Discussion Paper
Chapter 9
Alcohol
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Fermentation
Production of alcohol from sugars through the action of yeasts
Forms the basis of all alcoholic beverages
Raw materials
Fruit contains sugar and will ferment with the addition of yeast
Cereal grains require malt to convert starch into sugar
Yeast has a limited tolerance for alcohol
When the concentration reaches 12-15% the yeast dies and fermentation ceases
Fermentation Products
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Distillation
Evaporation and condensing of alcohol vapors to produce beverages with higher alcohol content
Process perhaps discovered in Arabia around AD 800
Introduced into Europe in about the 10th century
Proof
A measure of a beverage’s alcohol content
Twice the percentage of alcohol by weight
90-proof whiskey is 45 percent alcohol
Distilled Products
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Production process:
Made by adding barley malt to other cereal grains
Hops are added with yeast to give beer its distinctive flavor
Most beer sold in the United States is mass-produced by the two largest brewers
Imported beers and microbreweries are growing in popularity
Beer
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Ale
Uses a top-fermentation yeast
Warm temperature and shorter fermentation
Lager (Most common type in U.S.)
Uses a type of yeast that settles to the bottom of the mash to ferment
Cool temperature and slower fermentation
Light beer
Fermented longer at a cooler temperature
More sugar is converted to alcohol
Then water is added
Types of Beer
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Production:
Made from fermented grapes
Produced by both small and large wineries
Most wines contain about 12% alcohol
Factors in quality include
Selection and cultivation of grapevines
Good weather
Timing of harvest
Careful monitoring of fermentation and aging
Wine
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Generics vs. varietals
Determined by type of grapes and flavor
Red vs. white
Sweet vs. dry
Sparkling wines
Fortified wines
Alcohol content near 20 percent
Varieties of Wine
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Image source: © Andersen Ross/Getty Images (Image Ch09_08WineShopping)
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Grain neutral spirits
Clear, tasteless, nearly pure alcohol (190 proof) produced by distillation
Sold as Everclear to consumers and used in research
Used to make various beverages
Gin: distillate filtered through juniper berries and then diluted with water
Vodka: mixture of grain neutral spirits and water
Contains relatively few congeners
Other alcohols and oils contained in alcoholic beverages
Distilled Spirits
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Whiskey
Distillate of fermented grain
Distilled at a lower proof (160) and so contains more congeners and some flavor from the grain
Usually aged for at least two years
Types of whiskey include:
Rye whiskey
Corn whiskey (bourbon)
Blended whiskey
Distilled Spirits
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Image source: Library of Congress Prints and Photographs Division [LC-USZC4-6495]
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Before American Revolution
Most people drank more alcohol compared with water
Drunkenness was viewed as misuse of positive product
After American Revolution
Alcohol itself viewed as the cause of serious problems
Alcohol was first psychoactive substance to become demonized in American culture
Early U.S. Views on Alcohol Use
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Benjamin Rush
Wrote pamphlet
“An Inquiry into the Effects of Ardent Spirits on the Mind and Body”
Heavy drinking = health problems
Alcohol use damages morality
Alcohol addiction = a disease
Temperance societies
Initially promoted abstinence from distilled spirits only
Later promoted total abstinence
Became fashionable to “take the pledge”
Temperance Movement
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States began passing prohibition laws in 1851
By 1917, 64% of Americans lived in “dry” territory
Laws reflected issues of class, ethnicity, religion, immigration
Federal prohibition
18th Amendment (1919): banned the sale of alcohol
People still drank illegally in speakeasies and private clubs and legally through purchase of patent medicines
Enforcement was challenging and expensive
Outcomes of Prohibition included:
Organized crime became more organized and profitable
Alcohol dependence and alcohol-related deaths declined
Prohibition
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Repealed by the 21st Amendment (1933)
Reasons for the repeal:
Alcohol taxes had been a major source of revenue
Concerns that widespread disrespect for Prohibition laws encouraged a general sense of lawlessness
Outcomes of repeal included:
Alcohol per capita sales and consumption increased
Returned to pre-prohibition levels after World War II
Prohibition
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Regulation after 1933
Some states remained dry initially
but most allowed beer sales
Mississippi was the last dry state
allowed alcohol purchase and consumption in 1966
In 1970s, drinking ages were lowered to 18–19 in 30 states
but raised again to 21 following safety concerns
Taxation
Federal and state taxes and licensing fees = about half the price of an alcoholic beverage
When taxes go up, consumption goes down
but not dramatically
Regulation and Taxation
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Consumption patterns are influenced by cultural factors
Trends in U.S. alcohol consumption
Similar to other drugs, alcohol use peaked in 1981 and then declined
American consumption per person per year:
Beer (27 gallons or over 1 gallon of alcohol)
Spirits (0.75 gallon of alcohol)
Wine (0.33 gallon of alcohol)
Alcohol Consumption Patterns
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U.S. Alcohol Consumption
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Figure 9.1 from text
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Regional differences in the U.S.
One third of U.S. population abstain
Half the alcohol is consumed by 10% of the drinkers
Differences in urbanization:
Alcohol sales higher in population centers (for example, D.C. and cities in Nevada)
U.S. Alcohol Consumption
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U.S. Alcohol Consumption by State
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Figure 9.2 from text
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Gender differences
Males more likely to drink than females
Males more likely to drink more
Drinking among college students
College students drink more than their nonstudent peers
Many campuses have banned sale and advertising of alcohol
Many fraternities have banned keg parties
There is some evidence that this is helping:
Fewer students binge drinking
Fewer students driving after drinking
U.S. Alcohol Consumption
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Standard drink has about 0.5 ounces of pure alcohol
12 ounces of beer
4 ounces of wine
1 ounce of 100-proof spirits
What is One Drink?
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Absorption
Most absorbtion in the small intestine
Some absorbed in the stomach
Slower if there is food or water in the stomach
Faster in the presence of carbonated beverages
Distribution
Blood alcohol concentration (BAC)
measure of the concentration of alcohol in blood, expressed as a percentage in terms of grams per 100 ml
Alcohol is distributed throughout body fluids but not fatty tissues
Thus, a lean person will have a lower BAC than a fatter person of the same weight
Pharmacology
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Pharmacology
Metabolism
Liver metabolizes about 0.25 ounces of alcohol per hour
If rate of intake = rate of metabolism, BAC is stable
If rate of intake exceeds rate of metabolism, BAC increases
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Figure 9.3 from text
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About 90 percent is metabolized in the liver
About 2 percent of alcohol is excreted unchanged
Breath
Skin
Urine
Alcohol
Acetaldehyde
Acetic acid
Alcohol
dehydrogenase
Aldehyde
dehydrogenase
Alcohol Metabolism
+
+
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Metabolism is based on a stable rate
Exercise, coffee, and other strategies do not speed up the rate of metabolism
Liver responds to chronic intake of alcohol by increasing enzyme activity
Contributes to tolerance among heavy users
For heavy alcohol users
When alcohol is present, metabolism of other drugs is slower
When alcohol is not present, metabolism of other drugs if faster
Alcohol Metabolism
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Women may be more susceptible than men to the effects of alcohol after consuming the same amount
Explanations:
Absorption: women tend to weigh less and have a higher proportion of body fat
Thus, women absorb a greater proportion of the alcohol they drink
Metabolism: alcohol dehydrogenase is less active in women
Sex Differences
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In general, alcohol is a central nervous system depressant
Exact mechanism of action is not clear
Alcohol has many effects on the CNS
Alcohol enhances the inhibitory effect of GABA at the GABA-A receptor
Similar to barbiturates and benzodiazepines
At high doses, alcohol blocks glutamate
Alcohol also affects dopamine, serotonin, and acetylcholine neurons
Mechanism of Action
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Mood changes can include:
euphoria
reduced anxieties
reduced inhibitions
Effects are dose-dependent
Blood alcohol concentration determines effects
For example:
At low blood levels, complex and abstract behaviors may be disrupted
At higher blood levels, simpler behaviors may be affected
Behavioral Effects
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Effects depend on the time course
For example, effects are greater when BAC rises rapidly
Effects are influenced by the individual’s alcohol experience
For example, a higher BAC is needed to impair a chronic heavy drinker
Effects are influenced by expectations
For example, placebo effects explain many of the effects on social behavior
Behavioral Effects
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Image source: © The McGraw-Hill Companies, Inc./Gary He, photographer (Ch09_21CollegeDrinking);
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BAC and Behavioral Effects
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| BAC (%) | Behavioral Effects |
| 0.05 | Lowered alertness, release of inhibitions, impaired judgment |
| 0.10 | Slower reaction times, impaired motor function, less caution |
| 0.15 | Large, consistent increases in reaction time |
| 0.20 | Marked depression in sensory and motor capability, intoxication |
| 0.25 | Severe motor disturbance, staggering, great impairment |
| 0.30 | Stuporous but conscious—no comprehension of what’s going on |
| 0.35 | Surgical anesthesia; about LD1, minimal level causing death |
| 0.40 | About LD50 |
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Approximately 40 percent of all traffic crash fatalities are linked to alcohol use
2011 data indicate that total fatalities have dropped to about 32,000
Driving Under the Influence
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SOURCE: H. Y. Yi and others, “NIAAA Surveillance Report #76: Trends in Alcohol-Related Traffic Fatalities in the United States, 1982–2004 (Bethesda, MD: USPHS, 2006)
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Risk of a fatal crash is dose-related
Sharp increase in fatalities with BAC over 0.10
Men are more likely than women to be involved in an alcohol-related fatal crash
The majority of alcohol-related individuals are not “problem drinkers”
Driving Under the Influence
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Sexual behavior
Alcohol use may enhance interest in sex but impair physiological arousal
Linked to risky sexual behavior
Blackouts
A danger sign of excessive alcohol use
Crime and violence
Alcohol use is statistically related to:
Homicide
Assault, including family violence, sexual assault, and date rape
Suicide
Behavioral Effects
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Peripheral circulation
Dilation of peripheral blood vessels
drinkers lose body heat but feel warm
Fluid balance
Alcohol has a diuretic effect that:
Increases urine flow
Lowers blood pressure in some individuals
Hormonal effects
Chronic alcohol abusers can develop a variety of hormone-related disorders
For example, disrupted reproductive functioning
Physiological Effects
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Two pieces of advice:
If someone drinks enough to pass out
Do not leave the person alone
Place her or him on side and monitor breathing or take to ER immediately
If someone drinks enough to vomit
S/he should stop drinking
Vomiting reflex is suppressed at BACs above 0.20 and can quickly reach lethal levels
Acute Physiological Toxicity
Alcohol overdose is relatively common and dangerous
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Image source: © Brand X Pictures (Image Ch09_26AlcoholToxicity)
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Hangovers are not well understood
Symptoms:
upset stomach, fatigue, headache, thirst, depression, anxiety, and general malaise
Possible causes:
alcohol withdrawal, exposure to congeners, cellular dehydration, gastric irritation, reduced blood sugar, and/or the accumulation of acetaldehyde
What is a Hangover?
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Brain tissue loss and cognitive impairment
Wernicke-Korsakoff syndrome
Heart disease:
Cardiomyopathy, heart attack, hypertension, stroke
Although moderate alcohol use may reduce heart attack risk
Liver disease
Hepatitis, fatty liver, cirrhosis
Chronic Toxicity in Heavy Users
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Image source: © Martin M. Rotker/Science Source
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Fetal Alcohol Syndrome (FAS)
Facial and developmental abnormalities associated with mother’s alcohol use during pregnancy
Related to peak BAC and to duration of alcohol exposure
Prevalence: 0.2–1.5 per 1,000 births
Diagnostic criteria (one must be present)
Growth retardation before and/or after birth
Pattern of abnormal features of the face and head
Evidence of CNS abnormality
Fetal Alcohol Syndrome
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Image Source: Amanda Mills/CDC
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Fetal alcohol effects
All alcohol-related developmental abnormalities associated with prenatal alcohol exposure
Prevalence: 80 to a few hundred per 1,000 births
Drinking during pregnancy increases risk of spontaneous abortion
Data do not prove that low levels of alcohol use during pregnancy are safe or that they are unsafe
Alcohol and Pregnancy
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Abstinence syndrome is medically more severe and more deadly than opioid withdrawal
If untreated, mortality can be as high as 1 in 7
Stages of withdrawal:
Stage 1: tremors, rapid heartbeat, hypertension, heavy sweating, loss of appetite, insomnia
Stage 2: hallucinations (auditory, visual, and/or tactile)
Stage 3: delusions, disorientation, delirium
Stage 4: seizures
Detoxification should be carried out in an inpatient medical setting
Sedatives given in stage 1 or 2 prevent stages 3 and 4
Withdrawal Syndrome
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Alcoholics Anonymous view
Alcohol dependence as a progressive disease characterized by loss of control over drinking
Only treatment is abstinence from alcohol
Disease model: alcohol dependence is the primary disease and not the result of another underlying cause
Alternative view: APA explicitly defines alcohol use disorder
Alcohol use disorder is a complex psychosocial disorder
Cognitive and genetic factors are of current scientific interest
Dependent Behaviors
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