Biomedical Sciences exam

Clinical Immunology and Immunohaematology 6BIOM003W

Case History Exam Section A July 2021

Patient HB is a non-sensitised, 45 year old male, who was diagnosed with kidney failure caused by IgA nephropathy. 30 months ago, he received a renal transplant from his wife, DB.

Initially the kidney functioned well, however over the last 6 months function has been deteriorating and there are signs of rejection.

Blood group HLA-A HLA-B HLA-Cw HLA- DR HLA-DQ

Patient HB (recipient)

O RhD +ve A*29, A*02 B*44, B*7

Cw*16, Cw*07

DRB1*11 DRB1*15

DQB1*0301 DQB1*06

Wife DB (Donor)

O RhD +ve A*03, A*02 B*27, B*44

Cw*02, Cw*05

DRB1*11 DRB1*04

DQB1*0301 DQB1*0302