HEMATOLOGY WORKSHEETS

MLSC-382A INSTRUCTOR: BETH RAWSON

1 Rout Coag Wksht Updated: 8/9/2020

COAGULATION Worksheet STUDENT NAME: ___________________________ Please refer to your clinical site policies and procedures as needed to answer the following.

1. List the specimen requirements for coagulation testing. Anticoagulant/tube type

Fill volume

Sample type (be specific)

Stability time frame (PT, PTT only)

Specimen storage

2. List ALL reject criteria for coagulation testing (reasons a specimen is unacceptable for testing).

3. Explain the purpose for using the INR (International Normalized Ratio) instead of the PT (prothrombin time) when comparing results from one lab to another or evaluating anticoagulant therapy.

4. Where does the ISI come from (see INR formula below), and what is the reason for its inclusion in the calculation of the INR?

INR=(PT patient/PT normal)ISI

5. Name ALL coagulation factors the PT/INR (prothrombin time and INR) is sensitive to.

MLSC-382A INSTRUCTOR: BETH RAWSON

2 Rout Coag Wksht Updated: 8/9/2020

6. Explain why the PT/INR is used to monitor Coumadin/warfarin therapy. (HINT: What is the actual function of warfarin, and how does that relate to what is being measured by the PT?)

7. What is the therapeutic INR range for Coumadin/warfarin therapy?

8. Name ALL coagulation factors the PTT (partial thromboplastin time) test is sensitive to.

9. Explain why the PTT is used (most commonly) to monitor unfractionated heparin therapy. Specifically, how does heparin work as an anticoagulant, and why does the PTT show prolongation because of it?

10. What is the general therapeutic range for heparin therapy (PTT or Anti-Xa)?

11. Discuss the reason for the performance of the D-Dimer test, including associated disease states being evaluated.