Diabetes

Running head: Library activity 1

Locating Sources: Google Schorlar

Student Name {Rofiyat Adeoti}

Azure College: Course {English Composition}

Date {10/23/2020}

Locating Sources: Library activity 2

Locating Sources

One of the most important aspects of your research is your ability to locate sources related to your topic. Search the LIRN library and locate (3) publications related to your research topic. This will be a continual template where you add to it each course you take. Azure library is a resource for Discussion Questions and support empirical sources. Remember you will use these sources to strengthen your research, writing, and analyzing empirical sources. Type directly on this form, save it and submit it on canvas by assignment deadline for each course.

Number Article Information: Be sure entries are presented in alphabetical order.

EXAMPLE What is the title of the article: Education and Technology

What year was it published: 2014

List the author(s) by last name, first name: Bean, John and Smith, Susan

What is the journal title: Higher Education Today

What key words did you use to find the article: education, technology, classes,

distance education

What database did you use to find the article: Education

Summarize the publication 100 + word count:

The article discussed the importance of integrating technology into the classroom

setting………

1. What is the title of the article: Complications of Diabetes

What year was it published: 2016

List the author(s) by last name, first name: Papatheodorou, Konstantinos and

Papanas, Nikolaos and Banach, Maciej and Papazoglou, Dimtrios and Edmonds,

Michael

What is the journal title: Journal of Diabetes Research

Locating Sources: Library activity 3

What key words did you use to find the article: Diabetes, Complications, Causes,

and prevention

What database did you use to find the article: Health and Medicine

Summarize the publication: The article discussed about The Complications of Diabetes and how the Rate has increased over the Year. The prevalence of diabetes (DM) is constantly increasing worldwide at an alarming

rate. According to the International Diabetes Federation in 2015, an estimated 415

million people globally were suffering from this condition [1]. Complications of

DM account for increased morbidity, disability, and mortality and represent a threat

for the economies of all countries, especially the developing ones [2]. The present

special issue has been devoted to the recent progress in our understanding of

diabetic complications, including the underlying molecular mechanisms, new

diagnostic tools that facilitate early diagnosis, and novel treatment options. It

consists of 20 articles covering 5 thematic areas: (a) epidemiology and

pathogenesis of diabetic complications, (b) microvascular complications, (c)

macrovascular complications, (d) miscellaneous complications, and (e) treatment

options. (a) Epidemiology and Pathogenesis of Diabetic Complications. There is

growing evidence that the underlying mechanisms in the pathogenesis of diabetic

complications include certain genetic and epigenetic modifications, nutritional

factors, and sedentary lifestyle [3]. In a paper of this special issue entitled

“Epigenetic Studies Point to DNA Replication/Repair Genes as a Basis for the

Heritable Nature of Long Term Complications in Diabetes,” A. A. Leontovich et

al., using a zebrafish diabetic model, have explored the role of epigenetic

mechanisms on the persistence of diabetic complications even after euglycemic

Locating Sources: Library activity 4

control is achieved, a condition known as metabolic memory. They found that

DNA-methylation, in or near genes belonging to the DNA replication/DNA

metabolism process group, might play a key role in this process.

2. What is the title of the article: Cardiovascular Autonomic Neuropathies as

Complications of Diabetes Mellitus

What year was it published: 2012

List the author(s): Kuehl,Michael and Stevens, Martins J.

What is the journal title: Nature Reviews Endocrinology

What key words did you use to find the article: Cardiovascular, Diabetes Mellitus,

Complications, and Neuropathy

What data base did you use to find the article: Health and Medicine

Summarize the publication: The Article Discussed about how Cardiovascular autonomic neuropathy is a subgroup of diabetic autonomic neuropathy that is a common complication of long-term diabetes mellitus and contributes to poor quality of life and increased morbidity and mortality. This Review discusses methods for diagnosis, epidemiology, natural history and potential causes and consequences of cardiovascular autonomic neuropathy. Although, The natural history of CAN is unclear, but is thought to progress from a subclinical stage characterized by impaired baroreflex sensitivity and abnormalities of spectral analysis of heart rate variability to a clinically apparent stage with diverse and disabling symptoms. Early diagnosis of CAN, using spectral analysis of heart rate variability or scintigraphic imaging techniques, might enable identification of patients at highest risk for the development of clinical CAN and, thereby, enable the targeting of intensive therapeutic approaches. This Review discusses methods for diagnosis, epidemiology, natural history and potential causes and consequences of CAN.

3. What is the title of the article: Chronic Complications of Diabetes Mellitus:

What year was it published: 2017

List the author(s): Lotfy, Mohamed; Adeghate, Jennifer; Kalasz, Huba; Singh, Jaipaul;

Adeghate, Ernest

Locating Sources: Library activity 5

What is the journal title: Chronic Complications

What key words did you use to find the article: Diabetes mellitus; advanced

glycation-end products; angiopathy; hyperglycaemia; long-term

complications; neuropathy; oxidative stress

What database did you use to find the article: Health and Medicine

Summarize the publication: Diabetes mellitus (DM) is a major metabolic

disorder currently affecting over 350 million people worldwide. Also, another

one billion people in the world are pre-diabetic, who may eventually end up

with full- blown diabetes. It costs around 1,200 billion USD to diagnose, treat

and care for both type 1 DM (T1DM) and type 2 DM (T2DM) patients

globally. The disorder is rapidly increasing out of proportion in both

developed and developing countries, especially T2DM, which is associated

with modern lifestyle habits such as reduced physical activity, diet, obesity

and genetic factors. If left untreated, DM can lead to a number of diseases and

long-term complications leading subsequently to death.

In this mini review, they aim to highlight a number of complications, cascades

or pathways (polyol, hexosamine, protein kinase C, advanced glycation-end

product) of events and cellular, sub-cellular and molecular mechanisms

associated with DM-induced hyperglycaemia (HG).

Conclusion: Chronic complications of DM are caused largely by HG-induced

cellular and molecular impairment of neural and vascular structure and

function. HG-induced oxidative stress is a major contributor in the

Locating Sources: Library activity 6

development of long-term complications of DM. DM-induced neuropathy and

angiopathy, in turn, may lead to the dysfunction of cells, tissues and organ

systems.

Locating Sources: Library activity 7

References:

A. Naslafkih and F. Sestier, “Diabetes mellitus related morbidity, risk of hospitalization and

disability,” Journal of Insurance Medicine, vol. 35, no. 2, pp. 102–113, 2003.

Centers for Disease Control. National Diabetes Statistics Report, 2014. Centers for Disease

Control; 2015. Accessed October 5, 2015.

Centers for Disease Control and Prevention. Blindness caused by diabetes–Massachusetts,

1987. 1996; 45(43):937–941.

International Diabetes Federation, IDF Diabetes Atlas, International Diabetes Federation,

Brussels, Belgium, 7th edition, 2015, http://www.diabetesatlas.org.

Kuehl, M., Stevens, M. Cardiovascular autonomic neuropathies as complications of diabetes

mellitus. Nat Rev Endocrinol 8, 405–416 (2012). https://doi.org/10.1038/nrendo.2012.21

Tesfaye, S. et al. Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of

severity, and treatments. Diabetes Care 33, 2285–2293 (2010).