Stem Cell Research

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Findings in the Area of Mesenchymal Stem Cells Reported from Beijing Hospital (Human Umbilical Cord Mesenchymal Stem Cell-derived Conditioned Medium Promotes Human Endometrial Cell Proliferation Through Wnt/beta-catenin Signaling). Date: Nov. 17, 2022 From: Women's Health Weekly Publisher: NewsRX LLC Document Type: Report Length: 542 words

Full Text:  2022 NOV 17 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- Investigators publish new report on Stem Cell Research - Mesenchymal Stem Cells. According to news reporting from Beijing, People's Republic of China, by NewsRx journalists, research stated, "Mesenchymal stem cells (MSCs) and their derivant are among the promising treatments for intrauterine adhesion (IUA); they have been reported to repair the endometrial injury by proliferating endometrial cells. However, the signal pathways involved are not clear."

Financial support for this research came from Beijing Dongcheng Department of Science, Technology.

The news correspondents obtained a quote from the research from Beijing Hospital, "This study investigated the role of human umbilical cord mesenchymal stem cell-derived conditioned medium (hUCMSC-CM) in relieving IUA to find out whether Wnt/beta- catenin signaling was involved, and if so, to determine the possible ligands. After endometrial epithelial cells (EECs) were treated with hUCMSC-CM, their proliferation and migration were measured by the CCK8 assay and the scratch assay. The activation of Wnt/beta- catenin signaling was measured by Western blots, fluorescent staining, and T-cell factor/lymphoid enhancer factor (TCF/LEF) luciferase. A Wnt inhibitor (XAV393) was used to inhibit the proliferation effect of hUCMSC-CM in EECs. Wnt5a expression in hUCMSC was measured by Western blots and fluorescent staining, and Wnt5a in hUCMSC-CM was detected by enzyme-linked immunosorbent assay (ELISA), to further clarify the mechanism. As shown by the CCK8 assay, hUCMSC-CM promoted proliferation and migration of EECs. The expression of beta-catenin, c-myc, and cyclin D1 increased in EECs after being treated with hUCMSC- CM. Moreover, hUCMSC-CM was found to promote beta-catenin delivery into nuclei by Western blot and fluorescent staining; meanwhile, the inhibitor (XAV393) could restrain this process and inhibit the effect of hUCMSC-CM on EEC proliferation. Wnt5a was detected in hUCMSCs and hUCMSC-CM, which might be a potential therapeutic target. This study demonstrated that hUCMSC-CM promoted human endometrial cell proliferation through Wnt/beta-catenin signaling, and Wnt5a might be a potential activator."

According to the news reporters, the research concluded: "This would be one of the activating signal pathways in the MSC-related treatment of IUA."

For more information on this research see: Human Umbilical Cord Mesenchymal Stem Cell-derived Conditioned Medium Promotes Human Endometrial Cell Proliferation Through Wnt/beta-catenin Signaling. BioMed Research International, 2022;2022. BioMed Research International can be contacted at: Hindawi Ltd, Adam House, 3RD Flr, 1 Fitzroy Sq, London, W1T 5HF, England.

Our news journalists report that additional information may be obtained by contacting Shaowei Wang, Chinese Academy of Medical Sciences, Beijing Hospital, Inst Geriatr Med, National Center of Gerontology, Beijing, People's Republic of China. Additional authors for this research include Xiaoning Wei, Sichen Zhang, Xinyu Xu, Feiran Liu, Jin Li, Qingyu Wang and Jianping Cai.

Keywords for this news article include: Beijing, People's Republic of China, Asia, Armadillo Domain Proteins, Catenins, Cell Proliferation, Gynecology, Health and Medicine, Mesenchymal Stem Cells, Proteins, Stem Cell Research, Transcription Factors, Women's Health, beta Catenin, Beijing Hospital.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2022, NewsRx LLC

The citation for this news report is: NewsRx. Findings in the Area of Mesenchymal Stem Cells Reported from Beijing Hospital (Human Umbilical Cord Mesenchymal Stem Cell-derived Conditioned Medium Promotes Human Endometrial Cell Proliferation Through Wnt/beta-catenin Signaling). Women's Health Weekly. November 17, 2022; p 2356.

Copyright: COPYRIGHT 2022 NewsRX LLC http://www.newsrx.com/newsletters/Womens-Health-Weekly.html Source Citation (MLA 9th Edition)    "Findings in the Area of Mesenchymal Stem Cells Reported from Beijing Hospital (Human Umbilical Cord Mesenchymal Stem Cell-

derived Conditioned Medium Promotes Human Endometrial Cell Proliferation Through Wnt/beta-catenin Signaling)." Women's Health Weekly, 17 Nov. 2022, p. 2356. Gale OneFile: Business, link.gale.com/apps/doc/A726409342/GPS?u=lirn50909&sid=bookmark-GPS&xid=6f31cad6. Accessed 7 Feb. 2023.

Gale Document Number: GALE|A726409342