f

ro m

h tt

p s:

// w

w w

.d o

ve p

re ss

.c o

m /

b y

1 7

4 .2

2 7

.3 .7

4 o

n 2

6 -O

ct -2

0 1

8 F

o r

p e

rs o

n a

l u se

o n

ly .

Powered by TCPDF (www.tcpdf.org)

1 / 1

Adolescent Health, Medicine and Therapeutics 2018:9submit your manuscript | www.dovepress.com Dovepress

Dovepress

20

Marzilli et al

nity samples.57,58 To date, the few studies that have examined

the prevalence of BED in adolescent samples, in accordance

with the recently proposed DSM-5 criteria, found the preva-

lence of approximately between 1% and 5%.10,31,32,39,59–62

In particular, we found three studies39,59,61 that have lon-

gitudinally examined the prevalence of BED in adolescent

community samples and that suggested an increase of rate

over time. For example, Field et al61 found a BED prevalence

of 2.5%, which tended to increase during the development,

with a peak at 19–22 years of age.

Two other studies39,59 have confirmed these findings also

among male adolescent samples. Interesting, a study by Allen

et al59 has reported that BED prevalence increased over time

among female adolescents, starting from 0.7% in 14-year-

old subjects, reaching 1.4% when they were 17 years, and

finally growing up to 4.1% when they were 20 years old.

In male adolescents, BED prevalence was estimated to be

absent (0%) at 14 years of age and 1.2% at 17 years and was

decreased to 0.7% at 20 years, suggesting that adolescent

girls have a higher risk of maintaining BED over the course

of life. However, another study37 found that prevalence of

BED generally increased over time among both female and

male adolescents, peaked at ~3.3% at an age of 22 years for girls and 1.2% at 24 years for boys.

More recently, two cross-sectional studies31,62 have

reported lower rates of prevalence (~1.5%), but among samples of younger adolescents with respects to previous

studies in which an increase of prevalence has been evidenced

over time.

Finally, we considered three studies10,32,60 focused also

on the prevalence of SBED. Interestingly, the study by Stice

et al32 has examined the prevalence of EDs in the same female

Figure 1 Flowchart of narrative review. Note: *Some studies were pertinent to more than one section.

Articles identified through databases (ProQuest, PsycArticles, PsycInfo)

(n=5,006)

Records screened (n=28)

Records excluded (n=4,978)

Reasons: - Not pertinent, n=4,642 - Duplicated, n=298 - Other manuscript type, n=29 - Non-English, n=9

Full-text articles reviewed for potential inclusion

(n=32)* - Prevalence, n=19 - Impact, n=19 - Treatment, n=14

Studies included in narrative review (n=25)*

- Prevalence, n=13 - Impact, n=12 - Treatment, n=6

Articles included from reference lists and citation tracking

(n=4)

Articles excluded (n=7)

Reason: - Wrong study design or

subjects, n=7

A

d o

le sc

e n

t H

e a

lth ,

M e

d ic

in e

a n

d T

h e

ra p

e u

tic s

d o

w n

lo a

d e

d f

ro m

h tt

p s:

// w

w w

.d o

ve p

re ss

.c o

m /

b y

1 7

4 .2

2 7

.3 .7

4 o

n 2

6 -O

ct -2

0 1

8 F

o r

p e

rs o

n a

l u se

o n

ly .

Powered by TCPDF (www.tcpdf.org)

1 / 1

Adolescent Health, Medicine and Therapeutics 2018:9 submit your manuscript | www.dovepress.com Dovepress

Dovepress

21

Binge eating disorder in adolescence

adolescent samples of their previous study,40 but considering

the new DSM-5 criteria, finding an increased prevalence of

BED of ~2%. Two other studies10,60 have replicated similar results but considering also male adolescents. One study60

was consistent with the previous findings, underlining that

female adolescents had a higher prevalence of BED and

SBED with respect to their peer male adolescents. In contrast,

another study10 has evidenced a higher rate of BED among

female adolescents, but male adolescents reported higher

rate of SBED.

Impact of BED on physical, psychological, and social functioning As seen in the above paragraph, epidemiological research

has underlined that BED is common in adolescent popula-

tion. Research that has focused on the possible consequences

of BED on physical, psychological, and social functioning

has evidenced that adolescents suffering from BED have an

increased risk of developing a variety of adverse outcomes,

which may persist into young adulthood.63

Specifically, we reported data from 12 studies showing

that BED in adolescence was predictive of a broad spec-

trum of negative outcomes, including obesity,39,60,61,64 social

impairment,18,64,65 other psychological difficulties, especially

depressive symptoms,39,59–61,64,67,68 anxiety,60,68 and emotional

distress,32,40,68 substance use,39,60,61 and propensity to suicide

and deliberate self-harm18,32,60,66 (Table 3).

Regarding the impact of BED on physical health, four

prospective cohort studies39,60,61,64 have underlined that BED

was predictive of overweight and obesity, both in girls and

boys.39,60,64 In particular, in early adolescents with BED, it has

been reported a body mass index (BMI) of ~23 kg/m2,59 is indicative of a healthy weight. However, among this popula-

tion, BMI tended to increase during later adolescence, with a

mean score of 27 kg/m2 among youths with BED59 and of 26

kg/m2 for SBED,32 representative of a overweight condition

(25 < BMI < 29.9 kg/m2), up to a rate of 60% of obese (BMI >30 kg/m2),31 suggesting that binge eating might represent a crucial risk factor for obesity. A study by Field et al61 has

shown that 35.1% of female adolescents became overweight

Table 2 Prevalence of binge eating disorder in adolescent samples

Reference Age (years) Sample (N) Methods Prevalence (%)

Total Female Male Screening Criteria Total Female Male

Decaluwé and Braet51 10–16 196 111 78 ChEDE DSM-IV 1 1 0 Kjelsås et al52 14–15 1,960 1,026 934 SEDs DSM-IV 1.2 1.5 0.9 Ackard et al53 13–18 4,746 2,373 2,273 EAT DSM-IV 1.1 1.9 0.3 Stice et al40 12–15

20 496 496 – EDDI DSM-IV 1a

4.6b 1a

4.6b –

Swanson et al18 13–18 10,123 – – CIDI DSM-IV 1.6a

2.5b 2.3a

2.6b 0.8a

2.3b

Field et al61 16–24 8,594 8,594 – 2-part questions

DSM-5 2-2.5 – –

Allen et al59 14–17–20 1,383 715 668 ChEDE EDE-Q

DSM-5 0.9 1.3 2.4

1.8 1.4 4.1

0 1.2 0.7

Sonneville et al39 16–24 16,882 9,039 7,843 2-part question

DSM-5 2–3 2.3–3.1 0.3–1

Crow et al62 13–18 10,123 – – 2-part question

DSM-5 1.6 – –

Smink et al31 19 1,597 861 739 CIDI EDE

DSM-5 1.5 2.3 0.7

Stice et al32 12–15 20

496 496 – EDDI DSM-5 3a

3.6b 3a

3.6b –

Micali et al60 14–16 6,140 5,069

3,416 3,059

2,742 2,154

2-part question

DSM-5 0.5a 0.03b

1.15a 0.42b

0.61a

0.03b

1.15a 0.72b

0.33a

0.04b

0.6a 0b

Lee-Winn et al10 13–18 9,336 4,738 4,598 EDDI DSM-5 0.78a

1.33b 1.1a

1.2b 0.46b

1.47b

Note: aThreshold-BED; bsubthreshold BED. Abbreviations: BED, binge eating disorder; ChEDE, Child Eating Disorders Examination; CIDI, Composite International Diagnostic Interview; DSM-IV, Diagnostic and Statistical Manual of Mental Disorders, 4th Edition; DSM-5, Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition; EAT, Eating Attitudes; EDDI, Eating Disorder Diagnostic Interview; EDE-Q, Eating Disorder Examination-Questionnaire; SEDs, Survey for Eating Disorders.

A

d o

le sc

e n

t H

e a

lth ,

M e

d ic

in e

a n

d T

h e

ra p

e u

tic s

d o

w n

lo a

d e

d f

ro m

h tt

p s:

// w

w w

.d o

ve p

re ss

.c o

m /

b y

1 7

4 .2

2 7

.3 .7

4 o

n 2

6 -O

ct -2

0 1

8 F

o r

p e

rs o

n a

l u se

o n

ly .

Powered by TCPDF (www.tcpdf.org)

1 / 1

Adolescent Health, Medicine and Therapeutics 2018:9submit your manuscript | www.dovepress.com Dovepress

Dovepress

22

Marzilli et al

Table 3 Binge eating and physical, social, and psychological outcomes

Reference Age (years)

Sample (N)

Outcome Results (OR; 95% CI) or (p-value) or (Cohen’s d) or (%)

Field et al61 16–24 859 Overweight/obesity Use drugs Binge drink Depressive symptoms

BED was predictive of overweight/obesity (OR: 1.9; CI: 1.0–3.5) and depressive symptoms (OR: 2.3; CI: 1.0–5.0) in female adolescents. No association was found with binge drinking

Sonneville et al39

12–24 14,166 Overweight/obesity Use drugs Binge drink Depressive symptoms

Binge eating was significantly associated with incident overweight/obesity (OR: 1.73; CI: 1.11–2.69), starting to use marijuana (OR: 1.85; CI: 1.27– 2.67) and other drugs (OR: 1.59; CI: 1.08-2.33), and with the onset of high depressive symptoms among both female adolescents (OR: 2.12; CI: 1.32–3.40) and male adolescents (OR: 3.21; CI: 0.68–15.27)

Micali et al64 13–15 7,082 Overweight/obesity Social impairment Family burden Emotional-behavioral disorders

Bingeing/overeating was predictive of higher BMI z scores at 15 years of age (p<0.0001), both in adolescent girls and boys. Bingeing/overeating in girls was associated with social impairment (p<0.0001), burden to parents (p<0.0001), and both emotional (p<0.01) and behavioral (p<0.01) disorder In male adolescents, bingeing/overeating was associated with social impairment (p<0.0001), family burden (p<0.0001), and both emotional (p<0.0001) and behavioral (p<0.0001) disorder

Micali et al60 14–16 6,140 Overweight/obesity Depression Anxiety Alcohol use Substance use Self-harm

BED was prospectively associated with obesity (OR: 3.58; CI: 1.06–12.14), depression (OR: 2.00; CI: 1.06–3.75), anxiety (OR: 3.53; CI: 1.58–7.86), and drug use (OR: 3.39; CI: 1.35–8.48). SBED had prospective associations with depression (OR: 2.11; CI: 1.44–3.10), anxiety (OR: 7.90; CI: 2.53–24.67), drug use (OR: 2.15; CI: 1.14–4.04), and deliberate self-harm (OR: 2.32; CI: 1.43–3.75)

Ranzenhofer et al65

12–17 158 Depressive symptoms Health Social/interpersonal functioning Work/school Mobility Self-esteem Activities of daily living

BED was associated with depressive symptoms (p<0.05), health (p<0.05), mobility (p<0.05), and self-esteem (p<0.01). Adolescent girls, compared to boys, reported lower levels of activities of daily living, mobility, self-esteem, and social/interpersonal functioning (p<0.05), but not health or work/school

Swanson et al18

13–18 10,123 Mental health Social impairment Suicidality

BED and SBED were associated, respectively, to mood disorder (OR: 4.6; CI: 2.7–7.7),a (OR: 2.0; CI: 2.2–3.4);b anxiety (OR: 5.0; CI: 3.0–8.1),a (OR: 1.7; CI: 1.1–2.6);b substance abuse (OR: 3.1; CI: 1.3–7.2),a (OR: 2.7; CI: 1.6–4.6);b and behavioral disorder (OR: 3.1; CI: 1.0–9.4),a (OR: 2.5; CI: 1.4–4.2)b

62.6% of adolescents with BED and 34.6% with SBED reported impairment in the last year, specifically in household chore (45%,a 23.5%b), school or work (46.2%,a 20.6%b), family life (45.7%,a 21.3%b), and social life (51.6%,a 20.9%b). 8.7% of BED and 2.8% of SBED reported several impairment in the domain of household chore (4.8%,a 2.2%b), school or work (1.9%,a 2.6%b), family life (3.7%,a 2.1%b), and social life (5.7%,a 2.1%b). 34.4% of BED and 18% of SBED reported suicidal ideation, 5.1% of BED and 5.1% of SBED declared suicidal plan, and 15.1% of BED and 5.3% of SBED showed suicidal attempt. Finally, they reported significant higher suicidal ideation (p<0.5)a,b and attempt (p<0.05)b than control did

Skinner et al67

12–23 4,798 Depressive symptoms Female adolescents with binge eating or overeating had a higher risk to develop depressive symptoms after 2 years (OR: 1.9; CI: 1.2–2.9 and OR: 1.9; CI: 1.1–3.4, respectively). Female adolescents with depressive symptoms at baseline had a higher risk to start binge eating (OR: 2.3; CI: 1.7–3.0) or overeating (OR: 1.9; CI: 1.4–2.5) at follow-up

Allen et al59 14–20 1,383 Depressive symptoms Physical quality of life Mental quality of life

BED was longitudinally associated with depressive symptoms (p<0.05) and poor mental health quality of life (p<0.05), in both male and female adolescents

Allen et al68 14–20 1,383 Depression Anxiety Psychological functioning

BED was significantly and longitudinally associated with depressive (p<0.01; d=0.73), anxiety (p<0.01; d=1.25), and stress (p<0.01; d=1.31) symptoms and poor mental quality of life (p<0.01; d=0.83) in adolescents with BED

Stice et al40 12–20 496 Mental health service use Functional impairment Emotional distress

Adolescents with BED and SBED reported more mental health treatment (p<0.01), functional impairment (p<0.05), and emotional distress (p<0.01) than the control group

(Continued)

A

d o

le sc

e n

t H

e a

lth ,

M e

d ic

in e

a n

d T

h e

ra p

e u

tic s

d o

w n

lo a

d e

d f

ro m

h tt

p s:

// w

w w

.d o

ve p

re ss

.c o

m /

b y

1 7

4 .2

2 7

.3 .7

4 o

n 2

6 -O

ct -2

0 1

8 F

o r

p e

rs o

n a

l u se

o n

ly .

Powered by TCPDF (www.tcpdf.org)

1 / 1

Adolescent Health, Medicine and Therapeutics 2018:9 submit your manuscript | www.dovepress.com Dovepress

Dovepress

23

Binge eating disorder in adolescence

and/or obese over the following years, with a significant

higher incidence compared with their peers with other EDs.

Three other longitudinal studies39,60,64 have reported similar

findings for both female and male adolescents, evidencing

that binge eating symptoms are predictive of negative physi-

cal consequences (such as obesity) among both sexes.

Furthermore, research has underlined that the impact of

BED in adolescence reaches beyond physical adverse out-

comes. In particular, we considered three studies18,64,65 that

have suggested that the presence of BED was predictive of

a broad spectrum of negative social/interpersonal and out-

comes and lower quality of life, in both obese and general

adolescent population. A study by Ranzenhofer et al65 focused

on an obese adolescent population has shown that binge eat-

ing youths reported severe impairments in the domains of

health, mobility, and self-esteem compared with their peers

without binge eating, even after controlling for body com-

position. At the same time, two studies18,64 have replicated

similar results also in population-based samples, evidenc-

ing that bingeing/overeating symptoms were significantly

associated with both social impairment and family burden, in

girls and boys. As regards possible different impact of BED

and SBED on adolescents’ quality of life, one study64 has

evidenced that 62.6% of adolescents with BED and 34.6%

of adolescents with SBED reported impairment in the past

year, especially in the domains of social life and household

chore, respectively. About 9% of adolescents with BED had

severe impairments, particularly in social life, while 2.8% of

those with SBED reported severe school or work impairment.

Although the research design did not allow causal links, it

represented the first population-based study focused on the

impact of both threshold and subthreshold of BED in a large

population-based samples of female and male adolescents.

With specific regards to the effects on psychological

health, we have identified eight studies18,39,40,59–61,67,68 that

have underlined that BED in adolescence is associated with

various adverse mental health outcomes, especially anxiety

and depressive symptoms. Two studies61,67 have focused on

community sample groups of female adolescents, evidencing

a strong association between BED and depressive symptoms.

Moreover, in comparison with the other subtype of EDs, BED

was the only one illness predictive of depressive symptoms.61

A study by Skinner et al67 has shown that prospective asso-

ciations between binge eating and depressive symptomatol-

ogy had similar strength in both directions, suggesting the

presence of a bidirectional relationship between these two

psychopathological difficulties.

More recently, three studies39,59,68 have confirmed these

associations also for adolescent boys. One of them39 has

reported a higher power of prospective associations between

BED and depressive symptoms among boys. Moreover, these

studies have also evidenced an expanded range of adverse

psychological health outcomes predicted by BED, including

anxiety and stress symptoms, substance use, and a general

low quality of life. However, associations with stress and

anxiety symptoms had large effect size.68

Given that prevalence studies have underlined that SBED

is very frequent in adolescent population, we considered four

studies18,32,40,60 that have examined the impact of both BED

and SBED on psychological well-being. Two longitudinal

studies32,40 on female adolescent community sample have

reported that youths with both BED and SBED showed

higher mental health difficulties, functional impairment, and

emotional distress, than controls did, with no significant dif-

ferences between the two forms of disease respect to these

variables. Consistent with previous studies, a cross-sectional

study by Swanson et al18 on a community sample of adoles-

cent girls and boys found significant associations between

both BED and SBED with mood disorder, anxiety, alcohol,

and drug use, in female and male adolescents (aged 13–18

years). In this study, adolescents with BED showed more

difficulties in the area of anxiety, while those with SBED

Reference Age (years)

Sample (N)

Outcome Results (OR; 95% CI) or (p-value) or (Cohen’s d) or (%)

Stice et al32 15–23 496 Functional impairment Emotional distress Suicidality Mental health service utilization

BED was significantly associated with functional impairment (p<0.01; d=1.06), emotional distress (p<0.01; d=1.22), suicidality (p<0.01; d=1.14), and mental health treatment (p<0.01; d=1.10). SBED was associated only with emotional distress (p<0.01; d=0.94) and suicidality (p<0.01; d=0.51)

Forrest et al66

13–18 10,123 Suicidality BED was associated with elevated odds of suicidal ideation (OR: 3.81; CI: 2.14–6.77; p<0.001) and attempting (OR: 5.01; CI: 1.62–15.48; p<0.01)

Notes: aThreshold BED; bsubthreshold BED. Cohen’s d effect size: 0.20 = small, 0.50 = medium, and 0.80 = large. Abbreviations: BED, binge eating disorder; BMI, body mass index; CI, confidence interval; OR, odds ratio; SBED, subthreshold binge eating disorder.

Table 3 (Continued)

A

d o

le sc

e n

t H

e a

lth ,

M e

d ic

in e

a n

d T

h e

ra p

e u

tic s

d o

w n

lo a

d e

d f

ro m

h tt

p s:

// w

w w

.d o

ve p

re ss

.c o

m /

b y

1 7

4 .2

2 7

.3 .7

4 o

n 2

6 -O

ct -2

0 1

8 F

o r

p e

rs o

n a

l u se

o n

ly .

Powered by TCPDF (www.tcpdf.org)

1 / 1

Adolescent Health, Medicine and Therapeutics 2018:9submit your manuscript | www.dovepress.com Dovepress

Dovepress

24

Marzilli et al

were associated with a higher risk for alcohol and drug use.

Another study60 confirmed similar results even longitudinally,

reporting that the main significant associations were between

SBED and both anxiety and depressive symptoms.

Finally, given that research has underlined clinically

significant impairment of BED in adolescence, in terms of

physical and mental health difficulties, we considered four

studies18,32,60,66 that have also examined its possible impact on

suicidality (in terms of suicidal ideation, suicidal thoughts,

and suicidal attempts) or self-injury. Two studies18,32 found

significant associations between BED and SBED and suicid-

ality in female and male adolescents, with a higher effect size

for BED. Another study60 has evidenced that SBED, but not

BED, was prospectively significantly associated with delib-

erate self-harm. Finally, a recent study by Forrest et al66 has

reported that the majority of adolescents with BED reported

that suicidal ideation followed BED onset, suggesting that

binge eating might represent an important risk factor for

suicidality in adolescent population.

Psychological treatment strategies Despite the high prevalence of BED in adolescent populations

and the severe physical, social, and psychological associ-

ated outcomes, systematic studies on possible and effective

psychological treatment for BED among young population

are scarce.

Several psychological intervention options have been

studied for the treatment of BED in adulthood,69 such as 1)

cognitive behavioral therapy (CBT),70–72 which concentrates

on changing dysfunctional patterns of eating-related thinking

and behaviors; 2) behavioral weight loss treatment,73 which

are specifically focused on physical activity and modifying

diet to reduce overweight and obesity; 3) interpersonal psy-

chotherapy (IPT),69,75 a short-term psychotherapy focused on

reducing interpersonal difficulties associated with the onset

and/or maintenance of BED; and 4) dialectical behavior

therapy (DBT),76,77 which is directly focused on emotional

dysregulation and difficulties in coping with one’s own

emotions, by promoting the capacity to recognizing, tol-

erating, and regulating their emotions and mood states.78

Notwithstanding research has demonstrated their efficacy

in reducing binge eating in the short and long term, to date,

very few studies have examined the possible effectiveness

of these psychological interventions also in adolescents with

BED. In particular, we found only six studies79–84 that have

developmentally adapted these treatments to adolescent girls

and in small samples. Two of them79,80 have examined the

effectiveness of CBT, two81,82 are focused on IPT and the other

two83,84 have used DBT (Table 4). We found that no study has

focused on psychological intervention on male adolescents.

With regard to CBT studies, DeBar et al79 have used an

adolescent adaptation of CBT in a sample of female ado-

lescents with BED (52%), recurrent binge eating episodes

(32%), or bulimia spectrum disorders (16%). Subjects in

CBT group were compared with a usual-delayed treatment

(TAU-DT) control group (N=13), in which adolescents received CBT 6 months later. All participants were assessed

at baseline and at 3- and 6-month follow-up sessions. Female

adolescents in CBT group showed significantly higher absti-

nence of binge eating episodes at 3- and 6-month follow-up

than their peers of TAU-DT group, with a robust effect size.

At follow-up, totality of participants of CBT was abstinent.

Moreover, the intervention also produced significant improve-

ments in other shape-, weight-, and eating-related concerns,

although with a smaller effect size. Finally, girls in the CBT

group showed a significant lower depressive symptoms at

both the follow-up sessions. However, subjects of TAU-DT

group, who were additionally followed up at 9 and 13 months,

reported similar outcomes. Although this study provided

a preliminary evidence of the efficacy of CBT in reduc-

ing binge eating symptoms and their secondary outcomes

among adolescent population, homogeneity and small size

of sample did not permit generalizability of these findings.

Another study by Jones et al80 has investigated the use of

an Internet-facilitated CBT-self-help intervention along

16 weeks, compared to a 9-month-wait-list control (WLC)

group, for weight maintenance and the reduction of binge

eating episodes. In particular, the treatment program was

composed by an integrated intervention in which behavioral

weight loss (BWL) was combined with CBT. This choice was

due to the evidence that in adolescence the specific increased

focus on body weight, control of eating behaviors, and

dietary that characterizes traditional weight loss programs73

could produce the paradoxical effect of increasing the risk

and/or severity of ED symptomatology.85 Moreover, despite

traditional BWL programs being found to be effective in the

treatment of BED in adults,74 they are specifically focused

on the objective overeating episodes, neglecting the aspects

of loss of control which are particularly central in BED in

adolescence.37 Subjects in CBT group showed significantly

lower BMI and BMI z scores at follow-up assessment, a

greater decrease in both objective and subjective binge epi-

sodes at both posttreatment and follow-up assessments, and

a significant reduction of weight- and shape-related concerns

than control did, supporting the effectiveness of this interven-

tion also in female adolescents with BED.

A

d o

le sc

e n

t H

e a

lth ,

M e

d ic

in e

a n

d T

h e

ra p

e u

tic s

d o

w n

lo a

d e

d f

ro m

h tt

p s:

// w

w w

.d o

ve p

re ss

.c o

m /

b y

1 7

4 .2

2 7

.3 .7

4 o

n 2

6 -O

ct -2

0 1

8 F

o r

p e

rs o

n a

l u se

o n

ly .

Powered by TCPDF (www.tcpdf.org)

1 / 1

Adolescent Health, Medicine and Therapeutics 2018:9 submit your manuscript | www.dovepress.com Dovepress

Dovepress

25

Binge eating disorder in adolescence

Regarding IPT that has been suggested to be an important

strategy to reduce binge eating and associated interpersonal

problems,69 we found only two studies81,82 that evaluated

its effectiveness in adolescents with BED. A pilot study by

Tanofsky-Kraff et al81 focused on IPT in a sample of female

adolescents who were at-risk for excessive weight gain, with

and without LOC eating, and reported a significant reduction

in LOC episodes at 6-month follow-up and in BMI over 1

year, compared with girls randomly assigned to a standard-

of-care health education (HE) program group. However, as

in most pilot studies, the absence of statistical power did not

allow generalizable conclusions on the reported effectiveness.

Consequently, more recently, the same authors82 conducted an

adequately powered clinical trial to verify the effectiveness

of an adapted IPT group of girls compared to an HE control

group. Adolescents of both the groups reported significant

reduction of dimensions of BMI (expected BMI gain, BMI

z score, and BMI percentile), anxiety and depressive symp-

tomatology, and LOC episodes over 1-year follow-up, with

no differences between groups. However, girls in IPT group

have shown a significant decrease of binge eating episodes

at 12-month follow-up.

Finally, we reported two studies83,84 specifically interested

in examining the effectiveness of DBT in reducing binge

eating symptoms. One of them, Safer et al’s study,83 was

a case report of a 16-year-old girl, who has shown a sig-

nificant reduction of binge eating episodes after treatment,

and abstinence from binging at 3-month follow-up. Despite

potential limitations of case–control studies, we considered

this study because it provided a preliminary support for the

utility of the adolescent modified version of DBT in reducing

binge eating episodes. Finally, Mazzeo et al84 examined the

effectiveness of DBT in adolescent girls, compared to a BWL

treatment control group, reporting a significant reduction

Table 4 Psychological treatment studies for adolescents with BED

Reference Age (years)

Psychological treatment

Control group Sample (N) Results (OR: 95% CI) or (p-value) or (Cohen’s d) or (%)

EG CG

DeBar et al79 12–18 CBT (8 sessions over 6 months)

TAU-DT 13 12 CBT participants had a significant higher rate of abstinence from recurrent binge eating at 3 months (p<0.01) and at 6 months (p<0.01; d=1.467), a significant greater improvement in eating-related concerns (p<0.05; d=0.80), shape-related concerns (p<0.01; d=1.04), and weight-related concerns (p<0.01; d=0.64) and significant higher reduction in depressive symptoms (p=0.051; d=0.57) at both 3 and 6 months

Jones et al80 15 Internet-facilitated CBT-self-help intervention (16 session over 16 weeks)

WLC 52 53 Internet-facilitated CBT-self-help intervention was associated with a significant reduction of BMI z scores (p<0.01; d=0.80) and BMI (p<0.01; d=0.60) at 9-month follow-up assessment, a significant decrease of objective and subjective binge episodes at both posttreatment assessment (p<0.01) and follow-up assessment (p<0.05) and a significant lower weight- and shape- related concerns (p<0.05)

Tanofsky- Kraff et al81

12–17 IPT (12 sessions over 12 weeks)

HE 19 19 IPT was associated with significant reduction in LOC episodes at 6-month follow-up (p<0.05) and in BMI (p<0.05) over 1 year

Tanofsky- Kraff et al82

12–17 IPT (12 sessions over 12 weeks)

HE 56 60 Both IPT and HE were associated with a significant decrease in expected BMI gain (p<0.001), BMI z score (p=0.003), BMI percentile (p<0.001), anxiety and depressive symptoms (p<0.001), and the frequency of LOC episodes (p<0.001) over 12-month follow-up. IPT was associated with a significant higher reduction of objective binge eating (p<0.05) at the 12-month follow-up

Safer et al83 16 DBT (30 sessions over 6 months)

None 1 0 DBT was associated with decreased binge eating episodes by the end of treatment and abstinence at 3-month follow-up

Mazzeo et al84 13–17 DBT (12 sessions over 12 weeks)

BWT 28 17 DBT and BWT were associated with significant reductions in eating-related concern (p<0.05), shape-related concern (p<0.05), restraint (p<0.05), global disordered eating attitudes (p<0.05), and negative (p<0.05) effect

Notes: Cohen’s d effect size: 0.20 = small, 0.50 = medium, and 0.80 = large. Abbreviations: BET, binge eating disorder; BMI, body mass index; BWT, behavioral weight loss treatment; CBT, cognitive behavioral therapy; CG, control group; CI, confidence interval; DBT, dialectical behavior therapy; EG, experimental group; HE, health education; IPT, interpersonal psychotherapy; LOC, loss of control; OR, odds ratio; TAU-DT, treatment as usual-delayed treatment; WLC, wait-list control.

A

d o

le sc

e n

t H

e a

lth ,

M e

d ic

in e

a n

d T

h e

ra p

e u

tic s

d o

w n

lo a

d e

d f

ro m

h tt

p s:

// w

w w

.d o

ve p

re ss

.c o

m /

b y

1 7

4 .2

2 7

.3 .7

4 o

n 2

6 -O

ct -2

0 1

8 F

o r

p e

rs o

n a

l u se

o n

ly .

Powered by TCPDF (www.tcpdf.org)

1 / 1

Adolescent Health, Medicine and Therapeutics 2018:9submit your manuscript | www.dovepress.com Dovepress

Dovepress

26

Marzilli et al

in eating-related concern, shape-related concern, restraint,

global disordered eating attitudes, and negative effect in

both the groups.

Summary What is the prevalence of BED in adolescence? BED has only recently been introduced into the psychiatric

nomenclature, and consequently, epidemiological research

of this ED in adolescence is in the early stages. Prevalence

rate for BED was reported in 13 studies, five of them18,40,51–53

using DSM-IV criteria and eight of them10,31,32,39,59–62 using the

DSM-5 criteria. Altogether, our review of the literature on the

prevalence of BED has shown that this disorder is very com-

mon in adolescence phase, with a rate approximately ranging

from 1% to 5%. Moreover, one study18 has also examined the

incidence of BED in female adolescent populations, reporting

a rate of 343 per 100,000 persons.

Although most studies have been conducted with the

samples of teenage girls, nine studies10,18,31,39,51–53,59,60 have

focused on both the sexes, reporting significant sex-related

differences. In particular, girls showed a higher risk for BED

than boys (1%–4%; 0%–1.2%, respectively).31,39,52,53,57 How-

ever, this sex-related difference was less pronounced in other

EDs.86 For this reason, BED represents the most common ED

among male adolescent population.87 Moreover, longitudinal

studies that we reviewed have evidenced that the prevalence

of BED tended to increase over time, with a peak at 19–22

years of age for female adolescents39,61 and at 24 years for

male adolescents.39

Interestingly, it has been evidenced that in adoles-

cents, BED frequently manifests in attenuated, sub-

clinical forms.18,38,39 Indeed, studies with subthreshold

adolescents10,18,32,40,60 found a twofold BED prevalence. More-

over, the prevalence in male adolescents was lower than that

in female adolescents also with respect to SBED diagnoses,

with 0.3%–4.6% in girls and 0%–2.3% in boys.10,18,60

However, the validity of some of the reviewed studies can

be questioned, because the prevalence rate and the definition

itself of binge eating may differ depending on the assessment

measurements used by researchers. In particular, studies that

have used self-report assessments52,53,59,61 tended to report

higher prevalence than interview-based studies.10,18,31,32,39,40,62

This may depend on the fact that interviews may allow

clarifying the subjective experience of “lack of control

overeating” and objectively measure the “large food con-

sumption,” which represent two key criteria for the clinical

diagnosis of BED. Other specific problems are the general

tendency of individuals suffering from BED to hide their ill-

ness, the limited awareness of the clinical relevance of their

disordered eating, and, consequently, the difficulty to seek

for professional help.18,88 For these reasons, future studies

on large sample of adolescents from the general population

are needed.

What are the physical, social, and psychological outcomes of BED in adolescence? Research in the last decade has documented the clinical

significance of BED in terms of adverse physical, social,

and psychological health problems commonly associated

with this condition. In particular, with regard to physical

outcomes, several studies have reported that BED and SBED,

in both female and male adolescents, were predictive of high

rates of overweight and obesity.39,60,61,64 This finding supports

the view of clinical significance of binge eating, given the

important consequences on health associated with obesity

in adolescent and adult populations. Indeed, international

research has evidenced that obesity is associated with an

increased risk to develop severe medical conditions, such as

type II diabetes mellitus (DM), hypertension, cardiovascular

disease, fatty liver disease, and a higher risk for morbidity

and mortality.89

However, many studies have underlined that the impact

of BED leads to an increased risk of developing a variety

of adverse social and emotional-behavioral outcomes, in

both obese and population-based adolescent samples.18,65 In

particular, the cross-sectional and prospective studies that we

considered here have evidenced that both BED and SBED

significantly affect health-related quality of life, with marked

impairment especially in social and family relationships,

and are also associated with negative self-esteem.64,65 More

specifically, adolescents with BED tended to show more

difficulties in social/interpersonal functioning and work/

school achievements, while SBED was strongly associated

especially with lower quality of general daily living and

family burden.18,39,40,59–61,67,68 Although these consequences

of binge eating may be similar for both female and male

adolescents, female adolescents reported the highest levels

of impairment.18,64,65

Moreover, the studies we reviewed have also evidenced

a growing interest in examining possible associations of

BED with psychiatric comorbidities. These studies have

evidenced that BED in adolescence is a strong predictor of

a large spectrum of mental health difficulties. Most of them

showed prospective associations with internalizing problems,

A

d o

le sc

e n

t H

e a

lth ,

M e

d ic

in e

a n

d T

h e

ra p

e u

tic s

d o

w n

lo a

d e

d f

ro m

h tt

p s:

// w

w w

.d o

ve p

re ss

.c o

m /

b y

1 7

4 .2

2 7

.3 .7

4 o

n 2

6 -O

ct -2

0 1

8 F

o r

p e

rs o

n a

l u se

o n

ly .

Powered by TCPDF (www.tcpdf.org)

1 / 1

Adolescent Health, Medicine and Therapeutics 2018:9 submit your manuscript | www.dovepress.com Dovepress

Dovepress

27

Binge eating disorder in adolescence

especially depressive (reported by ~45% of subjects with BED), anxiety, and distress symptoms (as displayed by about

one third of adolescents with BED),18,59–61,64,65,67 and suggest-

ing a higher impact on male adolescents.39 Substance use

also seems to affect one fourth of subjects with BED.18,39,60

Finally, a few studies have also examined the possible

impact of BED on suicidality.18,32,60,66 To date, research in this

field is scarce, but some studies suggested that adolescents

with either BED or SBED, as well as other EDs,90 had a

higher risk of suicidal ideation and attempts than non-eating-

disordered youths. In particular, suicidal ideation is found in

~30% adolescents with BED and 20% with SBED, and the frequency of suicidal attempts was 15.1% and 5.3%, respec-

tively.18,32,66 The presence of several self-harm behaviors

among BED adolescents has also been evidenced.60 More-

over, although BED is found to co-occur with several mental

disorders that are known to increase mortality risks,91,92 to our

knowledge no study has so far been published to systemati-

cally examine the effects of BED on mortality.

What is the effectiveness of existing psychological interventions for BED in the adolescent population? To date, evidence for effective treatments for adolescents with

BED is growing but yet scarce and inconsistent. This may be

due to the fact that BED has only recently been included as a

diagnostic category in DSM-5, and, consequently, attention of

clinicians on specific intervention in this area is at its dawn.

However, as our review has shown, in the last decade,

researchers and clinicians have developmentally adapted

some of the intervention approaches that proved effective

for the treatment of BED in adult samples.67–73 In particular,

we have identified some small trials of CBT,79,80 IPT,81,82 and

DBT83,84 involving adolescents and young adults with BED.

In accordance with the NICE guidelines,93 CBT is recom-

mended to be the standard treatment for adult subjects suffer-

ing from BED, and our review has confirmed its effectiveness

in reducing binge eating symptoms and the severity of risk

factors also among adolescent population.79 Moreover, it has

also been evidenced that Internet-based CBT interventions80

can provide a valid support, especially in the early phase of

the syndrome. Furthermore, online interventions have been

shown to have many advantages for their accessibility, due

to the reduced cost and time required, and they may also

facilitate adolescent help-seeking. Also the few studies that

have used adolescent-adapted IPT81,82 and DBT83,84 have

reported findings that seem promising in reducing both binge

eating problems and co-occurring mental health symptoms.

Interestingly, some interventions have also favored weight

loss or a weight maintenance. Given that adult population

with BED has been evidenced that overweight typically fol-

lowed the onset of binge BED,94 previous findings underlined

that an early identification and intervention on binge eating

in adolescence may reduce the risk of excessive weight gain

and, thus, help to prevent adult obesity.

Notwithstanding the studies we reviewed have evidenced

some positive preliminary results in reducing binge eating

episodes and associated psychopathological symptoms, all

of them had small sample size and relatively short follow-up

intervals, precluding definitive conclusions about their effec-

tiveness and appropriateness, and suggesting the necessity

of implementing long-term longitudinal studies to verify

the persistence of clinical benefits over time. Furthermore,

additional research comparing these different methodological

interventions is needed.

Moreover, to the best of our knowledge, no study has yet

been conducted to confirm the effectiveness of psychological

treatment in male adolescents with BED.

Finally, it is important to emphasize that epidemiologi-

cal studies have suggested that only a small percentage of

adolescents with BED (specifically, 11.9%) tended to seek

clinical help.18 Moreover, the high rate of adolescents who

do not meet full-threshold criteria, although they are affected

by various severe physical and psychological negative conse-

quences, makes it even harder to identify them, suggesting the

importance of implementing primary prevention programs

aimed at increasing awareness, reducing stigma, and promot-

ing acceptance of intervention.

Conclusion International research has underlined that adolescence is

characterized by a high risk for the onset of BED, which

represents the most common ED subtype among youths,

posing severe risks to their physical and mental health. Sev-

eral studies have evidenced the complex etiopathogenesis

of BED, which seems to result from dynamic and reciprocal

relationships between different type of variables, including

biological (in particular, familial genetic predisposition and

epigenetic processes),95,96 psychological (such as personal-

ity traits of perfectionism and impulsivity, negative effect

or depressive symptoms, weight and eating concerns, and

body dissatisfaction),98–100 and environmental risk factors, in

terms of parental influences on childhood eating behavior,95

parental psychopathology and psychopathological risk,101

early adverse experiences, and the presence of traumatic

experiences in the parents.102 Among individual risk factor,

A

d o

le sc

e n

t H

e a

lth ,

M e

d ic

in e

a n

d T

h e

ra p

e u

tic s

d o

w n

lo a

d e

d f

ro m

h tt

p s:

// w

w w

.d o

ve p

re ss

.c o

m /

b y

1 7

4 .2

2 7

.3 .7

4 o

n 2

6 -O

ct -2

0 1

8 F

o r

p e

rs o

n a

l u se

o n

ly .

Powered by TCPDF (www.tcpdf.org)

1 / 1

Adolescent Health, Medicine and Therapeutics 2018:9submit your manuscript | www.dovepress.com Dovepress

Dovepress

28

Marzilli et al

it has also been reported that dietary restraint, a general rigid

eating habits and maladaptive weight control behaviors repre-

sent significant risk factor for the onset of BED.103 Moreover,

many studies have reported the predictive role played by peer

influences and perception of a lack of peer support,104,105 as

well as by cultural influences (especially social pressure for

thinness and the resulting body dissatisfaction)97,106 on the

onset of BED. Overall, these findings suggest the impor-

tance of implementing longitudinal studies and randomized

controlled trials to increase our knowledge of long-term

outcomes of BED and support the planning of evidence-based

prevention programs and treatment strategies targeted on the

risk factors for the onset and maintenance of BED. Given

the high prevalence of adolescents who reported SBED,

early detection is needed in order to prevent the evolution

and worsening of eating symptoms. Moreover, although it

has been underlined that a high prevalence of BED may also

be found in male adolescent population, there is a dearth of

studies that have specifically focused on the possible effec-

tiveness of intervention programs in boys with BED. Thus,

future studies including both female and male adolescents

with BED are needed.

Disclosure The authors report no conflicts of interest in this work.

References 1. Striegel-Moore RH, Franko DL. Should binge eating disorder be

included in the DSM-V? A critical review of the state of the evidence. Annu Rev Clin Psychol. 2008;4:305–324.

2. Eddy KT, Crosby RD, Keel PK, et al. Empirical identification and validation of eating disorder phenotypes in a multisite clinical sample. J Nerv Ment Dis. 2009;197(1):41–49.

3. Grilo CM, Ivezaj V, White MA. Evaluation of the DSM-5 severity indicator for binge eating disorder in a clinical sample. Behav Res Ther. 2015;71:110–114.

4. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (DSM-5). Washington, DC: American Psychiatric Association; 2013.

5. Hilbert A, Pike KM, Wilfley DE, Fairburn CG, Dohm FA, Striegel- Moore RH. Clarifying boundaries of binge eating disorder and psychiatric comorbidity: a latent structure analysis. Behav Res Ther. 2011;49(3):202–211.

6. Sysko R, Roberto CA, Barnes RD, Grilo CM, Attia E, Walsh BT. Test– retest reliability of the proposed DSM-5 eating disorder diagnostic criteria. Psychiatry Res. 2012;196(2):302–308.

7. Kessler RC, Berglund PA, Chiu WT, et al. The prevalence and corre- lates of binge eating disorder in the World Health Organization World Mental Health Surveys. Biol Psychiatry. 2013;73(9):904–914.

8. Kessler RC, Shahly V, Hudson JI, et al. A comparative analysis of role attainment and impairment in binge-eating disorder and bulimia ner- vosa: results from the WHO World Mental Health Surveys. Epidemiol Psychiatr Sci. 2014;23(1):27–41.

9. American Psychiatric Association. Diagnostic Criteria from DSM-IV- TR. Washington, DC: American Psychiatric Association; 2000.

10. Lee-Winn AE, Reinblatt SP, Mojtabai R, Mendelson T. Gender and racial/ethnic differences in binge eating symptoms in a nationally representative sample of adolescents in the United States. Eat Behav. 2016;22:27–33.

11. Schag K, Schönleber J, Teufel M, Zipfel S, Giel KE. Food-related impulsivity in obesity and Binge Eating Disorder – a systematic review. Obes Rev. 2013;14(6):477–495.

12. Barry DT, Grilo CM, Masheb RM. Gender differences in patients with binge eating disorder. Int J Eat Disord. 2002;31(1):63–70.

13. Masheb RM, Grilo CM. Emotional overeating and its asso- ciations with eating disorder psychopathology among overweight patients with binge eating disorder. Int J Eat Disord. 2006;39(2): 141–146.

14. Stein RI, Kenardy J, Wiseman CV, Dounchis JZ, Arnow BA, Wilfley DE. What’s driving the binge in binge eating disorder? A prospec- tive examination of precursors and consequences. Int J Eat Disord. 2007;40(3):195–203.

15. Gonzalez A, Kohn M, Clarke S. Eating disorders in adolescents. Aust Fam Physician. 2007;36(8):614.

16. Ágh T, Kovács G, Pawaskar M, Supina D, Inotai A, Vokó Z. Epide- miology, health-related quality of life and economic burden of binge eating disorder: a systematic literature review. Eat Weight Disord. 2015;20(1):1–12.

17. Nicholls D, Barrett E. Eating disorders in children and adolescents. BJPsych Adv. 2015;21(3):206–216.

18. Swanson SA, Crow SJ, Le Grange D, Swendsen J, Merikangas KR. Prevalence and correlates of eating disorders in adolescents: results from the national comorbidity survey replication adolescent supple- ment. Arch Gen Psychiatry. 2011;68(7):714–723.

19. Paciello M, Fida R, Tramontano C, Cole E, Cerniglia L. Moral dilemma in adolescence: the role of values, prosocial moral reasoning and moral disengagement in helping decision making. Eur J Dev Psychol. 2013;10(2):190–205.

20. Anderson, NK, Nicolay OF. Eating disorders in children and adoles- cents. Semin Orthod. 2016;22(3):234–237.

21. Cerniglia L, Cimino S, Ballarotto G, Tambelli R. Do parental trau- matic experiences have a role in the psychological functioning of early adolescents with binge eating disorder? Eat Weight Disord. 2016;21(4):635–644.

22. Patel P, Wheatcroft R, Park RJ, Stein A. The children of mothers with eating disorders. Clin Child Fam Psychol Rev. 2002;5:1–19.

23. Wu M, Lu LH, Lowes A, et al. Development of superficial white matter and its structural interplay with cortical gray matter in children and adolescents. Hum Brain Mapp. 2014;35(6):2806–2816.

24. Bray S, Krongold M, Cooper C, Lebel C. Synergistic effects of age on patterns of white and gray matter volume across childhood and adolescence. eNeuro. 2015;2(4):3–15.

25. Gondoli DM, Corning AF, Salafia EHB, Bucchianeri MM, Fitzsim- mons EE. Heterosocial involvement, peer pressure for thinness, and body dissatisfaction among young adolescent girls. Body Image. 2011;8(2):143–148.

26. Rajagopalan J, Shejwal B. Influence of sociocultural pressures on body image dissatisfaction. Psychol Stud. 2014;59(4):357–364.

27. Cerniglia L, Cimino S, Ballarotto G, et al. Motor vehicle accidents and adolescents: an empirical study on their emotional and behavioural profiles, defense strategies and parental support. Transp Res Part F Traffic Psychol Behav. 2015;35:28–36.

28. Shapiro-Weiss G, Shapiro-Weiss J. Recent advances in child psychia- try: eating disorders common in high school students. Psychiatric Guide. 2001;8:13.

29. Poppe I, Simons A, Glazemakers I, Van West D. Early-onset eating disorders: a review of the literature. Tijdschr Psychiatr. 2015;57(11):805–814.

30. Preti A, de Girolamo G, Vilagut G, et al. The epidemiology of eating disorders in six European countries: results of the ESEMeD-WMH project. J Psychiatr Res. 2009;43(14):1125–1132.

A

d o

le sc

e n

t H

e a

lth ,

M e

d ic

in e

a n

d T

h e

ra p

e u

tic s

d o

w n

lo a

d e

d f

ro m

h tt

p s:

// w

w w

.d o

ve p

re ss

.c o

m /

b y

1 7

4 .2

2 7

.3 .7

4 o

n 2

6 -O

ct -2

0 1

8 F

o r

p e

rs o

n a

l u se

o n

ly .

Powered by TCPDF (www.tcpdf.org)

1 / 1

Adolescent Health, Medicine and Therapeutics 2018:9 submit your manuscript | www.dovepress.com Dovepress

Dovepress

29

Binge eating disorder in adolescence

31. Smink FR, van Hoeken D, Oldehinkel AJ, Hoek HW. Prevalence and severity of DSM-5 eating disorders in a community cohort of adoles- cents. Int J Eat Disord. 2014;47(6):610–619.

32. Stice E, Marti CN, Rohde P. Prevalence, incidence, impairment, and course of the proposed DSM-5 eating disorder diagnoses in an 8-year prospective community study of young women. J Abnorm Psychol. 2013;122(2):445–457.

33. Croll J, Neumark-Sztainer D, Story M, Ireland M. Prevalence and risk and protective factors related to disordered eating behaviors among adolescents: relationship to gender and ethnicity. J Adolesc Health. 2002;31(2):166–175.

34. Tanofsky-Kraff M, Shomaker LB, Olsen C, et al. A prospective study of pediatric loss of control eating and psychological outcomes. J Abnorm Psychol. 2011;120(1):108.

35. Goldschmidt AB, Wall MM, Loth KA, Bucchianeri MM, Neumark- Sztainer D. The course of binge eating from adolescence to young adulthood. Health Psychol. 2014;33(5):457–460.

36. Herpertz-Dahlmann B. Adolescent eating disorders: update on defini- tions, symptomatology, epidemiology, and comorbidity. Child Adolesc Psychiatr Clin N Am. 2015;24(1):177–196.

37. Tanofsky-Kraff M, Marcus MD, Yanovski SZ, Yanovski JA. Loss of control eating disorder in children age 12 years and younger: proposed research criteria. Eat Behav. 2008;9(3):360–365.

38. Swanson SA, Aloisio KM, Horton NJ, et al. Assessing eating disorder symptoms in adolescence: is there a role for multiple informants? Int J Eat Disord. 2014;47(5):475–482.

39. Sonneville KR, Horton NJ, Micali N, et al. Longitudinal associations between binge eating and overeating and adverse outcomes among adolescents and young adults: does loss of control matter? JAMA Pediatr. 2013;167(2):149–155.

40. Stice E, Marti CN, Shaw H, Jaconis M. An 8-year longitudinal study of the natural history of threshold, subthreshold, and partial eating disorders from a community sample of adolescents. J Abnorm Psychol. 2009;118(3):587–597.

41. Lewinsohn PM, Seeley JR, Moerk KC, Striegel-Moore RH. Gender differences in eating disorder symptoms in young adults. Int J Eat Disord. 2002;32(4):426–440.

42. Striegel-Moore RH, Rosselli F, Perrin N, et al. Gender difference in the prevalence of eating disorder symptoms. Int J Eat Disord. 2009;42(5):471–474.

43. Wilfley DE, Wilson GT, Agras WS. The clinical significance of binge eating disorder. Int J Eat Disord. 2003;34(1):96–106.

44. Whisman MA, Dementyeva A, Baucom DH, Bulik CM. Marital functioning and binge eating disorder in married women. Int J Eat Disord. 2012;45(3):385–389.

45. Green BN, Johnson CD, Adams A. Writing narrative literature reviews for peer-reviewed journals: secrets of the trade. J Chiropr Med. 2006;5:10117.

46. Pan L. Preparing Literature Reviews: Qualitative and Quantitative approaches. 3rd ed. Glendale, CA: Pyrczak Publishing; 2008.

47. Ferrari R. Writing narrative style literature reviews. Medical Writing. 2015;24(4):230–235.

48. Grant MJ, Booth A. A typology of reviews: an analysis of 14 review types and associated methodologies. Health Info Libr J. 2009;26:91–108.

49. Egger M, Smith GD, Altman DG. Systematic Reviews in Health Care: Meta-Analysis in Context. London, UK: BMJ Publishing Group; 2001.

50. American Academy of Child and Adolescent Psychiatry. Facts for Families. Washington, DC: American Academy of Child and Adoles- cent Psychiatry; 2011.

51. Decaluwé V, Braet C. Prevalence of binge-eating disorder in obese children and adolescents seeking weight-loss treatment. Int J Obes Relat Metab Disord. 2003;27(3):404–409.

52. Kjelsås E, Bjørnstrøm C, Götestam KG. Prevalence of eating dis- orders in female and male adolescents (14–15 years). Eat Behav. 2004;5(1):13–25.

53. Ackard DM, Fulkerson JA, Neumark-Sztainer D. Prevalence and utility of DSM-IV eating disorder diagnostic criteria among youth. Int J Eat Disord. 2007;40(5):409–417.

54. Walsh BT. Report of the DSM-5 Eating Disorders Work Group. Wash- ington, DC: American Psychiatric Association DSM-5 Development; 2009.

55. Fairburn CG, Beglin SJ. Assessment of eating disorders: interview or self-report questionnaire? Int J Eat Disord. 1994;16:363–370.

56. Turner H, Bryant-Waugh R. Eating disorder not otherwise specified (EDNOS): profiles of clients presenting at a community eating disorder service. Eur Eat Disord Rev. 2004;12:18–26.

57. Machado PPP, Goncalves S, Hoek HW. DSM-5 reduces the propor- tion of EDNOS cases: evidence from community samples. Int J Eat Disord. 2013;46:60–65.

58. Wade TD, Bergin JL, Tiggemann M, Bulik CM, Fairburn CG. Preva- lence and long-term course of lifetime eating disorders in an adult Australian twin cohort. Aust N Z J Psychiatry. 2006;40:121–128.

59. Allen KL, Byrne SM, Oddy WH, Crosby RD. DSM-IV-TR and DSM-5 eating disorders in adolescents: prevalence, stability, and psychosocial correlates in a population-based sample of male and female adoles- cents. J Abnorm Psychol. 2013;122(3):720.

60. Micali N, Solmi F, Horton NJ, et al. Adolescent eating disorders predict psychiatric, high-risk behaviors and weight outcomes in young adult- hood. J Am Acad Child Adolesc Psychiatry. 2015;54(8):652–659.

61. Field AE, Sonneville KR, Micali N, et al. Prospective association of common eating disorders and adverse outcomes. Pediatrics. 2012;130(2):e289–e295.

62. Crow SJ, Swanson SA, le Grange D, Feig EH, Merikangas KR. Sui- cidal behavior in adolescents and adults with bulimia nervosa. Compr Psychiatry. 2014;55(7):1534–1539.

63. Tabler J, Utz RL. The influence of adolescent eating disorders or disordered eating behaviors on socioeconomic achievement in early adulthood. Int J Eat Disord. 2015;48(6):622–632.

64. Micali N, Ploubidis G, De Stavola B, Simonoff E, Treasure J. Fre- quency and patterns of eating disorder symptoms in early adolescence. J Adolesc Health. 2014;54(5):574–581.

65. Ranzenhofer LM., Columbo KM, Tanofsky-Kraff M, et al. Binge eat- ing and weight-related quality of life in obese adolescents. Nutrients. 2012;4(3):167–180.

66. Forrest LN, Zuromski KL, Dodd DR, Smith AR. Suicidality in adoles- cents and adults with binge-eating disorder: results from the national comorbidity survey replication and adolescent supplement. Int J Eat Disord. 2017;50(1):40–49.

67. Skinner HH, Haines J, Austin SB, Field AE. A prospective study of overeating, binge eating, and depressive symptoms among adolescent and young adult women. J Adolesc Health. 2012;50(5):478–483.

68. Allen KL, Byrne SM, Oddy WH, Crosby RD. Early onset binge eating and purging eating disorders: course and outcome in a population-based study of adolescents. J Abnorm Child Psychol. 2013;41(7):1083–1096.

69. Wilson GT, Wilfley DE, Agras WS. Psychological treatments of binge eating disorder. Arch Gen Psychiatry. 2010;67(1):94–101.

70. Grilo CM, Masheb RM, Wilson GT. Efficacy of cognitive behavioral therapy and fluoxetine for the treatment of binge eating disorder: a randomized double-blind placebo-controlled comparison. Biol Psy- chiatry. 2005;57(3):301–309.

71. Wilson GT, Fairburn CC, Agras WS, Walsh BT, Kraemer H. Cognitive- behavioral therapy for bulimia nervosa: time course and mechanisms of change. J Consult Clin Psychol. 2002;70(2):267–274.

72. Agras WS., Fitzsimmons-Craft EE, Wilfley DE. Evolution of cognitive-behavioral therapy for eating disorders. Behav Res Ther. 2017;88:26–36.

73. Grilo CM, Masheb RM, Wilson GT, Gueorguieva R, White MA. Cognitive–behavioral therapy, behavioral weight loss, and sequential treatment for obese patients with binge-eating disorder: a randomized controlled trial. J Consult Clin Psychol. 2011;79(5):675–685.

A

d o

le sc

e n

t H

e a

lth ,

M e

d ic

in e

a n

d T

h e

ra p

e u

tic s

d o

w n

lo a

d e

d f

ro m

h tt

p s:

// w

w w

.d o

ve p

re ss

.c o

m /

b y

1 7

4 .2

2 7

.3 .7

4 o

n 2

6 -O

ct -2

0 1

8 F

o r

p e

rs o

n a

l u se

o n

ly .

Powered by TCPDF (www.tcpdf.org)

1 / 1

Adolescent Health, Medicine and Therapeutics 2018:9submit your manuscript | www.dovepress.com Dovepress

Dovepress

Adolescent Health, Medicine and Therapeutics

Publish your work in this journal

Submit your manuscript here: http://www.dovepress.com/adolescent-health-medicine-and-therapeutics-journal

Adolescent Health, Medicine and Therapeutics is an international, peer-reviewed, open access journal focusing on health, pathology, and treatment issues specific to the adolescent age group. All aspects of health maintenance, preventative measures and disease treatment interventions are addressed within the journal and practitioners from all disciplines are

invited to submit their work as well as healthcare researchers and patient support groups. This journal is included in PubMed. The manuscript management system is completely online and includes a very quick and fair peer-review system. Visit http://www.dovepress.com/testimonials. php to read real quotes from published authors.

Dovepress

30

Marzilli et al

74. Munsch S, Meyer AH, Biedert E. Efficacy and predictors of long-term treatment success for cognitive-behavioral treatment and behavioral weight-loss-treatment in overweight individuals with binge eating disorder. Behav Res Ther. 2012;50(12):775–785.

75. Rieger E, Van Buren DJ, Bishop M, et al. An eating disorder-specific model of interpersonal psychotherapy (IPT-ED): causal pathways and treatment implications. Clin Psychol Rev. 2010;30(4):400–410.

76. Safer DL, Telch CF, Chen EY. Dialectical Behavior Therapy for Binge Eating and Bulimia. New York: Guilford Press; 2009.

77. Klein AS, Skinner JB, Hawley KM. Targeting binge eating through components of dialectical behavior therapy: preliminary outcomes for individually supported diary card self-monitoring versus group-based DBT. Psychotherapy. 2013;50(4):543–552.

78. Wiser S, Telch CF. Dialectical behavior therapy for binge-eating disorder. J Clin Psychol. 1999;55(6):755–768.

79. DeBar LL, Wilson GT, Yarborough BJ, et al. Cognitive behavioral treatment for recurrent binge eating in adolescent girls: a pilot trial. Cogn Behav Pract. 2013;20(2):147–161.

80. Jones M, Luce KH, Osborne MI, et al. Randomized, controlled trial of an internet-facilitated intervention for reducing binge eating and overweight in adolescents. Pediatrics. 2008;121(3):453–462.

81. Tanofsky-Kraff M, Wilfley DE, Young JF, et al. A pilot study of inter- personal psychotherapy for preventing excess weight gain in adolescent girls at-risk for obesity. Int J Eat Disord. 2010;43(8):701–706.

82. Tanofsky-Kraff M, Shomaker LB, Wilfley DE, et al. Targeted prevention of excess weight gain and eating disorders in high-risk adolescent girls: a randomized controlled trial. Am J Clin Nutr. 2014;100(4):1010–1018.

83. Safer DL, Couturier JL, Lock J. Dialectical behavior therapy modified for adolescent binge eating disorder: a case report. Cogn Behav Pract. 2007;14(2):157–167.

84. Mazzeo SE, Lydecker J, Harney M, et al. Development and preliminary effectiveness of an innovative treatment for binge eating in racially diverse adolescent girls. Eat Behav. 2016;22:199–205.

85. Cooper Z, Fairburn CG. A new cognitive behavioural approach to the treatment of obesity. Behav Res Ther. 2001;39(5):499–511.

86. Nagl M, Jacobi C, Paul M, et al. Prevalence, incidence, and natural course of anorexia and bulimia nervosa among adolescents and young adults. Eur Child Adolesc Psychiatry. 2016;25(8):903–918.

87. Smink FR, Van Hoeken D, Hoek, HW. Epidemiology of eating disor- ders: incidence, prevalence and mortality rates. Curr Psychiatry Rep. 2012;14(4):406–414.

88. Herpertz-Dahlmann B. Adolescent eating disorders: update on defini- tions, symptomatology, epidemiology, and comorbidity. Child Adolesc Psychiatr Clin N Am. 2015;24(1):177–196.

89. Reilly JJ, Methven E, McDowell ZC, et al. Health consequences of obesity. Arch Dis Child. 2003;88(9):748–752.

90. Kostro K, Lerman JB, Attia E. The current status of suicide and self-injury in eating disorders: a narrative review. J Eat Disord. 2014;2(1):19.

91. Chesney E, Goodwin GM, Fazel S. Risks of all-cause and suicide mor- tality in mental disorders: a meta-review. World Psychiatry. 2014;13(2): 153–160.

92. Coughlan H, Tiedt L, Clarke M, et al. Prevalence of DSM-IV mental disorders, deliberate self-harm and suicidal ideation in early adoles- cence: an Irish population-based study. J Adolesc. 2014;37(1):1–9.

93. NICE Guidelines. Eating Disorder: Recognition and Treatment, Version 1. Commissioned by the National Institute for Health and Care Excel- lence. London, UK; 2016.

94. Mussell MP, Mitchell JE, Weller CL, Raymond NC, Crow SJ, Crosby RD. Onset of binge eating, dieting, obesity, and mood disorders among subjects seeking treatment for binge eating disorder. Int J Eat Disord. 1995;17(4):395–401.

95. Crow SJ, Peterson CB, Swanson SA, et al. Increased mortality in bulimia nervosa and other eating disorders. Am J Psychiatry. 2009;166(12):1342–1346.

96. Campbell LC, Mill J, Uher R, Schmidt U. Eating disorders, gene- environment interactions and epigenetics. Neurosci Biobehav Rev. 2011;35(3):784–793.

97. Stice E, Gau JM, Rohde P, Shaw H. Risk factors that predict future onset of each DSM–5 eating disorder: predictive specificity in high- risk adolescent females. J Abnorm Psychol. 2017;126(1):38–51.

98. Lavender JM, Utzinger LM, Cao L, et al. Reciprocal associations between negative affect, binge eating, and purging in the natural environment in women with bulimia nervosa. J Abnorm Psychol. 2016;125(3):381–386.

99. Tambelli R, Cerniglia L, Cimino S, et al. An exploratory study on the influence of psychopathological risk and impulsivity on BMI and perceived quality of life in obese patients. Nutrients. 2017;9(5):E431.

100. Ballarotto G, Porreca A, Erriu M, et al. Does alexithymia have a mediating effect between impulsivity and emotional-behavioural functioning in adolescents with binge eating disorder? Clin Neuropsychiatry.2017;14(4):247–256.

101. Tafà M, Cimino S, Ballarotto G, Bracaglia F, Bottone C, Cerniglia L. Female adolescents with eating disorders, parental psychopathological risk and family functioning. J Child Fam Stud. 2017;26(1):28–39.

102. Cerniglia C, Cimino S, Ballarotto G, Tambelli R. Do parental traumatic experiences have a role in the psychological functioning of early adoles- cents with binge eating disorder? Eat Weight Disord. 2016;21(4):635–644.

103. Hudson JI, Lalonde JK, Berry JM, et al. Binge-eating disorder as a distinct familial phenotype in obese individuals. Arch Gen Psychiatry. 2006;63(3):313–319.

104. Salvy SJ, De La Haye K, Bowker JC, Hermans RC. Influence of peers and friends on children’s and adolescents’ eating and activity behaviors. Physiol Behav. 2012;106(3):369–378.

105. Stice E, Presnell K, Spangler D. Risk factors for binge eating onset in adolescent girls: a 2-year prospective investigation. Health Psychol. 2002;21(2):131–138.

106. Tin SP, Ho SY, Mak KH, Wan KL, Lam TH. Lifestyle and socioeco- nomic correlates of breakfast skipping in Hong Kong. Prev Med. 2011;52(3–4):250–253.

A

d o

le sc

e n

t H

e a

lth ,

M e

d ic

in e

a n

d T

h e

ra p

e u

tic s

d o

w n

lo a

d e

d f

ro m

h tt

p s:

// w

w w

.d o

ve p

re ss

.c o

m /

b y

1 7

4 .2

2 7

.3 .7

4 o

n 2

6 -O

ct -2

0 1

8 F

o r

p e

rs o

n a

l u se

o n

ly .

Powered by TCPDF (www.tcpdf.org)

1 / 1

  • _GoBack
  1. Publication Info 4: