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Module 1 Assignment: Case Study Analysis

Nnenna Nwagbo

Walden University

NURS-6501 Week 2

12/14/2020

Review WU template for all components to be included on the title page.

Module 1 Assignment: Case Study Analysis

Introduction

In such a case study, there are various factors which should be considered other than the isolated cell behavior (consider clarifying what is meant by isolated cell behavior) . Such factors include the genes of the involved patient, the location (clarify location) and environmental condition of the given area (what is the intention by “given area”?) and the prevailing characteristics (what are prevailing characteristics of the patient?) of the given patient. In addition, race Race and ethnicity of the said client also plays a big role clarify “big role” since there various characteristics and trend associated with given individuals of a certain ethnic group or certain race. Consider clarifying subjective terms and or phrases which will offer the opportunity for the reader to have an exact impression of what you mean. Per WU, the purpose of this paper will be to discuss…..

Why the Patient Presented the System Described

The patient presented the symptoms mainly because of the acute graft rejection. Weight gain resulted from interstitial fluid retention, a decline in urine production, and declining renal function how is this determined and assessed? . Fever resulted from infection and immune suppression. Do you have a credible reference reflective of evidence-based medicine? I was looking for additional content reflective of the maladaptive physiological response.

Genes that’s that? may be Associated with the Development of Disease

The immune response to the graft partially depended on the gene disparity amid the host and the grafted organ. Xenograft, which occurs between different species members, exhibited the greatest disparity and elicited maximum immune response, experienced quick rejection. While Auto grafts autografts? are usually foreign tissues, hence they do not elicit rejection (Kwatra et al., 2017). On the other hand, Isograft, a graft that occurs amid a genetically identical person, did not undergo any form of rejection. The allograft, a graft that occurs amongst individuals for the same species, has different genes and represents the most common transplantation form. The measure to which the allograft undergoes rejection mainly depending on the extent of histocompatibility or the similarity between the donor and the recipient (Amini & Poorolajal, 2017). Consider including information specific to genes and post-transplant rejection associated with the case scenario.

The Process of Immunosuppression and the effect it has on body Systems

The rejection of the genetically disparate tissue is usually a result of histocompatibility antigens, products of the histocompatibility genes. These antigens are encrypted on about 40 loci, located in the main histocompatibility complex (MHC) near the complementary genes. The MHC genes are codominant expressed, meaning that all people usually express the genes on the cell surface from the alleles (Smedman et al., 2018).

The central cells involved in a draft rejection are the T cells, although other cells are also involved. The rejection reaction comprises both the effectors and sensitization stage. Consider a paragraph should be more than one sentence.

Upon transplantation, acute rejection usually manifests itself after the first six months. It is mediated by lymphocytes tissues of the recipients, activated against the donor antigen. The dendritic cells in the donor go into the circulation and acts as antigen-presenting cells. The humoral rejection is a subsequent dysfunction and allograft injury and occurs after post-transplantation, mainly in the first week. Proteinuria is linked with the specific donor antibody detected and controls swift glomerular filtration rate deterioration and past graft failure in patients who are the risk of developing de novo HLA antibodies. Is there a credible reference in support of this content?

Conclusion Consider a conclusion that his reflective of specific content related to the case scenario assigned.

From this case study, it is clear that adverse (what is meant by adverse knowledge?) knowledge on symptoms of altercations in cellular processes when diagnosing a patient is fundamental in the process of proper treatment of many diseases. Through proper (what is meant by proper?) understanding of various (what is meant by various?) parameters surrounding a patient, a healthcare officer (not sure what is meant by a healthcare officer?) can treat the patient patients’accordingly and alsoand advise them appropriately (define appropriately).

References

Amini, P., & Poorolajal, J. (2017). Prediction of kidney graft rejection using artificial neural network. Healthcare informatics research, 23(4), 277-284. Doi: 10.4258/hir.2017.23.4.277

Kwatra, V., Karanth, N. V., Priyadarshana, K., & Charakidis, M. (2017). Pembrolizumab for metastatic melanoma in a renal allograft recipient with subsequent graft rejection and treatment response failure: a case report. Journal of medical case reports, 11(1), 73. https://jmedicalcasereports.biomedcentral.com/articles/10.1186/s13256-017-1229-z

Smedman, T. M., Line, P. D., Guren, T. K., & Dueland, S. (2018). Graft rejection after immune checkpoint inhibitor therapy in solid organ transplant recipients. Acta Oncologica, 57(10), 1414-1418. Doi: 10.1080/0284186X.2018.1479069.