Drug Analysis Narrated Powerpoint Presentation

Drug Analysis Narrated Powerpoint Presentation

You will prepare a narrated powerpoint presentation about a drug or medication of your choice and upload it to Blackboard. You must cite at least three sources. Pick a drug or medication of interest to you (if you need help finding a drug, a list of sources and possible options is included, but you are not limited to those suggestions) and obtain the structure of the drug (links to a few sites that provide drug structure and function information are also listed below). Once you have chosen a drug, please post your choice on the discussion board on the Blackboard site so I don’t see duplicates. In your presentation, you will discuss the structural and chemical properties of the drug, the disease/condition it is intended to treat, and how the drug functions. You are limited to 10-15 minutes, so you need to spend time figuring out what is most important and how to present that concisely. A general rule is to assume you will spend one minute per slide, so shoot for 10-15 slides and adjust from there. I will upload instructions on how to add narration to your powerpoint slides, if you don’t know.

Your presentation should minimally include information on the following:

1) Chemistry of the drug

· where and when the drug was first discovered and/or synthesized

· the structure of the drug and identification of the functional group(s) present

· a discussion of the functional groups present and how they affect the drug’s chemical properties (such as polarity, solubility, hydrogen bonding, etc.) and its function

· any other chemical information you find interesting.

2) Biochemistry of the drug

· basic biochemistry of the disease/condition the drug is intended to treat

· how the drug functions to treat the disease/condition

· details of the direct target (often a protein) of the drug (and/or the enzymes and/or pathways involved)

· any other biochemical information you find interesting

Drug structure and function links:

http://www.3dchem.com/

Chemistry and structure of medicines: a visual and interactive website showcasing the beautiful world of chemistry

https://go.drugbank.com/

Also provides structures and mechanism of action of drugs, among lots of other useful info

https://go.drugbank.com/biotech_drugs

(same as above, different entry point)

http://www.biopsychiatry.com/structures/index.html

Possible drug choices (you are not limited by the lists below):

General: cold/allergy/asthma, painkillers (over the counter or prescription), prevention of cardiovascular and coronary events (statins etc), ADHD, Diabetes (Avandia…), heartburn/reflux (Prevacid…), vitamins, stimulants, illicit drugs, supplements…

Antibiotics (introductory list below):

Kanamycin, Penicillins (penicillin, amoxicillin, methicillin), Cepahlosporins, methicillin, Tetracycline, Chloramphenicol, macrolide antibiotics , Beta-lactams, Azithromycin, Vancomycin

Anti-virals:

Influenza:

Neuramindase inhibitors, Tamiflu (Oseltamivir) , Zanamivir (Relenza), Laninamivir (Inavir), Peramivir

HIV/AIDS: http://www.aidsmeds.com/list.shtml

Too many to list; may include the following classes of drug:

Reverse Transcriptase Inhibitors, Protease Inhibitors, Entry Inhibitors, Integrase inhibitors, Multi-class combination drugs

Others: Interferons (hepatitis), Acyclovir (herpes),

Cancer drugs http://www.cancer.gov/cancertopics/druginfo/alphalist

(kinase inhibitors, Avastin, Tarceva(erlotinib), Gleevec, tamoxifen, Herceptin, many others. Most are cancer specific, so you can also search for drugs against a specific type of cancer.

High blood pressure medication: Angiotensin-converting enzyme (ACE) inhibitors, Angiotensin II receptor blockers, Beta blockers, Calcium channel blockers, Renin inhibitors (ex: Zestril, Cozaar, Levatol, diltiazem, Tekturna)