paper

Lecture18ImmuneSystem.ppt

War of the Worlds

1st line of defense

If that is breached…

Non-specific Response –
inflammation

Non-specific Response –
inflammation,
margination
&
diapedesis

Non-specific Response –
inflammation & ultrafiltration

Leukocytes & the innate
non-specific response

Leukocyte production
reminder

Non-specific Viral & Cancer
Response – interferon

Non-specific Viral & Cancer
Response –
Natural Killer Cells
(NK cells)
Assassins
with GENERAL instructions

Non-specific Response –
complement system
“exploding microbes”

Adaptive & Specific
“Acquired immunity”

SCIDS

Type: Gene Lymphocyte Phenotype

X-linked IL2RG T(-) B (+) NK (-)

Autosomal

ADA gene ADA T (-) B (-) NK (-)

Jak3 gene JAK3 T(-) B (+) NK (-)

IL-7R alpha IL7R alpha T (-) B (+) NK (+)

CD3 d or e CD3 d or e T (-) B (+) NK (+)

RAG1/RAG2 RAG1/RAG2 T (-) B (-) NK (+)

Artemis gene Artemis T (-) B (-) NK (+)

CD45 gene CD45 T (-) B (+) NK (+)

Cytotoxic T cells recognize
self-viral antigen complex

Upon costimulation with CD28 & MHC/antigen complex,
Cytotoxic T cells then give the
kiss of death – perforin

1st line of defense

Keratinocyte stimulates T cell maturation in the skin…and Langerhans provide the costimulator

Other T cells (beyond cytotoxic T cells)
* Helper T cells

A team effort
T cells and innate response in concert:

And that’s not all…

B cells – produce antibodies

B cells

B cells – plasma vs memory

B cells – antibody mediated specific
response

SCIDS treatment options

Science & Religion