Immunology test 3merlin123
|Uncommitted progenitor cell||Double-negative thymocyte committed to the T-cell lineage|
|C D 34||Stem-cell surface marker||Positive||Negative|
|C D 44||Adhesion||Positive||Negative|
|C D 2||Adhesion and signaling||Negative||Positive|
|C D 5||Adhesion and signaling||Negative||Positive|
|I L-7 receptor (C D 127)||Cytokine receptor||Negative||Positive|
|C D 1 A||M H C class-I-like molecule||Negative||Positive|
|C D 4||Co-receptor||Negative||Negative|
|C D 8||Co-receptor||Negative||Negative|
|T C R genes||Antigen receptor||Germline||Beginning to rearrange|
Helpful video on T cell development
Interaction of a double-positive T cell with a self-peptide: self-MHC complex during positive selection determines whether the T cell will become a CD4 or a CD8 T cell.
What happens if a self-reactive T cells are not negatively selected for apoptosis?