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Hospital Acquired Bloodstream Infection by Multi Drug Resistant Organisms-Alarming and Challenging Issue in the Intensive Care Units at Present Era.

Banerjee, Barnini Mondal, Soumayan Eshwara, Vandana Kalwaje Mukhopadhyay, Chiranjay [email protected] Varma, Muralidhar

Journal of Pure & Applied Microbiology. Dec2020, Vol. 14 Issue 4, p2595-2601. 7p.

Article

*INTENSIVE care units *ENTEROCOCCAL infections *NOSOCOMIAL infections *LUNG infections *MYCOPLASMA pneumoniae infections *TEACHING hospitals *KLEBSIELLA pneumoniae *ARTIFICIAL respiration

bacteremia Intensive care unit multidrug resistant pulmonary infection

Hospital-acquired bloodstream infections (BSIs) cause high mortality in the intensive care units (ICUs) compared to wards. Furthermore, the isolation of multidrug resistant (MDR) organisms in ICUs add to the gravity of the condition making the treatment a bigger challenge. The present study was aimed to evaluate the prevalence, spread, and the possible MDR organisms contributing to ICU-acquired BSI & the source of the secondary BSI in the ICUs. A prospective study was conducted in four ICU of tertiary teaching hospital over a period of six months. Patient that developed features of BSI within 48 hours after hospital admission were included in the present study Blood culture was performed by an automated BacT/ALERT®3D system. The source of secondary BSI was identified by analysing culture results for the samples other than blood. These samples were taken within 48 hours of the patient's blood culture test being positive. A total of 50 patients (25%) had an ICU acquired bloodstream infection. Out of 50 patients, 74% of them had bacterial etiology. Thirty one patients (62%) among them developed multidrug resistant bacteraemia. Fifty six percent of Gram negative bacilli were multi drug resistant. The resistance to carbapenem was 42%. The most common MDR Gram negative isolate was identified as Klebsiella pneumoniae (n=12; 38.7%,) and the most common source was pulmonary infection (26.7% (n=12). 42% of isolates in our study were carbapenem resistant suggesting the need for a proper antibiotic policy in the ICUs. Prolonged stay in the ICU with mechanical ventilation was the critical risk factor and ICU mortality was high (38%). [ABSTRACT FROM AUTHOR]

Copyright of Journal of Pure & Applied Microbiology is the property of Dr. M. N. Khan and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Department of Microbiology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka - 576 104, India Kasturba Medical College, Manipal, Manipal Academy of Higher

Education, Manipal, Karnataka - 576 104, India Department of Medicine, Kasturba Medical College, Manipal, Manipal

Academy of Higher Education, Manipal, Karnataka - 576 104, India

0973-7510

10.22207/JPAM.14.4.35

147972703

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