Immunology test 3
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Biol434FiguresforChapter7.pptx
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Figure 7.1
Figure 7.4
Figure 7.3
| Uncommitted progenitor cell | Double-negative thymocyte committed to the T-cell lineage | ||
| C D 34 | Stem-cell surface marker | Positive | Negative |
| C D 44 | Adhesion | Positive | Negative |
| C D 2 | Adhesion and signaling | Negative | Positive |
| C D 5 | Adhesion and signaling | Negative | Positive |
| I L-7 receptor (C D 127) | Cytokine receptor | Negative | Positive |
| C D 1 A | M H C class-I-like molecule | Negative | Positive |
| C D 4 | Co-receptor | Negative | Negative |
| C D 8 | Co-receptor | Negative | Negative |
| T C R genes | Antigen receptor | Germline | Beginning to rearrange |
Figure 7.5
Figure 7.6
Helpful video on T cell development
Interaction of a double-positive T cell with a self-peptide: self-MHC complex during positive selection determines whether the T cell will become a CD4 or a CD8 T cell.
What happens if a self-reactive T cells are not negatively selected for apoptosis?
