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Health economic evaluations comparing faecal microbiota transplantation with antibiotics for treatment of recurrent Clostridioides difficile infection: a systematic review Lianna Hede Hammeken1* , Simon Mark Dahl Baunwall2, Christian Lodberg Hvas2 and Lars Holger Ehlers1

Abstract

Background: Faecal microbiota transplantation (FMT) is increasingly being used in the treatment of recurrent Clostridioides difficile infection (rCDI). Health economic evaluations may support decision-making regarding the implementation of FMT in clinical practice. Previous reviews have highlighted several methodological concerns in published health economic evaluations examining FMT. However, the impact of these concerns on the conclusions of the studies remains unclear.

Aims: To present an overview and assess the methodological quality of health economic evaluations that compare FMT with antibiotics for treatment of rCDI. Furthermore, we aimed to evaluate the degree to which any methodological concerns would affect conclusions about the cost-effectiveness of FMT.

Methods: We conducted a systematic literature review based on a search in seven medical databases up to 16 July 2020. We included research articles reporting on full health economic evaluations comparing FMT with antibiotic treatment for rCDI. General study characteristics and input estimates for costs, effectiveness and utilities were extracted from the articles. The quality of the studies was assessed by two authors using the Drummonds ten-point checklist.

Results: We identified seven cost-utility analyses. All studies applied decision-analytic modelling and compared various FMT delivery methods with vancomycin, fidaxomicin, metronidazole or a combination of vancomycin and bezlotoxumab. The time horizons used in the analyses varied from 78 days to lifelong, and the perspectives differed between a societal, a healthcare system or a third-party payer perspective. The applied willingness-to-pay threshold ranged from 20,000 to 68,000 Great Britain pound sterling (GBP) per quality-adjusted life-year (QALY). FMT was considered the most cost-effective alternative in all studies. In five of the health economic evaluations, FMT was both more effective and cost saving than antibiotic treatment alternatives. The quality of the articles varied, and we identified several methodological concerns. (Continued on next page)

© The Author(s). 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

* Correspondence: [email protected] 1Danish Center for Healthcare Improvements, Department of Clinical Medicine, Aalborg University, Fredrik Bajers Vej 5, DK-9220 Aalborg Ø, Denmark Full list of author information is available at the end of the article

Hammeken et al. Health Economics Review (2021) 11:3 https://doi.org/10.1186/s13561-021-00301-7

(Continued from previous page)

Conclusions: Economic evaluations consistently reported that FMT is a cost-effective and potentially cost-saving treatment for rCDI. Based on a comparison with recent evidence within the area, the multiple methodological concerns seem not to change this conclusion. Therefore, implementing FMT for rCDI in clinical practice should be strongly considered.

Keywords: Systematic review, Economic evaluation, Fecal microbiota transplantation, Faecal microbiota transplantation, Anti-bacterial agents, Decision making, Clinical decision-making

Background Clostridioides difficile infection (CDI) is an enteric infec- tion causing symptoms ranging from diarrhoea and ab- dominal discomfort to toxic megacolon and death [1, 2]. In Europe, the incidence rate for healthcare-associated CDI has been estimated to 23 per 10,000 admissions [3]. The standard treatment for CDI is antibiotics, but 20– 30% fail to achieve a sustained response and suffer re- currence [4, 5]. Current clinical guidelines recommend oral vancomycin

or oral fidaxomicin for the first recurrence of CDI (rCDI) and pulse/taper oral vancomycin, fidaxomicin or faecal microbiota transplantation (FMT) for any subsequent re- current episodes [6, 7]. FMT is a novel procedure by which minimally processed faeces from a thoroughly screened healthy donor is transferred to a patient to cor- rect a disrupted intestinal microbiota [8]. During the past decade, FMT has gained widespread recognition as a highly effective treatment for rCDI; effect rates exceeding 90% for FMT have been reported in observational studies [9, 10], and randomised controlled trials (RCTs) have found FMT to be comparable [11] or superior to anti- biotic treatments for patients with rCDI [12–14]. Healthcare systems worldwide are currently facing in-

creasing budgetary pressures due to an ageing popula- tion and expensive medical treatments [15], and the need is rising to include both clinical and economic con- siderations in the decision-making when implementing new technologies [16]. Health economic evaluations may help qualify these decisions by providing an analysis of the costs and consequences of two or more alternative technologies [16]. Given the growing interest in the use of FMT for rCDI treatment [17], it becomes important to support healthcare decision-making regarding the im- plementation of FMT in clinical practice. Previous sys- tematic reviews have evaluated the cost-effectiveness of providing FMT for both index CDI and rCDI and have highlighted several concerns about the methodological quality of existing health economic evaluations [18, 19]. However, the impact of these concerns on the conclu- sions of the studies has yet to be evaluated. The present study aimed to present an overview of

and to assess the quality of health economic evaluations that compare FMT with antibiotics in the treatment of

rCDI based on a systematic literature review. We further aimed to evaluate how any methodological concerns would affect the conclusions about cost-effectiveness based on a comparison with recent evidence within the area, and thereby hope to provide clear guidance for healthcare decision-makers.

Materials and methods This systematic review was conducted in accordance with the PRISMA guidelines for reporting of systematic reviews and meta-analyses [20].

Eligibility criteria Predefined criteria were applied to identify relevant stud- ies. We included full health economic evaluations com- paring FMT with any antibiotic treatment strategy for rCDI. A health economic evaluation was defined as a study comparing both the costs and consequences of al- ternative treatments, i.e. cost-benefit, cost-effectiveness or cost-utility analyses [16]. We excluded studies includ- ing only costs or consequences and article types other than research articles, e.g. reviews, editorials and confer- ence abstracts.

Search strategy A systematic literature search was conducted up to 16 July 2020 for all available literature in the following data- bases: PubMed, Embase, the Cochrane Library, Cinahl, Scopus, EconLit and the NHS Economic Evaluation Database. If the database allowed it, the search was lim- ited to English and Danish language. No other restric- tions were made. A combination of the following search terms was applied: ‘Clostridium difficile infection’ AND ‘fecal microbiota transplantation’ AND (‘economic evaluation’ OR ‘cost-benefit’ OR ‘cost-effectiveness’ OR ‘cost-utility’). The search terms were adjusted to the spe- cific databases and consisted of a combination of the- saurus terms and free-text search. The authors have previously reported a preliminary study using a similar search strategy in a conference abstract [21]. The complete search strategy used in the present systematic review is available in Additional file 1.

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Study selection After searching the specified databases, duplicates were removed using the reference managing software Ref- Works (ProQuest, Michigan, USA). Remaining dupli- cates were identified by comparing the title, author, year and journal of the studies and were manually removed. After the exclusion of duplicates, records were screened for inclusion based on the title and abstract. The full text of the remaining studies was then assessed. Two authors (LHH and SMDB) independently conducted the screen- ing and assessment for inclusion of records, and any dis- agreements were resolved by dialogue between the two authors.

Data extraction The following data on study characteristics were ex- tracted from the included records: author and year of publication, setting, analytic method, time horizon, per- spective, outcome measure, patient population, interven- tion, control treatment, willingness-to-pay threshold, results and the conclusion regarding cost-effectiveness. Also, input estimates applied for utilities, effectiveness and costs were extracted to a separate table. Costs were both presented as original values and converted to 2019- level Great Britain pound sterling (GBP). Extrapolation was done by applying a country-specific consumer price index [22]. Afterwards, purchasing power parity adjusted exchange rates were used to convert the estimates into GBP [23].

Quality assessment Methodological quality was assessed using the Drum- mond ten-point checklist for assessing economic evalua- tions [16]. The checklist consists of ten essential items and several subitems related to, e.g., the research aim and choice of comparators, the effectiveness measure, costs and outcome measures as well as the results and uncertainties of the analysis [16]. Two authors (LHH and LHE) assessed each of the studies and agreed on a final assessment. The results from the quality assessment were reported for each checklist item and categorised into the following four answers: yes (adequate), no (not adequate), cannot tell (unclear) or not applicable based on compliance with the checklist.

Results Study selection A total of 272 records were identified in the systematic literature search (Fig. 1). Fifty-one duplicates were re- moved, and the remaining 221 records were screened based on the eligibility criteria. Among these, 207 were excluded as they were not full health economic evalua- tions, did not compare FMT with antibiotic treatment or did not focus on rCDI. Thus, the full text of a total of 14

records was screened, and seven of these were included in the systematic review [24–30].

Study characteristics A schematic presentation of the general study character- istics is provided in Additional file 2. The studies origi- nated from the United States (n = 3) [24, 25, 29], Canada (n = 1) [26], Australia (n = 1) [27], France (n = 1) [28] and the United Kingdom (n = 1) [30] and were published between 2014 and 2020. All studies were cost-utility analyses based on decision-analytic modelling using ei- ther decision trees (n = 4) [24, 25, 28, 29] or Markov models (n = 3) [26, 27, 30]. The number of previous rCDI episodes differed between studies, ranging from the first to the third rCDI at inclusion. All studies included FMT administered by colonos-

copy, and some also included nasoduodenal/−gastric in- fusion (n = 5) [24, 26–28, 30], enema (n = 3) [24, 26, 28] or oral capsules (n = 1) [29]. The treatment of additional recurrences was either reported as repeat FMT or a shift to oral vancomycin. In all studies, the control treatment was oral vancomycin in different dosages and treatment regimens. Fidaxomicin was applied in most studies (n = 5) [24, 26, 28–30], whereas two studies included oral metronidazole [24, 26], and one study included the com- bination of oral vancomycin with bezlotoxumab [29]. In case of additional recurrences, the subsequent antibiotic treatment strategies differed in accordance with the number of previous rCDI episodes. The studies either applied a relatively short time hori-

zon of 78 days to 1 year (n = 5) [24, 25, 28–30] or a life- long time horizon (n = 1) [26], whereas the reported perspectives differed between a societal (n = 2) [24, 28], a third-party payer (n = 2) [25, 29] and a healthcare system perspective (n = 2) [26, 30]. The willingness-to-pay threshold ranged from 20,000 to 68,000 GBP per quality-adjusted life-year (QALY). FMT was estimated as the most cost-effective alterna-

tive in all studies. In five of the health economic evalua- tions, FMT strongly dominated, i.e. was both cost-saving and more effective than all the antibiotic treatment alter- natives [25–27, 29, 30]. However, the results differed with respect to FMT delivery method; FMT by colonos- copy was cost-effective in four of the studies [24–26, 29], whereas FMT by nasoduodenal/−gastric infusion was cost-effective in two studies [27, 30], and FMT by enema was the most cost-effective alternative in one study [28]. If the most cost-effective delivery method was unavailable, in five of the six studies including more than one delivery method of FMT, alternative delivery methods were also considered cost-effective compared with the antibiotic treatments [26–30]. Additional file 3 presents an overview of the cost-effectiveness of the dif- ferent delivery methods of FMT.

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Methodological quality assessment The methodological quality of each study was evaluated according to the Drummond ten-point checklist for assessing economic evaluations [16]. The overall evalu- ation is presented in Table 1. Detailed assessments of each article are available in Additional file 4, and a table

containing the inputs applied in the analyses is provided in Additional file 5.

Research aim and choice of alternatives Except for one study [27], a precise aim was reported in all studies including a description of the alternatives,

Fig. 1 Study selection flow-chart. The chart is adapted from the PRISMA-guidelines for reporting of systematic reviews [20]

Table 1 Results of the quality assessment of health economic evaluations

Item Konijeti et al., 2014 [24]

Varier et al., 2015 [25]

Lapointe-Shaw et al., 2016 [26]

Merlo et al., 2016 [27]

Baro et al., 2017 [28]

Luo et al., 2020 [29]

Abdali et al., 2020 [30]

Question 1. Research aim Yes Yes Yes No Yes Yes Yes

Question 2. Alternatives Yes Yes Yes Yes Yes Yes Yes

Question 3. Effectiveness Cannot tell Cannot tell Cannot tell Cannot tell Cannot tell Cannot tell Cannot tell

Question 4. Identification of costs and consequences

No No Yes Cannot tell No No No

Question 5. Measurement of costs and consequences

Cannot tell Cannot tell Yes Cannot tell Yes Cannot tell Yes

Question 6. Valuation of costs and consequences

Cannot tell Cannot tell Yes Cannot tell Yes Cannot tell Yes

Question 7. Extrapolation and discounting

NA NA Yes Yes NA NA NA

Question 8. Results Yes Yes Yes Yes Yes No Yes

Question 9. Sensitivity analyses Yes Yes Yes No Yes Yes Yes

Question 10. Discussion Cannot tell Cannot tell Yes No Cannot tell Cannot tell Yes

The items reported in the table are based on the main topic of each item in the checklist for assessing economic evaluations reported by Drummond et al., 2015 [16]. The answers reported in the table indicate the compliance with the checklist-item: yes (adequate method), no (not adequate method), cannot tell (unclear) or not applicable. The complete checklist can be accessed through the original source [16]. NA = not applicable

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patient population, time horizon and the perspective from which the analysis was conducted (Q1). The alternative treatments were sufficiently described to understand the field of research; and, according to international treatment guidelines [6, 7], the alternatives were meaningful treat- ments for patients with rCDI (Q2).

Effectiveness estimates The application of effectiveness estimates differed be- tween the studies. Whereas some separated the inputs for cure and recurrence of rCDI [24, 28–30], this was not explicitly done in others [25–27] (Additional file 4). Differences in the estimates were also observed between the studies; for example, the probabilities reported for cure ranged between 87.0 and 94.5% for FMT by colon- oscopy, 30.8 and 91.6% for oral vancomycin and 42.0 and 93.7% for fidaxomicin. Despite the differences in cure rates, FMT by colonoscopy was associated with the highest probability of cure in all studies. Considerable differences were, however, observed between the studies regarding the order of the probabilities of cure applied for other alternatives. Generally, the estimates of effectiveness were based on

evidence of varying quality including RCTs, cohort stud- ies and case series. Moreover, none of the studies ad- equately described how the parameter estimates for effectiveness were identified, selected and pooled for the analyses. Only one study included documentation of a pragmatic literature search as a basis for identifying model inputs; however, information on the choice of specific sources and pooling of estimates were not pro- vided [30] (Q3). Apart from one study, which included a head-to-head comparison trial of the two included alter- natives [27], all of the health economic evaluations seemed to have applied unadjusted indirect comparisons of the alternatives.

Cost and consequences Five studies applied a time horizon of ≤1 year in the ana- lyses [24, 25, 28–30], which limits assessment of all the relevant consequences of treatment alternatives when QALYs are used as the outcome measure. Moreover, all but one study applied utility estimates for rCDI from non-RCDI patient populations, e.g. patients with inflam- matory bowel disease or non-infectious diarrhoea, due to lack of evidence on utility estimates for patients with rCDI. The applied utility estimates for rCDI varied greatly from 0.42 to 0.88, whereas the differences be- tween rCDI patients and healthy people ranged from 0.06 to 0.36 (Additional file 4). One study reported a higher utility weight for patients with rCDI than for healthy people [27]. The most recent study applied a utility weight for rCDI based on patients with CDI and a utility weight for the healthy state based on general

population norms [30]. This produced a larger difference in utility estimates between rCDI patients and healthy people than in the other articles (Q5/Q6). The studies reported various perspectives for their

analyses. Two of the articles stated that a societal per- spective was applied [24, 28]. Nevertheless, in all studies, the costs seemed to be restricted to healthcare costs. Measurement and valuation of costs were generally not reported separately, and parameter estimates were drawn from a variety of sources including national fee sched- ules, previous research studies and micro-costing based on FMT protocols. Considerable differences were ob- served between the studies regarding the cost estimates applied for each treatment alternative; for example, the cost ranged between 840 GBP and 3158 GBP for FMT by colonoscopy, 203 GBP and 515 GBP for oral vanco- mycin, and 1368 GBP and 3155 GBP for fidaxomicin. For FMT, the cost-estimates were based on a variety of assumptions regarding the resource use associated with the treatment. Oral vancomycin or pulse-taper vanco- mycin was the least costly treatment alternative in most of the studies (n = 5) [24, 26–28, 30], whereas FMT by colonoscopy was the least costly in one study [25], and FMT by capsules was the least costly in another study [29]. The most expensive treatment was either fidaxomi- cin (n = 2) [24, 29], FMT by colonoscopy (n = 3) [27, 28, 30], FMT by enema (n = 1) [26] or pulse-taper vanco- mycin (n = 1) [25]. The inclusion of the risks and costs of adverse events and hospital admissions varied be- tween the studies (Q5/Q6) (Additional file 4). Costs were extrapolated to a specific reference year in each study, and discounting was used to adjust for differential timing if applicable, e.g. in studies with a time horizon exceeding 1 year [26, 27] (Q7).

Results and sensitivity analyses In most of the studies, the incremental cost-effectiveness ratio (ICER) was the primary outcome of the analysis. ICERs were calculated if none of the alternatives com- pared were considered dominant. In one study, however, an ICER was calculated between FMT by colonoscopy and FMT by oral capsules even though FMT by colonos- copy seemed to be dominant [29] (Q8). All studies ap- plied probabilistic sensitivity analyses, and all but one study included deterministic sensitivity analyses to char- acterise parameter uncertainties [27]. Examination of methodological and structural uncertainty or heterogen- eity was limited. In addition, the studies generally did not provide sufficient descriptions and justifications for the choice of estimates used in the sensitivity analyses. High probabilities that the FMT alternatives were cost- effective compared with antibiotics were found in the probabilistic sensitivity analyses [25–30], but the choice of delivery method was associated with some uncertainty

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[26–30] (Q9). Lastly, the studies varied with regards to their discussion of study limitations, generalisability and the need for future research (Q10).

Discussion In this study, we found that FMT was considered cost- effective in all of the included health economic evalua- tions. FMT was both cost-saving and more effective than antibiotics in five of the seven identified studies. Al- though the conclusions varied concerning the most cost- effective delivery method of FMT in all but one study, other delivery methods were still cost effective compared with antibiotic treatments if the preferred method of de- livery was unavailable. The study characteristics differed with regard to ana-

lytic method, time horizon, perspective, patient popula- tion, number of previous rCDIs, treatment alternatives and the willingness-to-pay threshold applied in the ana- lyses. We identified several methodological concerns that may potentially impact the conclusions of the stud- ies: the choice of effectiveness estimates, the time hori- zon used in the analysis and the selection of utility and cost estimates. The reporting of methods used to identify, select and

pool parameter estimates for effectiveness was sparse. Without this information, it becomes difficult to judge the validity and applicability of the data included in the analyses and to determine how any biases may impact the results [20]. In this systematic review, we found that the effectiveness measures were based on mixed quality evidence and unadjusted indirect comparisons, possibly resulting in biased estimates. Nonetheless, in all studies, at least one of the FMT delivery methods was associated with a higher probability of cure than all of the antibiotic treatment alternatives. This is in accordance with three out of four RCTs investigating the efficacy of FMT com- pared with vancomycin [12, 13] and fidaxomicin [14], in which a substantial benefit of FMT (> 39 percentage points) was identified, thereby supporting the validity of the findings of FMT being a cost-effective alternative. Five studies applied a relatively short time-horizon of

≤1 year in their analyses [24, 25, 28–30]. In general, the time horizon should be sufficiently long to capture all differences in cost and effects [16]. Studies have found that patients with CDI have a significantly higher mor- tality risk than patients without CDI [31, 32]. Because FMT is expected to have a higher probability of cure than alternative treatment modalities [12–14], patients who receive FMT will, on average, spend less time with CDI than patients treated with other alternatives and thus have a lower risk of dying from CDI. In order to obtain valid cost-effectiveness estimates, this mortality risk difference should be included in the analysis. When QALYs are used as the outcome measure, a short time

horizon will most likely not include all of the associated benefits of FMT; and in terms of cost-effectiveness, the results will therefore be biased in favour of antibiotic treatments. Consequently, all other things being equal, FMT may even be more cost-effective than presented in the studies that applied a short time horizon. The QALY estimate is also affected by the chosen

rCDI utility weights. In six studies, the utility weights were drawn from patients with other conditions than rCDI [24–29]. Recent studies have published utility esti- mates for patients hospitalised with an index or recur- rent CDI measured by the EuroQol 5-Dimensions 3- Level (EQ-5D-3L)-questionnaire [33, 34]. The only health economic evaluation applying a CDI-specific utility weight [30] based its input on a UK study by Wilcox et al. [33] in which the authors estimated a utility weight of 0.42 for pa- tients with CDI. A recent French study [34] estimated a utility weight of 0.05 which indicates that substantial vari- ations may exist among patients with CDI. All of these values are significantly lower than the values applied in the remaining health economic evaluations [24–29]. As discussed previously, patients treated with FMT are ex- pected to spend less time with CDI than patients treated with alternatives to FMT. A larger difference in utility weights between healthy patients and patients with CDI would, therefore, lead to FMT being even more cost- effective than concluded in most of the studies. However, a multinational study by Heinrich et al. [35] based on the 36-item Short Form Health Survey (SF-36) found a utility weight of 0.58 and 0.64 in patients with a current and pre- vious CDI episode, respectively. This difference between CDI and “healthy” patients is smaller than the differences applied in most of the health economic evaluations. Though even if this narrow difference was applied, FMT would produce a higher accumulation of QALYs than less effective alternatives and, all other things being equal, FMT would still be the dominant treatment option in the five identified studies in which FMT was associated with lower costs [25–27, 29, 30]. When considering the costs of FMT, the procedure

may be divided into three elements: donor recruitment and screening, laboratory processing, and clinical appli- cation and follow-up [36]. Currently, these elements vary from one setting to another [37]. This variability may affect both the resource use and effectiveness of FMT, and different processes may, therefore, produce different cost-effectiveness estimates. In some of the studies in- cluded in this systematic review, the FMT process was not described in detail, limiting the applicability of the study results in other specific clinical settings. In addition, large variations in the cost estimates for both FMT alternatives and antibiotic treatment alternatives were observed between the health economic evaluations. The cost estimate for a single treatment with the FMT

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alternatives was higher than for a single treatment with vancomycin in most of the studies. Even so, owing to the increased effectiveness of FMT, which yields a more limited risk of recurrence and its associated costs, all studies concluded that FMT is a cost-effective treatment for rCDI, and some studies reported that FMT may even be cost saving compared with antibiotic treatment alternatives. In the present study, we performed a systematic litera-

ture search in several databases and included methodo- logical quality assessment of the included studies. Quality assessments are subjective evaluations [38] and our results might therefore not be consistent with those of others. Yet, the quality assessments in this study were conducted by two authors who agreed on the final evalu- ation, and to enhance the transparency of our assess- ment, we present a detailed quality assessment of each of the studies in Additional file 4. Future research on the cost-effectiveness of FMT

should improve the quality of reporting to aid an assess- ment of the methodological quality as well as the applic- ability and generalisability of the analyses. The use of acknowledged methods for identification and synthesis of effectiveness estimates and the use of a life-long time- horizon to capture all relevant costs and consequences would increase confidence in the results of health eco- nomic evaluations based on decision analytic modelling. Moreover, there is a need for additional primary re- search on the health-related quality of life of patients with rCDI to inform future cost-utility analyses.

Conclusions FMT is reported as a highly cost-effective treatment al- ternative compared with antibiotic treatments for pa- tients with rCDI. The identified health economic evaluations varied with respect to many study character- istics and several methodological concerns applied. Con- sidering that recent RCTs have found FMT to be a substantially more effective treatment for rCDI than an- tibiotics, these concerns do, however, not seem to change the conclusion regarding cost-effectiveness. Still, due to the unstandardised nature of FMT, decision- makers should be aware that the magnitude of costs and effects of FMT may be context specific. Based on the currently available evidence, increased implementation of FMT for rCDI treatment in clinical practice should be strongly considered.

Supplementary Information The online version contains supplementary material available at https://doi. org/10.1186/s13561-021-00301-7.

Additional file 1. is a .pdf file which contains information on the complete search strategy used in the present systematic review.

Additional file 2. is a .pdf file which contains a table with the general study characteristics of the included health economic evaluations.

Additional file 3. is a .pdf file which presents an overview of the cost- effectiveness of the different delivery methods of FMT.

Additional file 4. is a .pdf file which contains detailed quality assessments of each of the included health economic evaluations.

Additional file 5. is a .pdf file which contains a table with the inputs applied in the health economic evaluations.

Abbreviations CDI: Clostridioides difficile infection; rCDI: recurrent Clostridioides difficile infection; FMT: Faecal microbiota transplantation; RCT: Randomised controlled trial; GBP: Great Britain pound sterling; QALY: Quality-adjusted life- years; ICER: Incremental cost-effectiveness ratio; EQ-5D-3L: EuroQol 5- Dimensions 3-Level; SF-36: 36-Item Short Form Health Survey

Acknowledgements Not applicable.

Authors’ contributions LHH had the primary role in conducting the study. All authors contributed to the study design and data interpretation. LHH, SMDB and LHE took part in the data collection. LHH drafted the first version of the manuscript. SMDB, CLH and LHE critically revised the manuscript. All authors agreed to be accountable for the work and approved the final manuscript and the list of authorship.

Funding The Innovation Fund Denmark has financially supported the study (grant no. 8056-00006B). The Innovation Fund Denmark did not have any influence on the design and conduct of the research or composition of the manuscript.

Availability of data and materials Data supporting the conclusions of this article are included within the article and in additional files.

Ethics approval and consent to participate Not applicable.

Consent for publication Not applicable.

Competing interests The authors declare that they have no competing interests.

Author details 1Danish Center for Healthcare Improvements, Department of Clinical Medicine, Aalborg University, Fredrik Bajers Vej 5, DK-9220 Aalborg Ø, Denmark. 2Department of Hepatology and Gastroenterology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, DK-8200 Aarhus, Denmark.

Received: 21 October 2020 Accepted: 4 January 2021

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