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Effects of electroconvulsive therapy in the systemic inflammatory balance of patients with severe mental disorder.

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Authors:

Bioque, Miquel1,2,3,4 (AUTHOR)

Mac‐Dowell, Karina S.3,5 (AUTHOR)

Meseguer, Ana1,3 (AUTHOR)

Macau, Elisabet6 (AUTHOR)

Valero, Ricard7,8 (AUTHOR)

Vieta, Eduard2,3,4,9 (AUTHOR)

Leza, Juan C.3,5 (AUTHOR) [email protected]

Bernardo, Miquel1,2,3,4 (AUTHOR) [email protected]

Source:

Psychiatry & Clinical Neurosciences. Oct2019, Vol. 73 Issue 10, p628-635. 8p. 1 Diagram, 2 Charts, 2 Graphs.

Document Type:

Article

Subject Terms:

*ELECTROCONVULSIVE therapy

*MENTAL illness

*NITRIC-oxide synthases

*MENTALLY ill

*INFLAMMATORY mediators

Author-Supplied Keywords:

biomarkers

ECT, electroconvulsive therapy, immune system, inflammation

Abstract:

Aim: There is a great interest in the role of the immune system and the inflammatory balance as key mechanisms involved in the pathophysiology of severe mental disorders. Previous studies have indicated that electroconvulsive therapy (ECT) produces changes in certain inflammatory mediators or in the immune system response. This study aimed to explore the effects of ECT on the nuclear transcription factor κB (NFκB) pathway, a main regulatory pathway of the inflammatory/immune response. Methods: Thirty subjects with a severe mental disorder receiving treatment with ECT in our center were included. Thirteen systemic biomarkers related to the NFκB pathway were analyzed right before and 2   h after a sing le ECT session. Results: An ECT session significantly decreased the expression of NFκB (P =   0.035) and of the inducible nitric oxide synthase (P =   0.012), and the plasma levels of nitrites (P =   0.027), prostaglandin E2 (P =   0.049), and 15‐deoxy‐PGJ2 (P <   0.001). Decrease in plasmatic levels of nitrites was greater in females than in males (P =   0.021). A positive correlation between the ECT stimulus load and changes in the expression of NFkB was found (P =   0.036). Thiobarbituric acid reactive substance levels were decreased in treatment responders and increased in non‐responders (P =   0.047). Conclusion: Our study shows the effects that a single session of ECT produces on a canonical regulatory pathway of the inflammatory/innate immune system and the inflammatory balance. These biomarkers could be useful as treatment response targets and could help to clarify the biological basis of ECT action. These findings warrant greater attention in future investigations and in the translational significance of these data. [ABSTRACT FROM AUTHOR]

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Author Affiliations:

1Barcelona Cl ínic Schizophrenia Unit, Neuroscience Institute, Hospital Clínic de Barcelona, Barcelona Spain

2Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona Spain

3Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM), Madrid Spain

4Department of Medicine, University of Barcelona, Barcelona Spain

5Department of Pharmacology & Toxicology, Faculty of Medicine, Universidad Complutense de Madrid, Instituto de Investigación I+12 y IUIN, Madrid Spain

6Psychiatry Department, Neuroscience Institute, Hospital Clínic de Barcelona, Barcelona Spain

7Anesthesia Department, Hospital Clínic de Barcelona, Barcelona Spain

8University of Barcelona, Barcelona Spain

9Barcelona Bipolar Disorder Program, Psychiatry Department, Neuroscience Institute, Hospital Clínic de Barcelona, Barcelona Spain

Full Text Word Count:

6282

ISSN:

1323-1316

DOI:

10.1111/pcn.12906

Accession Number:

138990292

Database:

Academic Search Complete

Publisher Logo:

Wiley-Blackwell