short paper

500 words clear

Criteria

100 word Title and overview of factors:

Appropriate title to engage and interest retirees. Clear introduction with brief description of general background factors and interventions related to healthy brain ageing (covering at least 1-4).

-Summarize the general factors and interventions associated with healthy brain ageing

https://www.ncbi.nlm.nih.gov/books/NBK316205/

Factors

1- lifestyle factors and the physical environment

2- medical and physical factors

3- general approaches to remediation

250 word Description of selected factor and evidence:

One modifiable ageing factor is chosen for in-depth discussion including: action on cellular processes of brain ageing; summary of pre-clinical and clinical evidence of interventions related to that factor.

-Pick one of the factors/interventions you have mentioned and explain how your chosen focus factor may act on some of the cellular processes of brain ageing to lead to its effects. When choosing a factor, please choose a modifiable factor.

Factor: lifestyle factors and the physical environment

Modifiable factor: Exercise

-For the same factor/intervention elaborated on above, summarise the pre-clinical animal evidence and clinical trial evidence that interventions relating to that factor can improve age-related brain health decline (Meta-analysis or systematic review) paper.

200word. Intervention/treatment recommendations:

Provides detailed, specific, practical and targeted interventions with discussion of evidence base. Discusses risks and negative side effects, debates and caveats.

-Provide specific recommendations for concrete, practical activities that retirees can do to implement that factor/intervention (ie not just recommending they engage in the intervention, but if the intervention can take multiple forms, what are they and which has the most evidence? What exposure level/dose? How frequently? What potential negative effects/risks do they need to keep in mind?)  Ensure those recommendations are based on outcomes from studies, and explain any debate or caveats identified in the literature about which implementation is most effective.